cDNA - Human Adult Normal Tissue: Skin
- Known as:
- complementary Desoxyribonucleic acid - Human Adult Normal Tissue: Skin
- Catalog number:
- c1234218
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Biochain
- Gene target:
- cDNA - Human Adult Normal Tissue: Skin
Related genes to: cDNA - Human Adult Normal Tissue: Skin
- Gene:
- CCL27 NIH gene
- Name:
- C-C motif chemokine ligand 27
- Previous symbol:
- SCYA27
- Synonyms:
- ALP, ILC, CTACK, skinkine, ESkine, PESKY, CTAK
- Chromosome:
- 9p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-07-30
- Date modifiied:
- 2016-10-05
Related products to: cDNA - Human Adult Normal Tissue: Skin
Related articles to: cDNA - Human Adult Normal Tissue: Skin
- The treatment of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome has largely focused on immunosuppression with little impact on the atopic manifestations of the disease. Dupilumab therapy has been used successfully in primary atopic diseases and immune regulatory disorders to control type 2 inflammation. Indeed, it has been reported in two prior IPEX cases, but in combination with immunosuppressive agents. Here, we are the first to report the clinical and immunologic impact of dupilumab monotherapy in IPEX. - Source: PubMed
Publication date: 2026/08/17
Alshanti MohammedMacDougall Matthew SGokbak Merve NidaRamachandran AkshayaAlzaabi Amna ArefAlexander Jessie LBacchetta RosaShendi Hiba Mohammed - Major depressive disorder (MDD) is a prevalent mental illness with a significant disease burden. It is characterized by immune-inflammatory dysregulation. - Source: PubMed
Chen TangcongLuo YueyangNiu MengqiLi JingLi MengdieZhang YingqianMaes Michael - Although circadian rhythms are critical regulators of cardiovascular physiopathology, their role in Takotsubo syndrome (TTS) remains poorly understood. This study aimed to investigate the influence of time of day on cardiac hypertrophy and inflammation in a mouse model of TTS induced by isoproterenol (ISO) administration. Female mice were injected with saline (Sal) or ISO at the beginning of the light (ZT0) or dark phase (ZT12). Our data show that mice treated with ISO at ZT12 developed more prominent cardiac hypertrophy and exhibited worse cardiomyocyte calcium handling. This was accompanied by an enhanced accumulation of leukocytes in the hearts of ISO/ZT12 compared with ISO/ZT0 mice. Flow cytometry analysis revealed an exacerbation in the number CD64Ly6CCCR2 monocytes/macrophages at ZT12, indicating a time of day influence on the inflammatory response following ISO administration. Of note, these differences were not secondary to differences in initial tissue injury as assessed by Evans Blue uptake by necrotic cells. However, cardiac expression of was significantly higher in the hearts of ISO/ZT12 than in the hearts of ISO/ZT0, suggesting the involvement of the CCL2/CCR2 signaling axis in the enhanced recruitment of monocytes. Finally, pharmacological and genetic strategies used to prevent CCR2-dependent recruitment of monocytes ameliorated the cardiac hypertrophy induced by ISO at ZT12, indicating that the CCL2/CCR2 signaling axis is crucial to the temporal-dependent effects of ISO. Taken together, our data show a previously unrecognized role of the time of day on cardiac inflammation following adrenergic overload. Using a mouse model of stress-inducible cardiomyopathy, our study reveals that enhanced monocyte influx to the injured heart during the dark phase exacerbates cardiac hypertrophy through activation of the CCL2/CCR2 axis. These findings extend current knowledge on the mechanisms underlying Takotsubo cardiomyopathy and highlight the potential for time of day-based therapeutic strategies. - Source: PubMed
Publication date: 2026/08/01
Sanches BrunoSouza-Neto FernandoPires Giovane L CAbramo HenriqueEliezeck MarcosScalzo Sérgio ASilva Nikolas SantosAmaral Flávio Almeidavan Berlo Jop HGuatimosim SilviaRocha-Resende Cibele - Atopic dermatitis (AD) is a chronic skin disorder driven by Th2 immune dysregulation, persistent inflammation, and epidermal barrier defects. Oxidative stress acts as a major upstream factor in this process, amplifying inflammatory signals and worsening disease severity. While current treatments relieve acute symptoms, long-term application is often constrained by side effects and poor barrier restoration, pointing to a need for safer, multifaceted alternatives. Here, we formulated a complex of extract (TJE) and GHK-Cu (Glycyl-L-histidyl-L-lysine copper(II)) complex and examined its anti-atopic and skin-regenerative properties using a TNF-α (Tumor necrosis factor-α)/IFN-γ (Interferon-γ)-stimulated HaCaT cell model. TJE decreased the expression of AD-related chemokines (TARC(Thymus and activation-regulated chemokine (CCL17)) and CTACK(Cutaneous T-cell-attracting chemokine (CCL27)) as well as IgE production, confirming the suppression of Th2-driven inflammation. An optimized 6:4 ratio (TJE:GHK-Cu) yielded the highest efficacy compared to individual treatments, indicating a synergistic interaction. TJE-GHK-Cu complex suppressed the transcription of key Th2 cytokines (IL-4, IL-5, IL-10, and IL-13) and promoted keratinocyte migration during wound healing assays. The formulation also displayed strong radical scavenging activity without compromising cell viability. These results demonstrate that the TJE-GHK-Cu complex provides simultaneous anti-inflammatory, antioxidant, and regenerative benefits, presenting a formulation warranting further investigation for managing AD. - Source: PubMed
Publication date: 2026/06/29
Jeon SoojinMaeng JihyeLee JiwonKim Young-MinNam Gaewon - Psoriasis patients were 4- 5 times more likely to have S. aureus colonize their skin. Psoriasis is caused by staphylococcal infection-induced keratinocyte death, which is maintained by elevated cytokine production of TNF-α and IFN-γ. The study sought to determine the association between the influence of gene expression of certain genes in psoriasis infections in the presence of S. aureus and their effect in Skin Cutaneous Melanoma infections. GEO with accession number (GSE207390) was used to acquire the data. The microarray test was used to perform this investigation. Six sets of keratinocytes, IL-17A, and TNF-α were cultivated together. Several kinds of bioinformatics tools were employed to fulfill the study's objective. Gene hub analysis of 34284 genes was scanned. Six genes demonstrated high expression rates were expressed during the metastatic stage: , , , , , and . and had the highest levels of expression. The expression of the gene rose in response to sun exposure, but the expression of the other genes remained same. The existence of cytokine groups with in keratinocytes influences the expression difference compared to the other groups. This work adds to our understanding of the molecular alterations that occur in the epidermis of psoriasis patients, as well as their relationship to comorbidities. - Source: PubMed
Ali-Adel DawoodMawj-Saddam Zabn