Human Polyclonal HSP90AA1 Ab
- Known as:
- Human Polyclonal HSP90AA1 Antibody
- Catalog number:
- a0365
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- ABclonal
- Gene target:
- Human Polyclonal HSP90AA1
Related genes to: Human Polyclonal HSP90AA1 Ab
- Gene:
- HSP90AA1 NIH gene
- Name:
- heat shock protein 90 alpha family class A member 1
- Previous symbol:
- HSPC1, HSPCA
- Synonyms:
- Hsp89, Hsp90, FLJ31884, HSP90N
- Chromosome:
- 14q32.31
- Locus Type:
- gene with protein product
- Date approved:
- 1990-06-27
- Date modifiied:
- 2016-10-11
Related products to: Human Polyclonal HSP90AA1 Ab
Related articles to: Human Polyclonal HSP90AA1 Ab
- Proteomic profiling offers thorough insights into protein structure and function, as well as it acts as an essential approach for analyzing molecular changes at the tissue level. However, because of the proteome's diversity and dynamic nature, biomarker discovery remains challenging. By combining proteomics with bioinformatics, the level of understanding in relation to molecular interactions and disease processes can be improved. Through an integrative approach, few limitations can be addressed, thereby promoting proteomic profiling for the discovery of new therapeutic targets and novel biomarkers for a variety of disorders. - Source: PubMed
Publication date: 2026/06/18
Rao Bounika EsvanthNair Anju MRamesh PreethiRamshankar VijayalakshmiGopinath SAbhinand P ANdkoraj ArtnoraMazur MartaWarnakulasuriya SamanCatakapatri Venugopal Divyambika - Breast cancer is the most prevalent cancer globally, with limited efficacy of traditional therapies and high drug resistance. Maslinic acid (MA) has broad-spectrum anti-tumor activity. This study aimed to investigate whether MA exerts its anti-tumor effects in breast cancer by inducing ferroptosis and autophagy. - Source: PubMed
Publication date: 2026/04/30
Li YifeiZhou ShugongLi RuobingLiu YingshuoGuo XiaohuiPeng LinyingLiu YanLi MiZhao LinaZhang YunfengCai HaifengHu Fen - Atopic dermatitis (AD), the most common chronic inflammatory dermatosis, currently lacks definitive curative treatments. This study aimed to identify potential drug targets for AD through an integrative genomic approach. - Source: PubMed
Publication date: 2025/10/05
Zhang YuTeng ZiyueZhao JuyanTu YunhuaFu LanLi Qi - Shengxian Quyu decoction (SXQY) has been suggested as a potential therapeutic strategy for heart failure (HF), but its therapeutic mechanisms remain unclear. This study investigated the therapeutic effects and underlying mechanisms of SXQY in HF. A rat model of HF was induced by transverse aortic constriction (TAC) and treated with SXQY. Cardiac function was assessed by transthoracic echocardiography, and myocardial structure and fibrosis were evaluated using hematoxylin and eosin and Masson's trichrome staining. Serum samples were analyzed by untargeted metabolomics using ultra-performance liquid chromatography-tandem mass spectrometry. Blood-entering components were mapped to targets, and intersecting HF-related targets were analyzed using protein-protein interaction (PPI) network analysis, followed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. SXQY significantly improved cardiac function in TAC rats, as evidenced by decreased left ventricular internal diameter in diastole and left ventricular posterior wall thickness in diastole and increased left ventricular ejection fraction, and alleviated myocardial hypertrophy, inflammation, and fibrosis. A total of 563 blood-entry compounds were identified (367 prototypes and 196 metabolites), with 5 key active compounds identified in the Traditional Chinese Medicine Systems Pharmacology database corresponding to 63 targets. Network analysis revealed 44 overlapping genes, with Formononetin, Timosaponin BII, and Sinensetin as core components, and PTGS2, PPARG, and HSP90AA1 as hub targets. PPI analysis further identified key genes including ESR1, PTGS2, PPARG, HSP90AA1, JUN, and 15 additional genes. KEGG analysis indicated that SXQY mainly acts via Ca, phosphatidylinositol 3-kinase-protein kinase B, cyclic adenosine monophosphate, and inflammation- and hormone-related pathways. In conclusion, SXQY exerts protective effects against HF by improving cardiac function and attenuating myocardial remodeling through multicomponent, multitarget, and multipathway mechanisms. - Source: PubMed
Publication date: 2026/05/29
Li DongxiaZhou XinyiTao ShiyiXiong HaoZheGao XuefeiXiao XiangHuang LiShao MingjingYang Deshuang - The impact of polycyclic aromatic hydrocarbons (PAHs) and metals on aging biomarkers-telomere length (TL) and mitochondrial DNA copy number (mtDNAcn)- has been investigated separately. However, their combined effects, particularly in highly exposed occupational populations, remain unexamined, despite their frequent co-occurrence in environmental settings. This study measured baseline urinary and blood samples from 867 coke oven workers at baseline for 33 chemical pollutants and mtDNAcn, and assessed leukocyte TL at both baseline and follow-up. The combined effect of metals and PAHs on aging biomarkers was evaluated using weighted quantum sum (WQS) regression and Bayesian kernel machine regression (BKMR), and mediation analyses were also conducted. Multiple linear regression incorporating 33 pollutants and least absolute shrinkage and selection operator (LASSO) regression were used to identify individual exposures with significant effects, while restricted cubic splines were applied to explore potential nonlinear dose-response relationships. We observed that both the WQS and BKMR indicated that 33 chemical mixtures exposure was significantly negatively associated with the TL ratio (follow-up/baseline) and positively associated with baseline mtDNAcn. Urinary 1-hydroxypyrene, molybdenum, selenium (Se), and barium were identified as the major contributors. Furthermore, oxidative stress and inflammation mediated the link of major individual pollutants as well as the chemical mixture to biological aging. Network toxicology analysis identified and as core molecular targets underlying the effect of Se on TL regulation. To our knowledge, this is the first study to investigate the joint effects and underlying mechanisms of co-exposure to PAHs and metals on biomarkers of biological aging. - Source: PubMed
Publication date: 2026/05/28
Mu MinXiong ShikaiGuan XinYu LiliangGuo HuanLai Xuefeng