AGTR1 Pre-design Chimera RNAi
- Known as:
- AGTR1 Pre-design Chimera RNAi
- Catalog number:
- H00000185-R06
- Product Quantity:
- 10 nmol
- Category:
- -
- Supplier:
- Abno
- Gene target:
- AGTR1 Pre-design Chimera RNAi
Related genes to: AGTR1 Pre-design Chimera RNAi
- Gene:
- AGTR1 NIH gene
- Name:
- angiotensin II receptor type 1
- Previous symbol:
- AGTR1B
- Synonyms:
- AT1, AT2R1, AGTR1A, AT2R1A, HAT1R, AG2S, AT2R1B, AT1B
- Chromosome:
- 3q24
- Locus Type:
- gene with protein product
- Date approved:
- 1992-08-25
- Date modifiied:
- 2017-07-07
Related products to: AGTR1 Pre-design Chimera RNAi
Related articles to: AGTR1 Pre-design Chimera RNAi
- Hetian black chicken is an indigenous breed endemic to Xinjiang, China, known for its remarkable adaptability to harsh desert environments. Age at first egg (AFE) and egg number at 300 days of age (EN300) are important reproductive traits, yet their molecular genetic basis remains unclear. Here, we combined whole-genome resequencing (64 hens) and transcriptome sequencing (ovary and uterus from 13 hens) to identify candidate genes and SNPs associated with AFE and EN300. Using F, Pi, and XP-CLR methods, we identified 7 overlapping candidate genes for AFE (core genes: ATAD5/CRLF3 on chr18, AGTR1 on chr9) and 20 overlapping candidate genes for EN300 (core genes: NRXN3 on chr5, AHR2/NDUFA10 on chr7, and PRSS2/PRSS3/PDE3A on chr1). AFE-associated core genes were significantly enriched in Apelin, adrenergic, and calcium signaling pathways, with 8 core SNPs detected (2 novel). Transcriptomic validation confirmed ovary-specific high expression of CRLF3 and ATAD5 (P < 0.01). EN300-associated core genes were significantly enriched in neuroactive ligand-receptor interaction and Influenza A pathways, with 16 core SNPs detected (all known). NRXN3 showed stable differential expression across all tissue and group comparisons, whereas AHR2 and PRSS2 exhibited tissue-specific expression patterns. These results indicate that ATAD5/CRLF3 on chr18, AGTR1 on chr9 and their SNPs are potential markers for AFE, while NRXN3 on chr5, AHR2 on chr7, PRSS2 on chr1 and their SNPs are potential markers for EN300. This study provides a theoretical basis for marker‑assisted selection of reproductive traits in Hetian black chickens. - Source: PubMed
Publication date: 2026/09/24
Liu TianciLi FuguiWang ChengqianLiu MinTurxunjan NursatHou WenqiangLiu YuxuanQu LujiangWang Huie - Polyendocrine metabolic ovarian syndrome (PMOS) is characterized by hyperandrogenism, particularly excessive testosterone, as a core clinical feature and a key pathogenic metabolite, yet its molecular mechanisms remain incompletely understood. This study integrated multi-omics data from Gene Expression Omnibus (GEO) databases with network toxicology, weighted gene co-expression network analysis (WGCNA), and machine learning to identify testosterone-associated core genes in PMOS. Differential expression analysis and WGCNA yielded 42 candidate genes, from which five core genes, including GK5, CYP3A5, EGLN3, VCAM1, and AGTR1, were prioritized as top predictive features through ensemble modeling (RF + XGBoost). Molecular docking predicted favorable testosterone binding conformations. Regulatory network and drug enrichment analysis additionally predicted several upstream transcription factors, hub miRNAs, and potential repurposable drugs. These findings proposed a computational framework for a multi-target molecular landscape linking testosterone to PMOS. The identified genes, regulatory networks, and candidate drugs provided prioritized hypotheses for mechanistic exploration and future evaluation of potential diagnostic and therapeutic applications in hyperandrogenism-related PMOS. - Source: PubMed
Publication date: 2026/09/09
Li ChaoSu ZheLi YiqianLiu HuiliZheng MengyiZhou HanjingWei ChengZhou FengYang CuiyuTang ChenChen Bin - Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease. The hyperactivation of fibroblast-like synoviocytes (FLS) is a major contributor to synovial hyperplasia and cartilage destruction, and FLS pyroptosis plays a pivotal role in RA pathogenesis. This study aimed to investigate the mechanisms by which AGTR1 regulates FLS pyroptosis and inflammatory cytokine secretion in RA to identify potential therapeutic targets for RA. - Source: PubMed
Publication date: 2026/08/15
Wang JianBai Zongbiao - This study was aimed to develop a mathematical model for predicting the presence of pathological alleles of the angiotensin II receptor type 1 (AGTR1) (C1166C) and endothelial nitric oxide synthase (eNOS) (T786C) genes in patients with arterial hypertension using readily available clinical and demographic parameters without the need for laboratory genetic analysis. The study included 86 patients with arterial hypertension, 45 of whom had also clinical signs of ischemic heart disease and 30 healthy controls. Clinical and demographic data, including age, sex, body mass index (BMI), smoking and alcohol habits, and systolic and diastolic blood pressure, were collected. A predictive model of genetic polymorphism was constructed using a multivariate regression analysis in Statistica 10.0. Model quality was assessed via residual analysis (histogram, normal probability plot, scatter plot), ANOVA, and the Nagelkerke coefficient of determination (R²). Eight significant predictors of pathological gene variants were identified: age, sex, disease duration, BMI, smoking, alcohol consumption, systolic blood pressure, and diastolic blood pressure. The regression model explained 98.42% of the variance in gene polymorphism (R²=0.9842). Residuals were normally distributed and randomly scattered confirming the model adequacy. ANOVA analysis demonstrated high statistical significance (p<0.001) indicating that the model performed significantly better than predictions based on the mean values. The model allows inference of the probable presence of C alleles in AGTR1 and eNOS genes using simple clinical information. The proposed mathematical model demonstrates high predictive capability and statistical stability providing a cost-effective tool for preliminary genetic screening in patients with hypertension. It enables identification of individuals at risk for carrying pathological gene variants and supports the implementation of a personalized approach in clinical practice. Further validation on independent datasets is recommended. - Source: PubMed
Publication date: 2026/09/19
Pidruchna SvitlanaYarema NadiyaKuzmak IrynaProkopovych OlenaKotsiuba OksanaSverstuk AndriiBahrii-Zaiats OksanaLykhatskyi PetroMudra AllaPalytsya LylyaLetniak NataliyaOstrivka OksanaYaroshenko TetyanaVasylyshyn Nadija - [This corrects the article DOI: 10.1016/j.omton.2026.201253.]. - Source: PubMed
Publication date: 2026/09/10
Ikoma TatsukiAraki KeigoKitagawa MaiMakihara NatsunoNagata YutaroFujii KazukiOkuno YukikoYuta Okazaki Keisuke KamisakoNakanishi KentaroSanada YumeYoshida KiyoriNakahama KahoriTakeyasu YukiKatsushima UtaeYamanaka YutaIkeda SatoshiYoshioka HiroshigeShimizu ToshioKurata Takayasu