EGF Phospho-Specific Array includes 214 highly specific and well-characterized phosphorylation antibodies related to the EGF family of proteins.
- Known as:
- EGF Phospho-Specific Array includes 214 very specific well-characterized phosphorylation antibodies related EGF family proteins.
- Catalog number:
- AA0023
- Product Quantity:
- 2 Pieces/Box
- Category:
- -
- Supplier:
- Abno
- Gene target:
- EGF Phospho-Specific Array includes 214 highly specific and well-characterized phosphorylation antibodies related the family proteins.
Ask about this productRelated genes to: EGF Phospho-Specific Array includes 214 highly specific and well-characterized phosphorylation antibodies related to the EGF family of proteins.
- Gene:
- MAPK4 NIH gene
- Name:
- mitogen-activated protein kinase 4
- Previous symbol:
- PRKM4
- Synonyms:
- Erk3-related, Erk4
- Chromosome:
- 18q21.1-q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-08
- Date modifiied:
- 2018-02-13
Related products to: EGF Phospho-Specific Array includes 214 highly specific and well-characterized phosphorylation antibodies related to the EGF family of proteins.
Related articles to: EGF Phospho-Specific Array includes 214 highly specific and well-characterized phosphorylation antibodies related to the EGF family of proteins.
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Publication date: 2026/07/15
Jia MengYu Shi-LiSun Ping-Li - Alzheimer's disease (AD) is characterized by neuroinflammation, yet the impact of concurrent systemic infections on the AD brain remains poorly understood. We investigated the molecular mechanisms underlying the central nervous system response to systemic infections in AD by analyzing RNA sequencing data generated in the prefrontal cortex from 202 post-mortem donors (113 AD, 89 controls), where we stratified by the presence of a respiratory infection at the time of death. We identified 763 significant differentially expressed genes (DEGs) between AD and controls without infection, which were enriched for oxidative phosphorylation and neurodegenerative pathways. In contrast, 122 DEGs distinguished AD from controls during infection, with 57 genes uniquely altered in AD in the presence of infection, including MAPK4, VAV3, and POU3F4, implicating infection-dependent mechanisms of vascular and immune regulation. Pathway activity analysis revealed that infection in AD suppresses some immune and vascular pathways, while enhancing transcriptional and developmental programs. Weighted gene co-expression network analysis uncovered three key modules: one module strongly associated with AD, enriched for aging and signal transduction; one module linked to both AD and infection, highlighting cytoskeletal remodeling and host-pathogen interactions; and one module specific to infection, enriched in astrocytes, pericytes, and endothelial cells, implicating blood-brain barrier dysfunction. These findings suggest that systemic respiratory infections reshape transcriptional programs in the AD brain, dampening immune effector pathways and engaging vascular and host-pathogen processes in blood-brain-barrier-associated cell types. Our results highlight the complex interplay between systemic infection, neuroinflammation, and vascular responses in AD. - Source: PubMed
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