Mouse Adiponectin Receptor 1,ADIPOR1 ELISA Kit
- Known as:
- Mouse Adiponectin Receptor 1,ADIPOR1 Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- dl-adipor1-mu
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Wuxi donglin
- Gene target:
- Mouse Adiponectin Receptor 1 ADIPOR1 ELISA Kit
Related genes to: Mouse Adiponectin Receptor 1,ADIPOR1 ELISA Kit
- Gene:
- ADIPOR1 NIH gene
- Name:
- adiponectin receptor 1
- Previous symbol:
- -
- Synonyms:
- PAQR1, ACDCR1
- Chromosome:
- 1q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-23
- Date modifiied:
- 2018-05-03
Related products to: Mouse Adiponectin Receptor 1,ADIPOR1 ELISA Kit
Related articles to: Mouse Adiponectin Receptor 1,ADIPOR1 ELISA Kit
- Adiponectin signaling is essential for hepatic glucose homeostasis, yet the molecular basis of adiponectin receptor responsiveness remains incompletely understood. Here, we identify the Nogo-B receptor (NgBR; NUS1) as a regulator of hepatic adiponectin sensitivity. Across human, cynomolgus monkey, and mouse datasets, hepatic NgBR expression is consistently reduced in obesity-associated diabetes, indicating a conserved metabolic signature. Hepatocyte-specific NgBR deletion abolishes the metabolic effects of the adiponectin agonist AdipoRon, resulting in impaired AMPK activation, persistent gluconeogenesis, and ceramide accumulation. Mechanistically, NgBR loss suppresses KAT7 expression and reduces histone acetylation at AdipoR1 and AdipoR2 promoters, thereby limiting receptor expression. Adeno-associated virus (AAV)-mediated restoration of hepatic NgBR reinstates KAT7-dependent chromatin activation, adiponectin receptor expression, and glucose homeostasis. These findings support a hepatocellular mechanism in which NgBR maintains adiponectin receptor competence and suggest a potential therapeutic strategy for restoring adiponectin responsiveness in metabolic disease. - Source: PubMed
Publication date: 2026/05/22
Mohiuddin Mohammad SarifTirumalasetty Munichandra BabuHu WenquanBarua RashuWahiduzzaman MdChoubey MayankSchwartz Gary JMiao Qing Robert - Sus scrofa has been domesticated under diverse environments and management systems, leading to broad variation in genetic architecture and physiological regulation. This diversity has been preserved in indigenous breeds maintained under traditional husbandry and further expanded through modern crossbreeding programs designed to combine the distinctive attributes of native and commercial lineages. To investigate how such lineage diversity is reflected at the structural genomic level, whole-genome sequencing data from 110 pigs representing 13 populations were analysed to characterize genome-wide copy number variation (CNV) patterns and identify regions showing differential CNV patterns among lineages. Comparative analysis revealed distinct CNV landscapes between indigenous and commercial groups, encompassing 282 significantly differentiated CNV regions (CNVRs). Selection signatures defined by V and Wilcoxon tests highlighted genes involved in lipid metabolism (FAR2, MGLL, FASN), suggesting that CNV differences may underlie the characteristic fat-deposition traits of native breeds. Within the same analytical framework, crossbred populations exhibited inheritance patterns consistent with parental lineage influence: native-like CNVRs harboured lipid-associated genes (ADIPOR1, MLXIPL, GPIHBP1), whereas commercial-like CNVRs contained loci related to muscle development and growth (CAPN1, PDGFA, EEF1A2, SH2B1). These results collectively provide genomic insight into how CNVs reflect the effects of historical adaptation and selective breeding in domestic pigs. The differentiated CNVRs identified here encompass genes involved in fat deposition and muscle biology, suggesting potential links to trait variation across lineages. This work offers a genomic foundation for future studies integrating CNV and functional traits, and highlights the value of structural variation in informing crossbreeding and breed-improvement strategies. - Source: PubMed
Kim BongsangSeo JeongwooKim HeebalKim Young-SinLee JonganCho Seoae - Obesity is a multifactorial metabolic disorder characterized by excessive adipose accumulation and dysregulated lipid and glucose homeostasis. Marine brown algae contain diverse bioactive compounds with potential metabolic benefits; however, the in vivo anti-obesity effects of remain insufficiently characterized. - Source: PubMed
Publication date: 2026/05/15
Bahtiar AntonWahyudi Dinda Puspita DewiWidiarti RianiSiriamornpun Sirithon - Periodontitis is a chronic inflammatory disease which is initiated by dysbiotic biofilms and maintained by a host who is permissive to inflammation resulting in continuous destruction of periodontal supporting structures. Periodontitis occurs frequently with obesity and type 2 diabetes mellitus and the broader cardiometabolic risk state leading to investigations into the common immunometabolic pathways that link these conditions. Adiponectin, an insulin sensitizing and anti-inflammatory adipokine which can also act as a vasculoprotective and bone-related factor, has been studied as a potential modulator of the relation between periodontal inflammation and systemic metabolic disturbance. This narrative review summarizes the biology of adiponectin and its receptors, human findings relating to both the local and circulating forms of adiponectin in periodontal health and disease, the mechanism in cell and animal models and translational implications and limitations. The literature was reviewed in a narrative manner with particular attention to study quality, compartment-specific biology and any conflicts in evidence and the difference between biological plausibility and clinical relevance. A tendency for a reduction in the circulating, saliva and gingival crevicular fluid levels of adiponectin in periodontitis in human studies, particularly those with co-existing obesity and type 2 diabetes mellitus, can be demonstrated but these finding are often disparate due to variable methods in case definitions, assay techniques, metabolic background of subjects and other confounders. Experimental findings may establish biological plausibility by linking adiponectin signalling with the mechanisms which affect inflammatory responses, endothelial function and matrix homeostasis, osteoclastogenesis and subsequent alveolar bone loss, although adiponectin signalling appears context-specific in its actions and this does not confirm clinical relevance. Evidence suggests adiponectin is a biologically significant, but context-dependent factor within the immunometabolic network which connects periodontal disease with the systemic condition, rather than a sole marker or clinically recognized target for therapeutic intervention. - Source: PubMed
Publication date: 2026/05/08
Mochol MartynaDura WłodzimierzLodigkeit MaikeAndrzejewski PiotrLipski MariuszMazurek-Mochol Małgorzata - Microbiota-derived metabolites are increasingly recognized as modulators of systemic immunity and cancer biology. This study investigates how a structurally distinct lipid from Akkermansia muciniphila influences immune transcriptional programs and their connection to breast cancer (BRCA)-associated pathways. - Source: PubMed
Chaudhary UmaA S AryaA Mythili