ABT-199 Bcl-2 inhibitor
- Known as:
- ABT-199 Bcl-2 suppressor
- Catalog number:
- a-1231
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- ActivBio Active Biochem
- Gene target:
- ABT-199 Bcl-2 inhibitor
Related genes to: ABT-199 Bcl-2 inhibitor
- Gene:
- BCL2 NIH gene
- Name:
- BCL2 apoptosis regulator
- Previous symbol:
- -
- Synonyms:
- Bcl-2, PPP1R50
- Chromosome:
- 18q21.33
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: ABT-199 Bcl-2 inhibitor
Related articles to: ABT-199 Bcl-2 inhibitor
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Publication date: 2026/08/04
Hou LixuanLi Lihua - Aquatic ecosystems are gradually being threatened by intensive agricultural practices, especially the extensive application of pesticides. Although pesticides such as organophosphates, carbamates, pyrethroids, phenylpyrazoles, and neonicotinoids are extensively used in agriculture for pest control, their entry into aquatic environments through runoff, leaching, and atmospheric deposition poses significant risks to nontarget organisms, including fish. This study provides a comprehensive understanding of pesticide-induced toxicity in fish, with particular emphasis on histopathological modifications and genetic alterations in the liver as critical biomarkers of cellular dysfunction, tissue injury, and toxicological responses. At the molecular level, the principal pathways affected included apoptosis (bcl2, caspase 3, 8, and 9), necroptosis (mlkl, ripk1, and ripk3), autophagy (atg and lc3), inflammation (cyp19a, nfκb, tnfα, and nox4), and DNA damage response pathways (atm, atr, tp53, and mdm2) indicating severe cellular stress, genomic instability, and tissue dysfunction induced by pesticide exposure. The major histopathological alterations observed in the liver included vacuolization, hemorrhage, vascular congestion, pyknotic nuclei, and inflammatory cell infiltration. This review highlights an integrated understanding of the association between hepatic histopathological manifestations and molecular responses in fish exposed to pesticides, providing insights into the mechanisms of hepatotoxicity and recognizing possible biomarkers for environmental monitoring and ecotoxicological risk assessment. These biomarkers play a crucial role in assessing the extent of aquatic contamination and understanding the implications of pesticide exposure on fish health, biodiversity, and ecosystem stability. Furthermore, this review underscores the urgent need for effective monitoring and mitigation strategies to safeguard aquatic life and maintain environmental integrity. - Source: PubMed
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Kumar ManojYadav SeemaDubey AasthaJain AnamikaSingh Shefalee - This study aimed to investigate the therapeutic potential of compound 18, an N-salicyloyl tryptamine derivative with established anti-neuroinflammatory and neuroprotective properties, in ameliorating male reproductive dysfunction induced by high-fat diet (HFD) in obese mice and to elucidate the underlying mechanisms. - Source: PubMed
Publication date: 2026/08/13
Fu ZhenhuiYang ChangleiHuang QiumeiPan YongyiWu HuiCai YunqianLei XiaocanYang FenglianHu Linlin - Alzheimer's disease (AD) represents a devastating neurodegenerative disorder globally. It is clinically characterized by cognitive dysfunction, predominantly learning and memory impairments, and is closely associated with cholinergic system damage. Osthol (OST), a bioactive compound with well-documented neuroprotective properties, has been shown to enhance learning and memory functions. However, the precise molecular mechanisms underlying its therapeutic effects on AD-related cognitive impairment remain unclear. This study elucidates the critical interplay between estrogen-cholinergic system imbalance and AD progression across distinct temporal windows in female AD models. By focusing on this sex-specific regulatory axis, we aimed to address a key gap in understanding AD pathogenesis and OST's targeted efficacy. We employed age-stratified 3×Tg-AD mice as an experimental model and utilized comprehensive behavioral paradigms to assess learning and memory functions. An age-dependent gradient of cognitive impairment, accompanied by varying degrees of neuropathological damage, was observed in 3×Tg AD mice across different age groups. OST significantly improved learning and memory performance in 3×Tg AD mice of all age groups. Western blotting, ELISA, and immunofluorescence staining indicated that OST treatment effectively alleviated damage to the estrogen-cholinergic-NGF axis through multiple synergistic mechanisms: upregulation of Acetylcholine (ACh), Choline acetyltransferase (ChAT), Tyrosine kinase-A (TrkA), and Nerve growth factor (NGF) expression; downregulation of Acetylcholinesterase (AChE) activity; and increased expression of Estradiol (E2), Estrogen receptor-α (ERα), and Estrogen receptor-β (ERβ). In addition, OST improved synaptic plasticity (Postsynaptic density protein-95 (PSD95), Synuclein (SYN), and Brain-derived neurotrophic factor (BDNF)), inhibited neuronal apoptosis (B-cell lymphoma-2 (Bcl-2) and Bcl-2-associated X protein (BAX)), and enhanced neurotransmitter signaling cascades (γ-aminobutyric acid (GABA), Glutamic acid (Glu), Epinephrine (E), and ACh). These findings provide new insights into the mechanisms of AD and support OST as a promising candidate for targeted AD therapy. - Source: PubMed
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Al-U'datt Doa'a G FTashtush AyssarAl-U'datt MuhammadTranchant Carole CAl-Masaed SaraJaradat Saied