Polyclonal Rabbit M CCNB1 Antibody
- Known as:
- Polyclonal Rabbit M CCNB1 Antibody
- Catalog number:
- abx34751
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Abbexa
- Gene target:
- Polyclonal Rabbit CCNB1 Antibody
Related genes to: Polyclonal Rabbit M CCNB1 Antibody
- Gene:
- CCNB1 NIH gene
- Name:
- cyclin B1
- Previous symbol:
- CCNB
- Synonyms:
- -
- Chromosome:
- 5q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-12-10
- Date modifiied:
- 2016-10-05
Related products to: Polyclonal Rabbit M CCNB1 Antibody
Related articles to: Polyclonal Rabbit M CCNB1 Antibody
- Lactate, an energy source and metabolic by-product, has been implicated in cancer progression, but its role in colorectal cancer (CRC) remains incompletely understood. This study investigated the clinical significance, biological effects, and transcriptomic responses of CRC cells to lactate. In human CRC specimens, lactate levels were positively associated with advanced clinical stage and poorer disease-free survival. Functional assays showed that lactate promoted malignant cellular behaviors in both SW480 and HCT116 cells, while pH-control experiments suggested that these effects were not merely due to extracellular acidification alone. RNA sequencing in SW480 cells identified 1,418 differentially expressed genes after lactate treatment. GO and KEGG analyses revealed alterations in multiple metabolic and signaling pathways. qRT-PCR validated the alterations of representative genes, including HK2, VEGFA, JUNB, CCNB1, MAPK4, and COX2. In addition, flow cytometry showed activation of NF-κB and HIF-1α signaling following lactate treatment, and pharmacological inhibition of either pathway significantly attenuated the lactate-induced malignant phenotypes. Together, these findings provide transcriptomic and functional evidence that lactate promotes malignant phenotypes in CRC cells and offer exploratory mechanistic insights into the involvement of NF-κB and HIF-1α signaling. - Source: PubMed
Publication date: 2026/05/02
Li ShujuanFeng ShiweiLi XuannaSu RanDeng JinhuaCheng SijingHou Yujie - -Aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the central nervous system and is involved in the development of neural tissue as well as the regulation of its functions. Meanwhile, GABA has also been demonstrated to confer multiple physiological benefits, including alleviating stress and improving metabolic homeostasis. This study investigated GABA effects on proliferation, differentiation, and temperature stress protection of bovine skeletal muscle satellite cells (BSCs). - Source: PubMed
Publication date: 2026/04/14
Manzoor AbidNaseem SajidaFu ZhiqiRuan ChaohuiLiu XuYan ChunriChoi SeonghoLi Xiangzi - Malachite green (MG), a synthetic dye, has turned into a major risk to human health, because of its toxicity of teratogenic, genotoxic, carcinogenic, and immunosuppressive properties. And the result of ADMETLAB 2.0 platform prediction shows that MG is highly toxic to the respiratory system in our study. However, no study has conducted to verify and explain the association between MG and lung adenocarcinoma (LUAD). In the current investigation, a total of 34 candidate target genes that might be involved in MG-mediated modulation in LUAD were identified and screened through integrated machine learning algorithms, including LASSO regression and random forest analysis. Subsequent functional annotation revealed that these genes were predominantly enriched in biological processes associated with the cell cycle. Meanwhile, pathway analysis indicated that the majority of these genes were closely linked to the p53 signaling pathway. Furthermore, molecular docking simulation validated that MG could stably and specifically bind to TP53, CCNB1, and MAPK1 proteins. In summary, our results demonstrated that MG may participate in the tumorigenesis and progression of LUAD, mainly by regulating the cell cycle via the p53 and MAPK signaling pathways. Among these, TP53, CCNB1, and MAPK1 could act as crucial candidate targets in MG‑mediated LUAD development. These findings provide novel insights into the molecular mechanisms underlying the role of MG in LUAD, and lay a theoretical basis for the future prevention and targeted therapy of LUAD. - Source: PubMed
Qu ShaoboYang ZhichaoZhang ShuaiHou Yongwang - Carbohydrate responsive element-binding protein (ChREBP) is a glucose-activated transcription factor implicated in metabolic regulation and β-cell proliferation. Although in vitro studies have suggested that ChREBP promotes glucose-stimulated β-cell proliferation, its in vivo role under physiological and pathophysiological conditions remains unclear. - Source: PubMed
Publication date: 2026/04/15
Kubota SodaiBanno SeiyaIizuka KatsumiTsuchida HiromiKubota-Okamoto SakiSakurai TeruakiTakahashi YoshihiroImaizumi ToshinoriKato TakehiroHorikawa YukioTsunekawa ShinUsui RyotaTatsuoka HisatoTokumoto ShinsukeMurakami TakaakiFujiwara YuukaKuwata HitoshiYamazaki YujiYamada YuichiroSeino YutakaYabe Daisuke - Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial hyperplasia, persistent inflammation, and progressive joint destruction. Ginkgetin (GK), a biflavonoid derived from Ginkgo biloba, exhibits strong anti-inflammatory and antioxidant properties. However, its therapeutic potential and underlying molecular mechanisms in RA remain insufficiently understood. - Source: PubMed
Publication date: 2026/04/11
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