polyclonal SCGB2A2 | Mammaglobin-A
- Known as:
- pab SCGB2A2 | Mammaglobin-A
- Catalog number:
- as03029
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Agrisera
- Gene target:
- polyclonal SCGB2A2 | Mammaglobin-
Related genes to: polyclonal SCGB2A2 | Mammaglobin-A
- Gene:
- SCGB2A2 NIH gene
- Name:
- secretoglobin family 2A member 2
- Previous symbol:
- MGB1
- Synonyms:
- UGB2, MGC71974
- Chromosome:
- 11q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-07-22
- Date modifiied:
- 2016-10-05
Related products to: polyclonal SCGB2A2 | Mammaglobin-A
Related articles to: polyclonal SCGB2A2 | Mammaglobin-A
- Breast cancer is the most common cancer in women worldwide, and early detection remains a significant challenge. Recent studies have identified increased expression of Mammaglobin A (Q13296, Gene: ) mRNA in breast cancer, suggesting its potential as a disease marker, although its function is not fully understood. To elucidate Mammaglobin's role, this study sought to identify co-expressed miRNAs and analyze the biological pathways they regulate. - Source: PubMed
Publication date: 2026/09/01
Abella-Duque Juan FelipeLópez-Kleine LilianaParra-Medina RafaelRamírez-Clavijo SandraPayán-Gómez César - Breast cancer represents a major public health problem worldwide. Despite radical surgery for localized disease, a substantial proportion of patients experience disease recurrence. The aim of this study was to evaluate the expression of the mammaglobin and CK19 genes in sentinel lymph node biopsies from patients with early breast cancer. This descriptive study included 301 sentinel lymph node biopsies from patients with stage I-II breast cancer treated at the San Carlos Clinical Hospital in Madrid, Spain. Metastases were identified using conventional histopathology (H&E), immunohistochemistry (IHC), and molecular detection of mammaglobin and CK19 using PCR-based methods. Associations between variables were assessed using Fisher's exact test with a 95% confidence level. Statistical analyses were performed using STATA 12.0. The predictive value for metastatic involvement was 12.29% for CK19 and 16.61% for mammaglobin, increasing to 19.27% when conventional staining was combined with immunohistochemistry. The overall sensitivity was 68.9%, and the specificity was 93.42%. Mammaglobin showed slightly better diagnostic performance than CK19, and the combined molecular detection of both genes improved diagnostic accuracy when compared with individual markers. Intraoperative molecular evaluation of sentinel lymph nodes using mammaglobin and CK19 is comparable to conventional histopathological assessment combined with immunohistochemistry. The combined RT-PCR detection of both genes improves diagnostic performance and represents a clinically useful complementary tool for the detection of metastatic involvement in early breast cancer. - Source: PubMed
Publication date: 2026/05/16
Zambrano Diana CarolinaMatta Andrés JenuerMaestro de Las Casas María LuisaSua Luz Fernanda - Moll glands, found in the margin of the eyelid next to the base of the eyelashes, are likely to play an important role in maintaining the tear film and therefore in securing adequate visual function. However, information about their secretion and its regulation is extremely scarce. Here, we subjected spatial transcriptome data of the human eyelid to bioinformatics workflows incorporating machine learning to shed light on the Moll-specific transcriptional program. We identified Moll-specific genes such as HPD, CYP4Z1, PIP, GLYATL2, or SCGB2A2, which delineate a transcriptional core, i.e. not shared with other eyelid elements. Gene ontology enrichment analyses further depicted the biological functions of the Moll gland transcriptional programs, which include tyrosine metabolism and biosynthesis, extracellular exosome, small molecule metabolism, and erythrose 4-phosphate/phosphoenolpyruvate-family amino acid metabolism. Expression of GLYATL2 and HPD, identified as a specific and sensitive transcripts in the Moll gland transcriptome, was confirmed by immunofluorescence in the eyelid of four different patients, thus supporting the validity of our approach. Collectively, these results indicate that Moll-associated gene sets exhibit distinct but complementary functional programs, reflecting the gland's specialized metabolic capacity and secretory function within the eyelid tissue microenvironment. Our study provides the first in-depth analysis of the human Moll gland transcriptional landscape and identifies novel targets for regulating Moll gland homeostasis in health and disease. - Source: PubMed
