Polyclonal ABHD8 antibody
- Known as:
- Polyclonal ABHD8 (anti-)
- Catalog number:
- stj91428
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- St Johns Labs
- Gene target:
- Polyclonal ABHD8 antibody
Related genes to: Polyclonal ABHD8 antibody
- Gene:
- ABHD8 NIH gene
- Name:
- abhydrolase domain containing 8
- Previous symbol:
- -
- Synonyms:
- FLJ11743, MGC14280, MGC2512
- Chromosome:
- 19p13.11
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-08
- Date modifiied:
- 2016-10-05
Related products to: Polyclonal ABHD8 antibody
Related articles to: Polyclonal ABHD8 antibody
- Bone is one of the distant metastases in patients with Breast Cancer (BC). However, the mechanism of BC bone metastasis is not fully understood. The aim of this study was to investigate the potential mechanisms linking bone metastasis-related genes and BC.The training set consisted of data from The Cancer Genome Atlas (TCGA)-BC dataset, which included 1,104 breast cancer samples (comprising 50 with bone metastasis and 1,052 without) and 114 adjacent normal samples. Differentially expressed genes (DEGs1) between breast cancer and normal tissues, as well as DEGs2 between breast cancer bone metastatic and non-bone metastatic tissues, were identified. Weighted gene co-expression network analysis (WGCNA) was then applied to screen breast cancer-related module genes. The intersection of these three sets was taken to obtain candidate genes. Diagnostic genes were identified via univariate Cox regression and Least Absolute Shrinkage and Selection Operator (LASSO) analysis to construct a risk model, which was subsequently validated using the Gene Expression Omnibus (GEO) dataset GSE20685 (327 samples, validation set). Furthermore, immune infiltration analysis, mRNA-miRNA-lncRNA regulatory network construction, and drug sensitivity analysis were performed in the training set. Finally, quantitative reverse transcription polymerase chain reaction (qRT-PCR) was conducted on clinical samples for validation.There were 756 DEGs between BC and control samples. A sum of 6 BC-related modules were acquired by WGCNA. After screening, 997 bone metastasis-associated genes and 73 candidate genes were acquired. A total of 6 diagnostic genes, namely ABHD8, ESRRA, DHPS, ISOC2, MRPL34 and OGFR, were obtained to construct the risk model. Results of the immune microenvironment analysis revealed that the high-risk group exhibited lower levels of certain immune cells, such as T cells and CD8+ T cells. Based on the public database,ESRRA was regulated by various miRNAs, such as hsa-miR-185-3p, hsa-miR-2115-5p. Based on the results of molecular docking experiments, a sum of 67 drugs had significant differences in IC50 between two risk subgroups. Transcriptomic data from TCGA indicated that all six diagnostic genes were significantly upregulated in the BC group (p < 0.05). However, qRT-PCR validation showed that ESRRA and OGFR were significantly downregulated in the BC group (p < 0.05), while the expression trends of the remaining four genes were consistent with the transcriptomic data.We explored the diagnostic genes (ABHD8, ESRRA, DHPS, ISOC2, MRPL34, and OGFR) of bone metastasis in BC, providing a reference for disease-related study. - Source: PubMed
Publication date: 2026/04/18
Tang JingLiu QiangTao ZhengyongNiu NingkuiZhan WenhuaShi JiandangYang Zongqiang - Colorectal cancer (CRC) is a highly aggressive gastrointestinal malignancy with significant global health consequences. While mitochondrial lipid metabolism genes are known to influence CRC progression, their prognostic relevance remains inadequately explored. - Source: PubMed
Publication date: 2025/11/10
