PGLS (Human) IP-WB Antibody Pair
- Known as:
- PGLS (Human) IP-Western Blot Antibody Pair
- Catalog number:
- H00025796-PW1
- Product Quantity:
- 1 Set
- Category:
- -
- Supplier:
- Abno
- Gene target:
- PGLS (Human) IP- Antibody Pair
Related genes to: PGLS (Human) IP-WB Antibody Pair
- Gene:
- PGLS NIH gene
- Name:
- 6-phosphogluconolactonase
- Previous symbol:
- -
- Synonyms:
- 6PGL
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2000-01-20
- Date modifiied:
- 2015-08-25
Related products to: PGLS (Human) IP-WB Antibody Pair
Related articles to: PGLS (Human) IP-WB Antibody Pair
- Body size represents one of the most fundamental adaptive traits in mammals, but the genetic architecture underlying the extensive body size diversification observed in the Felidae family remains largely uncharacterized. Here, we present the first comprehensive comparative genomic analysis of Felidae body size evolution using high-quality reference genomes from 17 species, including two newly reannotated genomes. Using phylogenetic generalized least squares (PGLS) analysis, we identified 35 body-size-associated genes (BAGs), most of which are functionally implicated in skeletal development, thyroid hormone synthesis, and lipid metabolism. Functional enrichment analysis revealed that positively selected genes (PSGs) in large-bodied Felidae were predominantly enriched in DNA repair pathways, whereas PSGs in small-bodied Felidae were primarily involved in energy metabolism and lipid metabolism processes. In summary, the adaptive evolution of both core signaling pathways and key functional genes has jointly driven body size diversification in Felidae. This study uncovers new molecular insights into how mammalian body size evolves, while also generating a valuable genomic dataset for subsequent functional research. - Source: PubMed
Publication date: 2026/09/22
Zhao ShihuXia TianMei XuesongQiu ChenZhang YingZhao ChaoWu XiaoyangGao XiaodongFang JiaohuiDing JianqunWang ZhenglongYang XiufengZhang Honghai - is an emerging respiratory pathogen primarily found in soil environments, yet its genomic architecture and evolutionary strategies remain poorly characterized. Here, through pan-genomic and functional analysis of 242 isolates, we reveal an open pan-genome driven by extensive horizontal gene transfer and marked functional divergence between core and accessory genomes. We identify a phylogenetically distinct lineage, designated as putative serogroup 3 (sg3), recovered from Chinese environments. This lineage diverges from canonical serogroups 1 and 2 through genome reduction (mean size 4.01 Mb), absence of plasmids, and a truncated O-antigen biosynthesis cluster lacking a key N-acetyltransferase-encoding gene (orf9). infection models across multiple human cell lines show that sg3 elicits increased host cell death and elevated proinflammatory cytokine transcription in epithelial cells compared to sg1 and sg2. Phylogenetically corrected association analyses revealed no significant link between this phenotype and individual accessory virulence factors. Instead, rank-transformed phylogenetically generalized least squares (PGLS) regression demonstrated a significant positive association with expansion of the mobilome (COG X), while intracellular trafficking (COG U) and defense (COG V) repertoires were contracted. These findings reveal a distinct pathogenic profile in sg3 that differs from the canonical serogroups, characterized by heightened inflammatory activation rather than immune evasion. Our work advances the understanding of population structure, challenges the reductionist utility of traditional serogrouping, and highlights the potential need for revised diagnostic considerations as well as continued surveillance of lineages displaying enhanced cytotoxicity and proinflammatory responses, which may be associated with mobilome expansion.IMPORTANCE is an understudied yet emerging cause of Legionnaires' disease, with a distinct soil-based ecology. Using comparative pan-genomics and functional infection assays across 242 isolates (including 39 newly sequenced from China), we identify a putative novel serogroup (sg3) that has undergone marked genome reduction (4.01 Mb) and completely lost plasmids, contrasting with near-ubiquitous plasmid carriage in sg1/sg2. Despite its streamlined genome, putative sg3 exhibits enhanced cytotoxicity in all tested human cell lines and elevated proinflammatory cytokine expression, particularly in epithelial cells. These phenotypes are not explained by individual virulence genes but are significantly associated with mobilome (COG X) expansion. Our findings question the assumption that genome reduction necessarily diminishes pathogenic potential and suggest that higher-order genomic restructuring, potentially linked to mobilome expansion, may be associated with increased inflammatory responses. Furthermore, they highlight the potential need for continued surveillance and consideration of revised diagnostic approaches to include this rare but possibly underdiagnosed lineage. - Source: PubMed
