Human Polyclonal EEF1B2 Ab
- Known as:
- Human Polyclonal EEF1B2 Antibody
- Catalog number:
- a6580
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- ABclonal
- Gene target:
- Human Polyclonal EEF1B2
Related genes to: Human Polyclonal EEF1B2 Ab
- Gene:
- EEF1B2 NIH gene
- Name:
- eukaryotic translation elongation factor 1 beta 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-13
- Date modifiied:
- 2015-09-11
Related products to: Human Polyclonal EEF1B2 Ab
Related articles to: Human Polyclonal EEF1B2 Ab
- Cytoskeletal remodeling, including microtubule severing, is essential for neurite growth and structural plasticity. However, the regulatory mechanisms that control the microtubule-severing activity of katanin A1 (KATNA1) remain incompletely understood. Here, we identify a novel interaction between eukaryotic translation elongation factor 1 beta (EEF1B2) and KATNA1 and show that this protein pair regulates microtubule dynamics and neurite outgrowth. Proteomic screening and biochemical validation (GST pull-down and co-immunoprecipitation) demonstrated that EEF1B2 interacted with KATNA1, with strongest binding mapped to the KATNA1 AAA + ATPase domain. In COS7 cells, EEF1B2 potentiated KATNA1-dependent microtubule severing, whereas EEF1B2 knockdown attenuated KATNA1-driven microtubule loss. In primary cortical neurons, EEF1B2 enhanced KATNA1-induced neurite outgrowth and branching, and these effects were KATNA1-dependent. Together, these findings identify EEF1B2 as a modulator of KATNA1 activity and provide new insight into the molecular mechanisms governing microtubule remodeling and neurite growth. - Source: PubMed
Publication date: 2026/04/17
Wu ZengzhiYan JiajieDeng TingtingDong JiaoMeng ZhichaoZhu JiehaoChen MuZhang GuoweiTan WeiTan Minghui - - Source: PubMed
Publication date: 2026/01/14
Ketenci-İşlek SerapÜrel-Demir GizemUtine Gülen EdaŞimşek-Kiper Pelin Özlem - Colorectal cancer often develops from adenomas over years, necessitating early intervention. Myeloid-derived suppressor cells (MDSCs) are major immune suppressive cell types in colon cancer development from adenomas through early inflammation-induced emergency myelopoiesis. Cannabidiol (CBD) is reported to function in psychosis, coronavirus infection and some cancers through immune regulation. However, its target and underlying mechanisms in colorectal adenomas are unknown. - Source: PubMed
Publication date: 2026/01/03
Pan JieZhao LixinDu HaojieZhu YuyuSun XiaofanXu QiangCheng HaiboChen HongqiSun Yang - Kaposi's sarcoma (KS) is a locally aggressive, multicentric tumor. RNA-binding proteins (RBPs) are pivotal for post-transcriptional regulation in various tumors. However, the aberrantly expressed RBP genes and their regulatory patterns in KS remain unclear. This study aimed to identify relevant RBP genes in KS and assess the potential functions and molecular interactions of RPS27, a dysregulated RBP in KS tissues, METHODS: Matched KS lesions and normal control tissues from ten patients were chosen for the study. Differentially expressed genes (DEGs) were first identified by RNA-sequencing, and results were validated through an independent public RNA-seq dataset (GSE147704). Among the DEGs, RBPs were selected for further analysis, with RPS27 chosen for detailed investigation due to its dysregulation in KS tissues. RT-qPCR and immunohistochemistry were employed to validate RPS27 expression. Cellular experiments were conducted for dysregulated RPS27 to explore its functions. Additionally, improved RNA immunoprecipitation (iRIP)-seq was performed to investigate potential binding interactions of RPS27 in KS. - Source: PubMed
Publication date: 2025/02/27
Zhang JingzhanWang PengLi TingtingLuo DongQu YuanyuanDing YuanKang Xiaojing - Spermatogonial stem cells (SSCs) are essential for male fertility, maintaining sperm production throughout life. While mouse SSCs have been studied extensively, the mechanisms regulating human SSCs are less understood. - Source: PubMed
Publication date: 2024/08/23
Huang ZenghuiLi NingJi XirenZhou DaiWang RuijunZhao XingguoWang ShuangyaoZhang HuanHuang ChuanLin Ge