Hamster Tissue Custom Made NB-2
- Known as:
- Hamster Tissue Custom NB-2
- Catalog number:
- an-cus-2
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Zyagen
- Gene target:
- Hamster Tissue Custom Made NB-2
Related genes to: Hamster Tissue Custom Made NB-2
- Gene:
- CABP4 NIH gene
- Name:
- calcium binding protein 4
- Previous symbol:
- -
- Synonyms:
- CSNB2B
- Chromosome:
- 11q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2000-08-31
- Date modifiied:
- 2015-08-26
- Gene:
- CACNA1F NIH gene
- Name:
- calcium voltage-gated channel subunit alpha1 F
- Previous symbol:
- CSNB2, AIED
- Synonyms:
- Cav1.4, JM8, JMC8, CSNBX2, CORDX3, CSNB2A, OA2
- Chromosome:
- Xp11.23
- Locus Type:
- gene with protein product
- Date approved:
- 1997-04-21
- Date modifiied:
- 2016-02-04
- Gene:
- CLDN14 NIH gene
- Name:
- claudin 14
- Previous symbol:
- DFNB29
- Synonyms:
- -
- Chromosome:
- 21q22.13
- Locus Type:
- gene with protein product
- Date approved:
- 1999-11-26
- Date modifiied:
- 2016-10-05
- Gene:
- EEF1AKNMT NIH gene
- Name:
- eEF1A lysine and N-terminal methyltransferase
- Previous symbol:
- KIAA0859, DFNB26, METTL13
- Synonyms:
- CGI-01
- Chromosome:
- 1q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-11-10
- Date modifiied:
- 2018-09-05
- Gene:
- GRXCR1 NIH gene
- Name:
- glutaredoxin and cysteine rich domain containing 1
- Previous symbol:
- DFNB25
- Synonyms:
- PPP1R88
- Chromosome:
- 4p13
- Locus Type:
- gene with protein product
- Date approved:
- 2008-07-04
- Date modifiied:
- 2016-10-05
Related products to: Hamster Tissue Custom Made NB-2
Related articles to: Hamster Tissue Custom Made NB-2
- Early-onset asthma (EOA) significantly increases the risk of chronic obstructive pulmonary disease (COPD), yet the causal mechanisms and molecular mediators underlying this progression remain poorly understood. Multi-omics integration provides a powerful framework for prioritizing potential mediating proteins and disease-specific therapeutic candidates. - Source: PubMed
Jiang YuhanGuo JuWang YifanGuo RunWei YongjianLi TianchunWang XuelinXia RuiwenLi WanyiZou YingxueYang Hongxi - Obesity results from excessive fat accumulation driven by both genetic and environmental influences. While genome-wide association studies have found over 1,000 obesity-related variants, most research has centered on individuals of European descent. This study conducted a candidate gene association meta-analysis in 3,866 unrelated Mexican participants, examining 356 genes linked to obesity, abdominal obesity, body mass index, and waist circumference. The analysis replicated 56 known single-nucleotide variant associations and identified previously unreported association signals in genes such as , , , , and . Functional annotation revealed that variants, both within and outside mobile genetic elements, act as expression quantitative trait loci for 116 genes, especially in nervous, digestive, and endocrine tissues. These findings confirm established loci's relevance in Mexicans and highlight potentially population-specific candidate variants, emphasizing the importance of including diverse and underrepresented populations in genetic research on obesity. - Source: PubMed
Publication date: 2026/03/16
Huerta-Ávila Eira ElianaMartínez-Hernández AngélicaBarajas-Olmos FranciscoLópez-Escobar Tomas AlejandroRamirez-Martínez DiegoContreras-Cubas CeciliaGonzález-Villalpando María ElenaVillafan-Bernal José RafaelCenteno-Cruz FedericoQuiroz-Pineda José AntonioGonzález-Villalpando ClicerioGarcía-Ortiz HumbertoOrozco Lorena - Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, and cervical lymph node metastasis significantly impacts patient prognosis. This study aimed to develop interpretable artificial intelligence models based on transcriptomics to predict PTC occurrence and cervical lymph node metastasis, while exploring the heterogeneity of risk factors across different regions. We obtained 419 samples from the GEO database, originating from Asia, Europe, and America, comprising 158 normal samples, 203 PTC samples, and 58 metastatic samples. After comparing multiple machine learning algorithms, deep neural networks (DNN) demonstrated superior performance and were used to construct the PTC diagnostic and metastasis predictive models. The optimized PTC diagnostic model achieved an AUC of 0.987 with an accuracy of 0.945, while the PTC metastasis predictive model reached an AUC of 0.998 with an accuracy of 0.987. Model interpretation using SHapley Additive exPlanations (SHAP) and Kolmogorov-Arnold Networks (KAN) methods identified SYT1, REN, CNTN5, and ADAM12 as critical features for PTC diagnosis, whereas COL9A1, CYP4F3, and GAD1 were key predictors for PTC metastasis. Stratification analysis revealed regional differences in risk factors for PTC occurrence, while factors promoting PTC metastasis exhibited commonalities across different regions. Pathway enrichment analysis indicated that regulation of hormone levels and cell population proliferation were common pathways involved in both PTC occurrence and metastasis. Finally, we developed online predictive platforms based on the Streamlit framework to facilitate transparent model exploration and risk estimation. These tools are publicly accessible research-use prototypes intended for model demonstration and interpretability visualization. Because they require standardized gene-expression inputs and have not undergone prospective clinical validation, they should not be used as standalone tools for clinical diagnosis, risk stratification, or treatment decision-making. Overall, our findings identify candidate transcriptomic markers associated with PTC occurrence and lymph node metastasis and provide a basis for future translational evaluation. - Source: PubMed
Publication date: 2026/04/18
Zhang ZhigangLiu HongyuZhao ZhengTan GuoyuZhao YangLiu Xun - Vestibular dysfunction is strongly linked to cognitive impairment and dementia risk, yet its underlying mechanisms remain unclear, hindering treatment development. As a primary physical therapy intervention, aerobic exercise improves cognitive dysfunction. Thus, we investigated its potential to reverse cognitive deficits after vestibular dysfunction and explored the neurobiological mechanisms involved. - Source: PubMed
Zhou ZhanghongYu XixiTian EGuo ZhaoqiChen JingyuGuo JiaqiShi ShiyuXu WandiZhai NiQiao CaijuanZhang YuejinWang JunLu YishengZhang Sulin - Plasma proteins are potential biomarkers and drug targets that offer insights into the biological underpinnings of depression; yet, evidence linking them to depression is scarce. - Source: PubMed
Publication date: 2026/01/05
Abebe EndeshawMulugeta AnwarMadakkattel IqbalStacey DavidHyppönen Elina