Publication date: 2026/09/22
Xu Jun-WeiHe Yuan-TongZhou XuefuZhan Xiao-Yong - Stereotactic radiosurgery and photon therapy for the locoregional management of head and neck paragangliomas (HNPGLs) have been shown to provide long-term tumor control and symptomatic relief. We report proton therapy (PT) outcomes for HNPGLs at a single institution and describe stereotactic radiosurgery (SRS) and intensity-modulated radiation therapy (IMRT) outcomes as institutional context for modality selection. The primary goal is to report outcomes including tumor control, toxicity, and overall recovery, while evaluating differences across radiation modalities. - Source: PubMed
Publication date: 2026/08/17
Abbasi Aleena ALustig Robert ADorsey Jay FGrady Sean MLee John Y KKurtz Goldie AShabason Jacob ECengel Keith ABigelow Douglas CBrant Jason ARuckenstein Michael JRassekh Christopher HNathanson Katherine LRaper AnnaHuan YonghongAlonso-Basanta Michelle - Recognizing lineages is a central challenge in plant systematics, making it essential to explore multiple analytical tools. In this context, this study investigates how frond shape can assist in discriminating against lineages within the Scaly clade of Microgramma (Polypodiaceae), and tests whether the integration of multiple lines of evidence enables a more consistent recognition of lineages than exclusively macromorphological approaches. - Source: PubMed
Publication date: 2026/09/10
Mendonça Niksoney AzevedoAljahara JulianaSilva D Victor Souza EAlmeida Thaís Elias - Pheochromocytomas and paragangliomas (PGLs) are rare neural crest-derived neuroendocrine neoplasms with highly variable clinical behavior and limited therapeutic options in metastatic disease. From a pathologic perspective, diagnosis and risk assessment have traditionally relied on histomorphology and immunohistochemistry. However, conventional parameters remain insufficient to reliably predict biological behavior. Over the past decade, genomic and transcriptomic profiling have refined molecular classification, yet genotype-based stratification alone does not fully explain heterogeneity in tumor progression, immune composition, or treatment response. This review examines the evolution of experimental and analytical approaches to PGLs through a pathology-centered lens. We first discussed how advances in developmental biology and molecular classification have reshaped understanding of tumor heterogeneity beyond morphology. We then highlighted the growing recognition of the tumor microenvironment as a critical determinant of tumor behavior. In this context, spatially resolved protein profiling, including multiplex immunofluorescence, has emerged as an important extension of traditional immunohistochemistry, enabling simultaneous visualization of immune and tumor cell populations within preserved tissue architecture. These approaches provide functional insight that cannot be derived from bulk genomic analyses alone. Despite these advances, translation into therapeutic innovations has been hampered by the lack of physiologically relevant human model systems. Early 2-dimensional cell cultures and rodent models provided foundational mechanistic insights but failed to recapitulate human tumor architecture and microenvironmental interactions. The recent establishment of patient-derived PGL organoids represents a significant step forward, preserving chromaffin lineage features and enabling ex vivo pharmacologic interrogation. Taken together, the progression from histopathological assessment to spatial immune profiling and advanced 3-dimensional human modeling defines a conceptual framework in which functional therapeutic testing may become integrated into future pathology-driven translational research in PGLs. - Source: PubMed
Publication date: 2026/09/03
de Bresser Carolijn J Mde Krijger Ronald R