Monkey IL-6 ELISPOT kit, enzymatic staining

Price:

434.42 €

Known as:: Monkey Interleukin-6 ELISPOT reagent, enzymatic staining
Catalog number:: ct130-pr2
Product Quantity:: EUR
Category:: -
Supplier:: U-CyTech biosciences
Gene target:: Monkey IL-6 ELISPOT kit enzymatic staining

Related genes to: Monkey IL-6 ELISPOT kit, enzymatic staining

Gene:: CEBPB ^{NIH gene}
Name:: CCAAT enhancer binding protein beta
Previous symbol:: TCF5
Synonyms:: LAP, CRP2, NFIL6, IL6DBP, C/EBP-beta
Chromosome:: 20q13.13
Locus Type:: gene with protein product
Date approved:: 1991-02-27
Date modifiied:: 2018-02-23

Gene:: CEBPD ^{NIH gene}
Name:: CCAAT enhancer binding protein delta
Previous symbol:: -
Synonyms:: CRP3, CELF, C/EBP-delta, NF-IL6-beta
Chromosome:: 8q11.21
Locus Type:: gene with protein product
Date approved:: 1992-06-24
Date modifiied:: 2018-02-23

Gene:: ENTPD6 ^{NIH gene}
Name:: ectonucleoside triphosphate diphosphohydrolase 6
Previous symbol:: CD39L2, IL6ST2
Synonyms:: NTPDase-6, dJ738P15.3
Chromosome:: 20p11.21
Locus Type:: gene with protein product
Date approved:: 1998-03-20
Date modifiied:: 2019-02-28

Gene:: IL6 ^{NIH gene}
Name:: interleukin 6
Previous symbol:: IFNB2
Synonyms:: IL-6, BSF2, HGF, HSF
Chromosome:: 7p15.3
Locus Type:: gene with protein product
Date approved:: 1986-01-01
Date modifiied:: 2017-07-12

Gene:: IL6RP1 ^{NIH gene}
Name:: interleukin 6 receptor pseudogene 1
Previous symbol:: IL6RL1
Synonyms:: -
Chromosome:: 9q22.2
Locus Type:: pseudogene
Date approved:: 1991-08-18
Date modifiied:: 2014-11-19

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Related articles to: Monkey IL-6 ELISPOT kit, enzymatic staining

