SERPINA3 (Human) Matched Antibody Pair
- Known as:
- SERPINA3 (Human) Matched Antibody Pair
- Catalog number:
- H00000012-AP51
- Product Quantity:
- 1 Set
- Category:
- -
- Supplier:
- Abno
- Gene target:
- SERPINA3 (Human) Matched Antibody Pair
Related genes to: SERPINA3 (Human) Matched Antibody Pair
- Gene:
- SERPINA3 NIH gene
- Name:
- serpin family A member 3
- Previous symbol:
- AACT
- Synonyms:
- ACT
- Chromosome:
- 14q32.13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-04
Related products to: SERPINA3 (Human) Matched Antibody Pair
Related articles to: SERPINA3 (Human) Matched Antibody Pair
- Renal transplant patients (RTPs) receiving immunomodulatory therapy are at increased risk of severe complications from COVID-19 and other infections. This study aimed to identify immune and proteomic biomarkers associated with COVID-19 in RTPs to improve disease characterization and support future diagnostic and therapeutic strategies. - Source: PubMed
Publication date: 2026/06/12
Alaiya AyodeleAl-Mozaini MahaShinwari ZakiaAlzayed AbdulazizAlsharif IbtihajAllam RababBakheet RazanAlharbi LaylaAlotaibi Fahad OjabIdris JumanaObeid Dalia AAlshukairi AbeerMárquez-Méndez MarcelaCerda-Flores Ricardo MAlmojalli Hamad A - Metabotropic glutamate receptors (mGluRs) are of increasing interest in the pathophysiology and treatment of schizophrenia. In the nucleus accumbens (NAc), presynaptic mGluRs (largely group II and III) can regulate the activity of medium spiny neurons (MSNs) through control of glutamate release from extra-striatal regions. Given that inflammatory pathways can modulate glutamate and dopamine signalling, inflammation may influence these mGluR-mediated mechanisms in schizophrenia. Cellular expression of mGluR mRNAs in the NAc was investigated using a publicly available single-nucleus RNA sequencing dataset. Frozen NAc tissue from individuals with schizophrenia (n = 30) and controls (n = 30) were obtained from the New South Wales Brain Tissue Resource Centre. Protein levels of glutamate receptors, mGluR2, mGluR3, mGluR4, mGluR7, and a dopamine synthesis enzyme, tyrosine hydroxylase (TH) were quantified by western blot. mGluR transcripts were measured using qRT-PCR. Neuroinflammatory status was determined from levels of pro-inflammatory transcripts (SERPINA3, IL6, IL1β, and TNFα). TH protein levels were elevated in the NAc of individuals with schizophrenia. GRM1, GRM3, GRM4, GRM7 and GRM8 transcripts were strongly expressed in MSNs and inhibitory neurons. Gene and protein expression of the mGluRs did not differ between schizophrenia and controls. When the cohort was stratified into a high (n = 13) and a low (n = 42) inflammation group, GRM1 and GRM5 mRNAs were decreased in those with high inflammation. These data indicate that elevated inflammation, irrespective of schizophrenia diagnosis, is associated with a selective reduction of group I mGluR transcripts in the NAc. This suggests that inflammation may be a key modulator of glutamatergic signalling in this region. - Source: PubMed
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