Wang HouZhang KaiWang YueqiuChen MengyunZhang Mingchen - The NLRP3 inflammasome is a multiprotein complex that plays a vital role in the innate immune system in response to microbial infections and endogenous danger signals. Aberrant activation of the NLRP3 inflammasome is implicated in a spectrum of inflammatory and autoimmune diseases, emphasizing the necessity for precise regulation of the NLRP3 inflammasome to maintain immune homeostasis. The protein level of NLRP3 is a limiting step for inflammasome activation, which must be tightly controlled to avoid detrimental consequences. Here, we demonstrate that ABHD8, a member of the α/β-hydrolase domain-containing (ABHD) family, interacts with NLRP3 and promotes its degradation through the chaperone-mediated autophagy (CMA) pathway. ABHD8 acts as a scaffold to recruit palmitoyltransferase ZDHHC12 to NLRP3 for its palmitoylation as well as subsequent CMA-mediated degradation. Notably, deficiency results in the stabilization of NLRP3 protein and promotes NLRP3 inflammasome activation. We further confirm that ABHD8 overexpression ameliorates LPS- or alum-triggered NLRP3 inflammasome activation . Interestingly, the nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) impairs the ABHD8-NLRP3 association, resulting in an elevation in NLRP3 protein level and excessive inflammasome activation. These findings demonstrate that ABHD8 May represent a potential therapeutic target in conditions associated with NLRP3 inflammasome dysregulation. 3-MA: 3-methyladenine; ABHD: α/β-hydrolase domain-containing; BMDMs: Bone marrow-derived macrophages; CFZ: carfilzomib; CHX: cycloheximide; CMA: chaperone-mediated autophagy; CQ: chloroquine; DAMPs: danger/damage-associated molecular patterns; HSPA8/HSC70: heat shock protein family A (Hsp70) member 8; LAMP2A: lysosomal associated membrane protein 2A; NHCl: ammonium chloride; NLRP3: NLR family pyrin domain containing 3; PAMPs: pathogen-associated molecular patterns; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2. - Source: PubMed
Publication date: 2024/09/03
Yang ShuaiLi MengqiuLian GuangyuWu YaoxingCui JunWang Liqiu - Secondary progressive multiple sclerosis (SPMS) is the second most common presentation of multiple sclerosis (MS) and is characterized by a gradually deteriorating disease with or without relapses. Approximately 80% of patients with relapsing-remitting MS (RRMS) develop SPMS within 20 years. Epidemiological investigations have revealed an average 7-year life expectancy decrease (more severe in progressive subtypes) in patients with MS. Studies have focused on the neurodegenerative pathogenesis of SPMS; and epigenetic changes have been associated with disease progression in neurodegenerative disorders. However, the evidence for the association between epigenetic changes and SPMS is scarce. Thus, in this study we aimed to identify the key epigenetic genes in SPMS. - Source: PubMed
Publication date: 2022/01/07
Ye FeiDai YuanyuanWang TianzhuLiang JieWu XiaoxinLan KaiSheng Wenli - Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. To identify novel and pleotropic SqCC risk variants, we performed a meta-analysis of GWAS data on lung SqCC (LuSqCC), oro/pharyngeal SqCC (OSqCC), laryngeal SqCC (LaSqCC) and esophageal SqCC (ESqCC) cancers, totaling 13,887 cases and 61,961 controls of European ancestry. We identified one novel genome-wide significant (Pmeta<5x10-8) aerodigestive SqCC susceptibility loci in the 2q33.1 region (rs56321285, TMEM273). Additionally, three previously unknown loci reached suggestive significance (Pmeta<5x10-7): 1q32.1 (rs12133735, near MDM4), 5q31.2 (rs13181561, TMEM173) and 19p13.11 (rs61494113, ABHD8). Multiple previously identified loci for aerodigestive SqCC also showed evidence of pleiotropy in at least another SqCC site, these include: 4q23 (ADH1B), 6p21.33 (STK19), 6p21.32 (HLA-DQB1), 9p21.33 (CDKN2B-AS1) and 13q13.1(BRCA2). Gene-based association and gene set enrichment identified a set of 48 SqCC-related genes rel to DNA damage and epigenetic regulation pathways. Our study highlights the importance of cross-cancer analyses to identify pleiotropic risk loci of histology-related cancers arising at distinct anatomical sites. - Source: PubMed
Publication date: 2021/03/05
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