Fucoxanthin Ameliorates Polycystic Ovary Syndrome by Coordinated Modulation of NF-κB and Nrf2 Signaling: Evidence from a DHEA-Induced Mouse Model.
Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder characterized by aberrant nuclear factor kappa B (NF-κB)-mediated inflammation and impaired nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent antioxidant defense. This study represents the first investigation of fucoxanthin's concurrent regulatory effects on these opposing signaling axes in PCOS ovarian pathophysiology. Prepubertal female C57BL/6 mice (n = 40; postnatal day 25) were assigned to the following groups: control (sesame oil, 0.1 mL/day subcutaneously, n = 10), dehydroepiandrosterone (DHEA)-induced PCOS (6 mg/100 g body weight in sesame oil, n = 15), or DHEA+fucoxanthin (0.2% w/w in chow, n = 15) for 21 days. Estrous cyclicity was assessed by vaginal cytology. Ovarian morphology used hematoxylin-eosin staining. Serum testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-1 (IGFBP-1), and insulin were measured by enzyme-linked immunosorbent assay. Intraperitoneal glucose/insulin tolerance tests evaluated metabolism. Ovarian malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (T-AOC), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6) were quantified. Western blotting analyzed phosphoinositide 3-kinase (PI3K) p85α, protein kinase B (AKT), phospho-AKT, Nrf2, heme oxygenase-1 (HO-1), and NF-κB p65. Fucoxanthin restored estrous cyclicity in 60% of DHEA mice (vs. 0%), increased corpora lutea/large antral follicles, reduced testosterone/LH/IGF-1/insulin (P < 0.05), and elevated FSH/IGFBP-1. Insulin tolerance improved (P < 0.05). Ovarian MDA/TNF-α/IL-1β/IL-6 decreased (P < 0.05); SOD/CAT/T-AOC increased (P < 0.05). Fucoxanthin upregulated PI3K p85α, p-AKT/AKT, Nrf2/HO-1 and downregulated NF-κB p65 (P < 0.05). Collectively, these findings suggest that fucoxanthin coordinately modulates NF-κB suppression and Nrf2/HO-1 activation, establishing a novel multi-targeted therapy for PCOS. - Source: PubMed
Publication date: 2026/07/01
Ameen Sana Ismael
AQP4-IgG Dynamics and Exploratory Assessment of SERA-3 in Neuromyelitis Optica Spectrum Disorder Treated with Satralizumab.
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune condition driven by aquaporin-4 immunoglobulin G (AQP4-IgG). The current treatment paradigm focuses on mitigating clinical relapses and disability accumulation, leaving the underlying serological activity unaddressed. This study evaluated the capacity of satralizumab to achieve a comprehensive remission, as defined by the Serological, Relapse, and Accumulated-disability Remission (SERA-3) target. - Source: PubMed
Publication date: 2026/07/02
Yu MiaoxinLi XiangCui LeiJiao JinsongSun QingZhang YeqiongWang RenbinPeng DantaoHe YangJiao YujuanZhang Weihe
Dietary Chlorella, Spirulina, and acidifier modulate jejunal cytokine-related gene expression in broiler chickens.
Dietary microalgae and organic acidifiers are increasingly evaluated as non-antibiotic feed additives in poultry nutrition, but their effects on intestinal immune-related transcription remain incompletely defined. This study investigated the effects of dietary Chlorella vulgaris, Spirulina platensis, an organic-acid-based acidifier, and their combinations on jejunal cytokine-related mRNA expression in broiler chickens. Broilers were assigned to eight dietary treatments with three replicate pens per treatment and six birds per pen: basal diet control, acidifier, Chlorella, Spirulina, acidifier + Chlorella, acidifier + Spirulina, Chlorella + Spirulina, and acidifier + Chlorella + Spirulina. The acidifier was supplied at 0.1%, whereas Chlorella and Spirulina were included at 0.2%. At day 28, one bird was sampled from each replicate pen, yielding three independent pen-level biological replicates per treatment for RT-qPCR analysis. The relative expression of IFN-β, IFN-γ, IL-6, and IL-12 was quantified by USI-based TaqMan RT-qPCR and normalized to GAPDH. The treatments produced gene-specific and combination-dependent transcriptional responses. Chlorella alone reduced IL-6, IL-12, and IFN-γ expression, whereas the acidifier reduced IL-6 but increased IL-12 and IFN-β. The Chlorella + Spirulina and triple-combination groups showed broader upregulation across the measured cytokine-related transcripts. Because the study was limited to jejunal mRNA expression, used three pen-level biological replicates per treatment, and did not include cytokine protein quantification, intestinal histomorphometry, or microbiota profiling, the findings should be interpreted as preliminary transcriptional evidence rather than proof of improved gut health or functional immune modulation. - Source: PubMed
