Protein,LYVE1
- Known as:
- Protein,LYVE1
- Catalog number:
- 38141
- Product Quantity:
- 0.25 mg
- Category:
- -
- Supplier:
- GenWay
- Gene target:
- Protein LYVE1
Related genes to: Protein,LYVE1
- Gene:
- LYVE1 NIH gene
- Name:
- lymphatic vessel endothelial hyaluronan receptor 1
- Previous symbol:
- XLKD1
- Synonyms:
- LYVE-1
- Chromosome:
- 11p15.4
- Locus Type:
- gene with protein product
- Date approved:
- 2001-03-21
- Date modifiied:
- 2015-07-22
Related products to: Protein,LYVE1
Related articles to: Protein,LYVE1
- Rheumatoid arthritis (RA) is a complex autoimmune joint disease characterized by persistent synovial inflammation and hyperplasia. The TNF-α/NF-κB signaling pathway is one of the most important inflammatory pathways involved in the onset and progression of RA. In addition, impaired lymphatic drainage plays a critical role in disease exacerbation. Iguratimod (IGU), a novel disease-modifying antirheumatic drug, has been shown to exert immunomodulatory effects. However, the precise mechanisms underlying its anti-inflammatory function remain unclear. Furthermore, whether IGU could restore lymphatic reflux function in inflammatory arthritis has yet to be determined. Therefore, the study aimed to elucidate the mechanisms underlying the therapeutic effects of IGU in RA. The therapeutic efficacy of IGU was evaluated in a collagen-induced arthritis (CIA) mouse model, with methotrexate used as a positive control. Histopathological analyses of footpad and ankle tissues were performed to asses of disease onset and progression. Levels of inflammatory cytokines (e.g., TNF-α, IFN-γ, IL-4, and IL-6) and IgG autoantibody (such as anti-CCP antibody) were determined using ELISA. Lymphangiogenic markers, including VEGF-C, VEGFR-3, and LYVE-1, were assessed in ankle joint tissues. The protein and mRNA expression levels of TNF-α and NF-κB in joint tissues were also evaluated. In addition, an in vitro tube formation assay was performed to examine the direct effects of IGU on lymphangiogenesis. IGU treatment significantly alleviated arthritis severity in CIA mice by reducing joint inflammation, minimizing tissue damage, and preserving bone integrity. Beyond its established anti-inflammatory properties, IGU could enhance lymphangiogenesis in inflamed joints. Mechanistically, IGU suppressed the TNF-α/NF-κB signaling pathway, thereby attenuating immune responses and inflammatory cytokine production. Furthermore, IGU directly promoted lymphatic vessel formation by upregulating LYVE-1, Prox-1, VEGF-C, and VEGFR-3 in lymphatic endothelial cells. The effect might contribute to the restoration of lymphatic drainage function. The study suggests that IGU exerts a dual therapeutic action by modulating inflammation and promoting lymphatic vessel formation, which might facilitate the restoration of lymphatic drainage and contribute to improved outcomes in RA. - Source: PubMed
Publication date: 2026/05/20
Du MinminXu XiaofenCui XiaohuiChen YilinZhao PengHu QingqingWang CaifengZhang JidaHao GuifengHu Changfeng - Papillary thyroid carcinoma (PTC) with metastatic potential presents a complex and poorly understood tumor microenvironment. Despite its clinical significance, the cellular and molecular mechanisms driving metastatic progression remain inadequately characterized, particularly the role of intercellular communication mediated by tumor-derived exosomes. - Source: PubMed
Publication date: 2026/05/08
Qiu WangwangYan TingHuang XinyuFan YoubenDi JianzhongYang Zhili - BackgroundOsteoarthritis (OA) of the knee is a degenerative disorder characterized by cartilage degradation, synovial inflammation, and structural remodeling. Synovial fluid (SF) biomarkers may improve diagnosis, staging, and patient stratification.MethodsFollowing PRISMA guidelines, a systematic search of PubMed and Scopus (2015-2025) was conducted. Human studies analyzing SF with proteomic techniques (LC-MS/MS, SWATH-MS, ELISA) were included. Extracted data were classified by OA stage, sample type, proteomic platform, and identified biomarkers. Functional enrichment was performed with ShinyGO, and protein-protein interaction (PPI) analysis with STRING (v12.0).ResultsSeven studies met the inclusion criteria. Reported biomarkers included Cathepsin G (CTSG), angiotensinogen (AGT), periostin (POSTN), haptoglobin (HP), complement components, and matrix-related proteins such as ADAMTS4 and LYVE-1, which are involved in extracellular matrix remodeling, inflammation, and joint tissue homeostasis. Functional annotation revealed enrichment in glycosaminoglycan binding, complement cascades, and redox pathways. PPI analysis identified central nodes including COL1A1, ACAN, COMP, and POSTN, together with matrix-degrading enzymes such as MMP1, MMP3, and MMP13, highlighting tightly connected extracellular matrix remodeling processes in OA.ConclusionThis review highlights reproducible SF biomarkers with diagnostic and prognostic potential in knee OA. Integrated proteomic and network analysis reinforces the multifactorial nature of OA and suggests key molecular targets. Translationally, a consistent biomarker signature could support early detection, more precise staging, and personalized management, enabling biomarker-guided diagnostics, targeted therapies, and the integration of precision medicine into OA care. - Source: PubMed
Publication date: 2026/05/13
Parrotta Elvira ImmacolataBenedetto Giorgia LuciaCuda GiovanniCovello RaffaeleLongo Umile GiuseppeCarnevale AriannaGalasso OlimpioGasparini GiorgioMercurio Michele - Fatty liver diseases are highly prevalent worldwide, driven by hepatocyte metabolic dysfunction and alcohol consumption. Both cell-autonomous and non-cell-autonomous mechanisms contribute to hepatic lipid accumulation. Here, we investigated the role of liver endothelial cell-hepatocyte communication in regulating lipid metabolism. - Source: PubMed
Publication date: 2026/05/11
Rao XiyunZhao QianqianChen JinbiaoZheng MinXing MingyueFeng YuChen JiayuanZhu ShichaoHan ZhimingMcCaughan Geoffrey WZheng Xiangjian - Kaposiform lymphangiomatosis (KLA) is an ultrarare disease characterized by abnormal lymphatic vessel proliferation due to hyperactivation of the Rat sarcoma virus (RAS) signaling pathway, resulting in multifocal lymphatic malformations (LMs) that can potentially involve multiple organ systems. Its distinctive histologic features include the presence of clusters of spindle cells expressing clusters of differentiation 31 (CD31), cluster of differentiation 34 (CD34), podoplanin (D2-40), prospero homeobox protein 1 (PROX1), and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1), along with abnormal lymphatic vessels. Sirolimus is recommended as a treatment option, particularly for patients without known mutations. This study aimed to examine the long-term therapeutic effects of sirolimus treatment in adult patients with KLA. - Source: PubMed
Publication date: 2026/04/23
Bilny-Paluch MagdalenaPiekarczyk PiotrBłasińska KatarzynaSzołkowska MałgorzataPolaczek MateuszRadzikowska Elżbieta