Konecny TomasBinder HansHampel UlrikeHansmann FlorianPfannkuche HelgaSchneider Marlon R - Lentinan, a β-glucan extracted from Lentinus edodes, has been reported to exert potent antitumor activity. However, its underlying mechanism in breast cancer (BRCA) remains insufficiently elucidated. In this study, we investigated the direct antitumor effects of the water-extracted Lentinus edodes polysaccharide (WLNT) on human BRCA both in vitro and in vivo. Upon intravenous administration, WLNT reached the tumor site, peaked at 30 min and remained detectable for up to 2 h. Treatment with 1 mg/mL WLNT markedly suppressed tumor growth. Specifically, WLNT inhibits BRCA growth by downregulating the expression of CD133, a key marker of breast cancer stem cells. In addition, proteomic screening revealed that WLNT significantly downregulated the expression of SCGB2A2 (mammaglobin-A), whose levels are associated with the CD133 concentration in cells. Notably, SCGB2A2 was identified to promote BRCA cell proliferation, migration and xenograft tumor growth. We identified a novel anti-BRCA mechanism of WLNT in downregulating SCGB2A2 expression. Further investigation revealed that CD133 directly interacted with SCGB2A2 and accelerated its lysosomal degradation in cells under physiological conditions. WLNT competitively binds to CD133, inhibiting its interaction with SCGB2A2. In summary, our study demonstrates the critical role of the tumor-promoting effectors CD133 and SCGB2A2 in the anti-BRCA activity of WLNT, providing a new perspective for the study of the antitumor mechanism of lentinan. - Source: PubMed
Publication date: 2026/03/10
Wang JingyiCheng HuazhengMu XuLiu YanHuang LeiWu NireZhan YuxueZhang YuWang JinglinWang Kaiping - The Small-Tailed Han (STH) sheep milk has significantly higher fat and protein than DairyMeade (DM) sheep milk. Further study found that the expression of whey protein secretoglobin family 2 A member 2 (SCGB2A2) in STH sheep milk was significantly higher than in DM sheep milk. Thus we surmise that the SCGB2A2 may be involved in the regulation of the mammary biological function. Here, the expression of SCGB2A2 at different lactation periods was detected first. Then the cell proliferation and milk component synthesis effects on ovine mammary epithelial cells (OMECs) were analyzed. And the CUT&Tag analysis was used to identify SCGB2A2 target binding sites at the genome. The transcriptome of SCGB2A2 overexpression and knockdown OMECs was analyzed. Two co-analyses were conducted to further screen out SCGB2A2 potential target genes. Finally, the potential interacting protein was verified by CO-IP and UHLP-MS analysis. Results showed that the SCGB2A2 was expressed highest at the colostrum stage and lowest at the dry milk stage. Immunohistochemical analysis showed that it was mainly expressed in mammary epithelial cells. CCK8 and cell cycle analysis showed that SCGB2A2 promotes the OMECs proliferation. Milk components synthesis detection found that the SCGB2A2 was positively correlated with the CSN2, lactose, and triglyceride (TG). CUT&Tag and transcriptome co-analyses found that 20 genes were consistently detected, including FBP2, IFIT3 and so on. CO-IP analysis demonstrated that mTOR interacted with SCGB2A2. Taken together, we demonstrated that SCGB2A2 plays a positive role in OMECs proliferation and biosynthesis of milk components. Some SCGB2A2 direct regulated genes are involved in the cell proliferation. The regulation of SCGB2A2 for milk components biosynthesis mainly interacts with mTOR. However, the specific regulatory mechanism is needed to further study. - Source: PubMed
Publication date: 2026/02/09
Ma SijiaBai HuiHan LidongZhu YijingXie AnpingFang RuilinHu XvhuiZhang LiguoBian ChaoSu Xiaohu