Publication date: 2026/07/01
Hosseini Seyed TalebTashakori FazilatLotfVarzi AminBishehKolaei Roya
Disrupted light exposure is associated with cardiac remodeling involving clock gene alterations and oxidative-inflammatory responses in rats.
Here we systematically compared the cardiovascular effects of continuous light (LL) and reversed 48-hour light-dark cycle (LD-DL) exposure in Sprague-Dawley rats over 20 weeks. Both disrupted light conditions were associated with significant cardiovascular dysfunction, including elevated blood pressure and increased heart rate, along with myocardial hypertrophy, cardiac enlargement, collagen fibrosis, and apoptosis. Notably, the LD-DL group exhibited more pronounced oxidative stress (elevated ROS, downregulated Nrf2) and inflammatory responses (enhanced inflammatory cell infiltration, upregulated IL-6 and IL-1β), whereas the LL group showed more pronounced cardiac structural remodeling despite moderate inflammation. Both paradigms were accompanied by suppressed melatonin levels and altered clock gene expression. These findings suggest that distinct light disruption patterns may be associated with cardiovascular injury through different mechanisms-LL predominantly characterized by hemodynamic parameters and structural remodeling, LD-DL preferentially linked to oxidative-inflammatory responses-highlighting the need for paradigm-specific therapeutic strategies. - Source: PubMed
Publication date: 2026/07/01
Li XuelingZhu QinChen HongyuHu XiaodiZhang YangHan LikaiJin Qinyang
3-O-p-coumaroylquinic acid and 4-O-p-coumaroylquinic acid from Hemerocallis citrina Baroni exert antidepressant effects via CA/Dopa/DA/NE and PKA/CREB/BDNF signaling pathways.
The ancient text "Compendium of Materia Medica" records that Hemerocallis citrina Baroni (daylily) was used for antidepressant, but its active components and mechanisms remain unknown. In this study, the H. citrina extract was initially fractionated into three parts, and only the 35% HCW (35% ethanol-eluted fraction of Hemerocallis citrina water extract, LILYANTIDEPRES) demonstrated significant antidepressant activity, notably increasing the levels of dopamine (DA), norepinephrine (NE), and brain-derived neurotrophic factor (BDNF) in the brain of depressed mice. It's also significantly reducing the IL-6 (Interleukin-6) and MDA (Malondialdehyde) levels, and improving the gut microbiota. The main components of the 35% HCW were identified as 3-O-p-coumaroylquinic acid (1) and 4-O-p-coumaroylquinic acid (2), which were also chemically synthesized. Both compounds exhibited significant antidepressant activity by increasing the levels of DA, NE, and BDNF in the brain of depressed mice and significantly reducing the levels of IL-6 and TNF-α (Tumor Necrosis Factor-α). A potential mechanism to elevate DA and NE levels in the depressed mice brain via the CA (coumaroylquinic acid)/Dopa/DA/NE pathway. Additionally, compounds 1 and 2 significantly increase BDNF levels through the PKA (Protein Kinase A)/CREB (cAMP Response Element-Binding Protein)/BDNF signaling pathway. This study provides the first elucidation of the antidepressant components of H. citrina and the mechanisms, laying the foundation for the development of antidepressant products and the high-value utilization of H. citrina resources. - Source: PubMed
Publication date: 2026/07/01
Jiang FayingQiu ZhengyueZhong JuhuaYe TianLiu JinghongZhu YishuoZhao LeweiChen SiyuChen HongbaoWang HaoboKang LinYang TongheLi ShuaiLiu SiZeng JianguoQing Zhixing

Monkey IL-6 ELISPOT kit, enzymatic staining

Related genes to: Monkey IL-6 ELISPOT kit, enzymatic staining

Related products to: Monkey IL-6 ELISPOT kit, enzymatic staining

Related articles to: Monkey IL-6 ELISPOT kit, enzymatic staining

Fucoxanthin Ameliorates Polycystic Ovary Syndrome by Coordinated Modulation of NF-κB and Nrf2 Signaling: Evidence from a DHEA-Induced Mouse Model.

AQP4-IgG Dynamics and Exploratory Assessment of SERA-3 in Neuromyelitis Optica Spectrum Disorder Treated with Satralizumab.

Dietary Chlorella, Spirulina, and acidifier modulate jejunal cytokine-related gene expression in broiler chickens.

Disrupted light exposure is associated with cardiac remodeling involving clock gene alterations and oxidative-inflammatory responses in rats.

3-O-p-coumaroylquinic acid and 4-O-p-coumaroylquinic acid from Hemerocallis citrina Baroni exert antidepressant effects via CA/Dopa/DA/NE and PKA/CREB/BDNF signaling pathways.