polyclonal AMBP | Bikunin
- Known as:
- pab AMBP | Bikunin
- Catalog number:
- as04040
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Agrisera
- Gene target:
- polyclonal AMBP | Bikunin
Related genes to: polyclonal AMBP | Bikunin
- Gene:
- AMBP NIH gene
- Name:
- alpha-1-microglobulin/bikunin precursor
- Previous symbol:
- ITI, ITIL
- Synonyms:
- UTI, HCP, EDC1, HI30, IATIL, ITILC
- Chromosome:
- 9q32
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
Related products to: polyclonal AMBP | Bikunin
Related articles to: polyclonal AMBP | Bikunin
- Hemodialysis (HD) is one of the major treatment modalities for patients with kidney failure; moreover, there are many alternatives, such as expanded HD (HDx) and on-line hemodiafiltration (HDF). This chapter begins with a historical overview of these treatment modalities and discusses the current mainstream treatments in Europe, North America, and Japan. The "protein-losing" dialysis membrane was first realized in Japan in the early 1980s, and treatment using these membranes has evolved into HDx and/or on-line HDF with an albumin leakage range of 3-6 g, which corresponds to a 30-40% reduction rate in α-microglobulin levels over the course of a single dialysis session that reduces or eliminates many clinical symptoms. Whether albumin-leaking membranes are "friends or foes" depends on the patient's general conditions; however, based on our more than 40 years of clinical experience in Japan, they are generally considered "friends." - Source: PubMed
Publication date: 2026/09/10
Yamashita Akihiro C - Acute liver failure (ALF) is a serious clinical disease. Immune infiltration and oxidative stress (OS) play an important role in ALF, but the combination of oxidative stress and immune infiltration in ALF has not been explored. - Source: PubMed
Publication date: 2026/09/09
Dai LuTan JungangZhou ZhiminChen ChengcongHu GuoxinGuo Ling - Urine tubular biomarkers have previously been associated with chronic kidney disease (CKD) progression independently of estimated glomerular filtration rate (eGFR) and albuminuria. We evaluated whether nine urine tubular biomarkers could improve prediction of kidney failure beyond serum creatinine and urine albumin-to-creatinine ratio among adults with CKD. - Source: PubMed
Publication date: 2026/09/03
Malijan Greco BHerrington William GJudge Parminder KSardell Rebecca JChapman DanielHill MichaelMoffat StewartZhu DoreenCheung Alfred KSteubl DominikLandray Martin JWanner ChristophBaigent ColinHaynes RichardIx Joachim HStaplin NatalieShlipak Michael G - Sickle cell nephropathy remains a major contributor to morbidity in adults with Sickle Cell Disease (SCD), yet proximal tubular injury remains insufficiently characterized, particularly in African settings. Alpha-1 Microglobulin (A1M), a low-molecular-weight protein, may serve as a sensitive biomarker of proximal tubular dysfunction. - Source: PubMed
Publication date: 2026/09/02
Engole Yannick MompangoNlandu Yannick MayambaNkodila Aliocha NatuhoyilaMakanzu BradyMvita YannickNgoy Grace MomaMansoni Blondy MveteMvibudulu RaggueLukoki BeudinNyemba Sarah MukayiKinja Louange ZihirweSumaili Ernest Kiswaya - The traditional Chinese medicinal herb Allium macrostemon Bunge (AMB) possessed both nutritional value for consumption and health benefits. Although it was extensively used in many areas, studies on its polysaccharide fractions were still limited at present. In this study, ultrasonic-assisted extraction was adopted to prepare Allium macrostemon Bunge polysaccharides (AMBP), and three strategies including Box-Behnken design (BBD), genetic algorithm optimized back propagation neural network (GA-BP), and gradient boosting decision tree (GBDT) were separately employed to optimize the extraction parameters. Experimental results demonstrated that the GA-BP model exhibited superior data fitting and prediction performance with remarkably higher prediction accuracy compared with the BBD and GBDT models. The coefficient of determination (R) reached 0.9829, with a RMSE of 0.3086 and a MAE of 0.1717. The GA-BP model yielded the following predicted optimal conditions: temperature 50 °C, extraction time 33 min, and liquid-to-solid ratio 1:30 g/mL. The neutral polysaccharide AMBP-1 was isolated and purified by column chromatography, and its structural characterization was subsequently performed. The results indicated that AMBP-1 was a homogeneous polysaccharide with a relative molecular mass of 5.56 kDa, exhibiting an irregular sheet-like morphology, and its backbone structure was → 4)-β-D-Glcp-(1 → 6)-β-D-Galp-(1 → . Preliminary in vitro cellular assays and in vivo immunosuppressive mouse models demonstrated that AMBP-1 possessed immunomodulatory activity, and multi-omics analysis revealed potential correlations between its effects and alterations in gut microbiota, serum metabolites, and immune-related transcriptional profiles. In conclusion, this study established an efficient ultrasonic-assisted extraction process optimized by the GA-BP model, providing a reliable technical foundation for the preparation of AMBP, and laid the groundwork for the application of AMBP-1 in functional foods and nutraceuticals. - Source: PubMed
Publication date: 2026/08/24
Yao JingjingMa AntingChen YusangZhang YujiaTang XiuyuShi SenlinHan XiZhang Ting