NME4 Pre-design Chimera RNAi
- Known as:
- NME4 Pre-design Chimera RNAi
- Catalog number:
- H00004833-R03
- Product Quantity:
- 10 nmol
- Category:
- -
- Supplier:
- Abno
- Gene target:
- NME4 Pre-design Chimera RNAi
Related genes to: NME4 Pre-design Chimera RNAi
- Gene:
- NME4 NIH gene
- Name:
- NME/NM23 nucleoside diphosphate kinase 4
- Previous symbol:
- -
- Synonyms:
- nm23-H4, NM23H4, NDPKD
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-12-19
- Date modifiied:
- 2016-07-15
Related products to: NME4 Pre-design Chimera RNAi
Related articles to: NME4 Pre-design Chimera RNAi
- Mitochondrial dysfunction is increasingly recognised as a key factor in the development and progression of atrial fibrillation(AF). - Source: PubMed
Publication date: 2026/07/02
Miao QingXue WeiqiLu XinkaiLian FeihongJin Zheng - Vitrification is a vital tool for the long-term preservation of animal genetic resources, yet cryoinjury-manifesting as oxidative stress, structural damage, and metabolic disorders-severely compromises its efficacy. Here, we investigated the protective effects of melatonin (MT) supplementation on the cryotolerance of mouse morulae. First, mouse morulae were assigned to four groups treated with vitrification and thawing media containing MT (0, 10, 10, and 10 M) to determine optimal MT concentration. Subsequently, embryos treated with the optimal MT concentration were evaluated for developmental competence, oxidative stress, apoptosis, and mitochondrial function. Furthermore, transcriptome sequencing was performed to elucidate MT-regulated molecular pathways. The results demonstrated that MT supplementation at 10 M significantly enhanced developmental competence, as evidenced by increased blastocyst rate, hatched blastocyst rate, total cell number and the inner cell mass (ICM)-to-total cell ratio compared to the MT-free group ( < 0.05). Consequently, embryo transfer outcomes showed higher live births and weaned pups in the 10 M MT group versus those in controls ( < 0.05), achieving levels comparable to fresh embryos ( > 0.05). Mechanistically, MT reversed cryoinjury-induced mitochondrial dysfunction by elevating membrane potential(MMP) and Adenosine Triphosphate(ATP) production while reducing Reactive Oxygen Species (ROS) accumulation ( < 0.05). Transcriptomic analysis further revealed that vitrification perturbed metabolic pathways, including amino acid/fatty acid degradation and glucose/pyruvate metabolism. MT downregulated cryoinjury-induced overexpression of and , inhibiting excessive NF-κB activation and alleviating metabolic dysfunction. Additionally, MT restored expression of nucleotide synthesis genes (, , , , , ) critical for cell proliferation, and reversed downregulation of mitochondrial genes and , confirming restoration of mitochondrial homeostasis. In conclusion, melatonin alleviates vitrification-induced cryoinjury by restoring mitochondrial function, which rescues nucleotide synthesis and partially reverses associated metabolic dysfunction. These findings advance MT-mediated cryoprotection and underscore its translational value for embryo cryopreservation in animal genetic resource conservation. - Source: PubMed
Publication date: 2026/05/26
Ji PengyunMa WenkuiZhao MengmengYan LaiqingLiu YunjieYin DepengChen QianruChen BodaWu HaoGao ShuaiWang BingyuanZhang LuLiu Guoshi - Minimising methane (CH) emissions from livestock production is a global priority, and feed modifications, such as supplementing diets with microalgae, have previously been shown to help reducing enteric CH production. This study explored blood-derived host gene expression profiles from twenty lambs supplemented with increasing levels of microalgae oil to investigate their transcriptional responses associated with varying microalgae oil levels while also exploring the host systemic responses towards varied CH productions. - Source: PubMed
Publication date: 2026/06/23
Chacko Kaitholil Steffimol RoseMooney Mark HAubry AurélieCristobal-Carballo OmarHillis RichardRazban VahidYan TianhaiRezwan Faisal IMorrison StevenHuws SharonShirali Masoud - Gastric cancer (GC) exhibits marked epidemiological differences between European (EUR) and East Asian (EAS) populations, with significantly higher incidence rates in EAS. Circulating proteins represent promising drug targets; however, most proteomic studies have focused primarily on EUR ancestry, leaving EAS-specific targets largely underexplored. This study aims to identify ancestry-specific plasma protein targets for GC using Mendelian randomization (MR). - Source: PubMed
Publication date: 2026/05/01
Zhi PengCui YanXue GuanghuiQiao LingyuGeng JieChang ZhengyaoXu YinmeiYan JuanjuanWang YingliZhao Chenghui - The development of circularly polarized luminescence (CPL) emitters with a luminescence dissymmetry factor (|g|) approaching the theoretical limit of 2 remains a central challenge in chiral photonics. Herein, considerable g values (1.48-1.65) were achieved in helicates (NMe)[Eu(R/S-)] (ΔΔ/ΛΛ--) with different structural rigidity, as well as in crown ether-modified (NMe)[Eu(R/S-)] (ΔΔ/ΛΛ-) that exhibits adjustable coordination geometry symmetry. Notably, encapsulating bulkier [NEt] instead of a [NMe] counterion within the inner cavity of ΔΔ/ΛΛ- further elevates |g| to an unprecedented 1.71, the highest value for any chiral molecular emitter. While the NMe-ΔΔ/ΛΛ- achieves an ultrahigh CPL brightness (B = 3625 M cm), resulting from its large g value (1.63) and high quantum yield (Φ = 32%). Structural and spectroscopic analyses demonstrate that the high CPL activity originates from a conformationally rigidified square antiprismatic (SAP) geometry around the Eu(III) center. This structure and property relationship is vividly demonstrated by the crown-ether-functionalized ΔΔ-, where gradual binding of Cs ions triggers a pronounced g fluctuation (1.48 → 0.62 → 1.41) through a perturbation and subsequent restoration of the SAP environment. Furthermore, the multicrown-ether binding sites in ΔΔ- enable cooperative guest binding, facilitating the first naked-eye CPL recognition of the antispasmodic drug tizanidine. This work establishes rigidifying SAP configuration as a general design principle for maximizing the CPL activity of lanthanide complexes and opening avenues for advanced CPL applications. - Source: PubMed
Publication date: 2026/04/15
Huang WenruYao ZhiweiYin SenGao TingCrassous JeanneZhou YanyanLi Hongfeng