Human Polyclonal MLH1 Ab
- Known as:
- Human Polyclonal MLH1 Antibody
- Catalog number:
- a0254
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- ABclonal
- Gene target:
- Human Polyclonal MLH1
Related genes to: Human Polyclonal MLH1 Ab
- Gene:
- MLH1 NIH gene
- Name:
- mutL homolog 1
- Previous symbol:
- COCA2
- Synonyms:
- HNPCC, FCC2, HNPCC2
- Chromosome:
- 3p22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-24
- Date modifiied:
- 2019-04-23
Related products to: Human Polyclonal MLH1 Ab
Related articles to: Human Polyclonal MLH1 Ab
- Anti-Hu paraneoplastic neurological syndromes are most commonly associated with small-cell lung cancer and are rarely reported in colorectal malignancy. A 43-year-old man presented with progressive sensory neuropathy and weight loss. Evaluation revealed positive serum anti-Hu antibodies, markedly elevated cerebrospinal fluid protein, and imaging demonstrating an ascending colon mass. Right hemicolectomy confirmed Stage IIIA (pT3N1aM0) moderately differentiated adenocarcinoma, with mismatch repair-deficient (loss of MLH1 and PMS2) and B-Raf proto-oncogene, serine/threonine kinase wild-type tumor profile. Despite a significant family history, the patient had not undergone recommended early colorectal screening. Postoperative circulating tumor DNA was negative, and the patient was placed on active surveillance; however, neurological symptoms persisted, and immunomodulatory therapy access was initially limited. This case highlights a rare association between anti-Hu-associated myeloneuropathy and early-onset colon cancer and underscores the importance of malignancy evaluation in unexplained sensory neuronopathy. - Source: PubMed
Publication date: 2026/06/30
Hussain SanaBalak Felix Primo RadegondeMuratova AikenHussain AzharAperna FnuButt Tooba ShaukatMann PrachiConti Ricardo - Lynch syndrome (LS) is an autosomal dominant hereditary cancer predisposition syndrome associated with colorectal and extracolonic malignancies. Metachronous colorectal carcinomas are well recognized, whereas pancreatic involvement by metastatic colorectal carcinoma is rare and diagnostically challenging. We report the case of a 58-year-old male patient with a strong family history of colorectal carcinoma and an 18-year history of multiple metachronous colorectal malignancies who developed a pancreatic body-tail mass during oncologic surveillance. Histology showed a high-grade malignant epithelial neoplasm with solid/nested architecture and extensive necrosis. Immunohistochemistry (IHC) demonstrated diffuse SATB2 positivity and loss of MLH1/PMS2 expression, with retained MSH2/MSH6. The findings favored metastatic colorectal carcinoma involving the pancreas in the setting of clinically suspected Lynch syndrome. This case emphasizes the importance of clinicopathologic correlation, cautious interpretation of MMR deficiency, and long-term multidisciplinary surveillance. - Source: PubMed
Publication date: 2026/05/31
Jikurashvili MananaNarimanishvili GiorgiGotsadze IlyaMariamidze ArmazChechelashvili DavidGendzekhadze MariamMatcharashvili SopikoDatunashvili GiorgiTchokhuri Salome - To investigate the clinicopathological features, immunophenotype and molecular genetics of superficial serrated adenoma (SuSA), and to characterize their diagnostic features. Ten SuSA cases diagnosed at the First Affiliated Hospital with Nanjing Medical University, Nanjing, China from January 2023 to June 2025 were collected. Their histological morphology was examined. The expression of CK7, CK20, Ki-67, β-catenin, C-MYC and mismatch repair (MMR) proteins, including PMS2, MLH1, MSH2 and MSH6, was assessed using immunohistochemistry, while KRAS and BRAF mutations were studied in 10 cases by using amplification retardation mutation system PCR. Relevant literature was also reviewed. Among the 10 patients, 5 were male and 5 were female, aged 62.0 (53.5, 72.3) years. The tumors were located in sigmoid colon (7 cases), rectum (2 cases), and descending colon (1 case). There were 9 cases of isolated SuSA that had no synchronous colonic lesions, and 1 case of SuSA with synchronous traditional serrated adenoma (TSA). Endoscopically, isolated SuSA was usually presented as small sessile polyps or large flat lateral lesions. Histologically, it showed a characteristic "double-story building" structure, with serrated changes on the surface and adenomatous structures in the deep. The SuSA with synchronous TSA showed TSA-like changes on the surface/tip of the tumor. The serrate region of the surface layer was positive for CK20 and negative for Ki-67, while the adenomatous region of the middle and lower layers showed high expression of C-MYC and Ki-67, nuclear staining of β-catenin, and no expression of CK7 and CK20. The expression of all MMR proteins (MMR intact phenotype) was found in all cases. Molecular profiling of 10 cases showed that 9 tumors harbored KRAS mutations and 1 tumor harbored a BRAF mutation. SuSA is a rare serrated colorectal lesion that predominantly arises in the left colon. It shares overlapping histological features with hyperplastic polyps, TSA and sessile serrated lesions. It is characterized by superficial serration and deep adenomatous changes, which easily lead to misdiagnosis and missed diagnosis. Understanding its histological features and immunohistochemical profile facilitates its diagnosis and differential diagnosis, including CK20 positivity and Ki-67 negativity in the superficial layer, and high Ki-67 expression with negative CK20 staining in the deep layer. KRAS gene mutation is also an important diagnostic feature. - Source: PubMed
Zhuo S SHua H JYang Y FChen GZhang YBai R MZhang Z H - Performing germline genetic testing of family members following the identification of an individual with a pathogenic variant in a cancer predisposition gene, a process known as cascade testing, is a critical step in maximizing the preventive benefit of genetic testing for hereditary cancer. - Source: PubMed
Publication date: 2026/06/01
Namey EliaHorton CarolynDudley BethCarraway CassidyKomala TimothyMilliard CarrieNamey TaraKarloski EveBrand Randall - We report a case of mismatch repair protein deficient (MMRd) and high microsatellite instability (MSI-H) GIST that is exceedingly rare. The patient is an elderly male who presented with abdominal discomfort and poor appetite. Investigations revealed a gastric GIST (CD117 and DOG1 positive, SDH expression retained), spindle cell type, 22 cm in size with 23 mitoses per 5mm. Few small metastatic nodules were also present in the liver. Next generation sequencing (NGS) revealed a KIT exon 11 c.1668_1724del, p.(Trp557_Gln575del) variant, MSI-H phenotype and tumour mutational burden (TMB) of 15.7 mutations per megabase (Mb). MMR protein immunohistochemistry showed loss of MLH1 and PMS2 expression. The NGS also showed a MLH1 exon 17 c.1946del, p.(Pro649fs) variant. No germline testing was performed. MSI testing by MSI PCR, however, showed a microsatellite stable result. This highlights how MSI PCR may not be sufficiently sensitive in detecting MSI-H status in tumour types outside of colorectal carcinomas. - Source: PubMed
Publication date: 2026/06/29
Tay Timothy Kwang YongTan Gek SanLee Say HweeChan Chee SengNg Jeremy Wee KiatChen Eileen XueqinTay Amos Zhi EnQuesada Urera MarianaKhoo Wui SengLim Tony Kiat Hon