UBP1 Antibody
- Known as:
- UBP1 Antibody
- Catalog number:
- 37699
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- UBP1 Antibody
Related genes to: UBP1 Antibody
- Gene:
- UBP1 NIH gene
- Name:
- upstream binding protein 1
- Previous symbol:
- -
- Synonyms:
- LBP-1a
- Chromosome:
- 3p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-05-13
- Date modifiied:
- 2017-08-04
Related products to: UBP1 Antibody
Related articles to: UBP1 Antibody
- Foxi1 is a master regulator of ionocytes (ISCs/INCs) across species and organs. Two subtypes of ISCs exist, and both α- and β-ISCs regulate pH- and ion-homeostasis in epithelia. Gain and loss of FOXI1 function are associated with human diseases, including Pendred syndrome, male infertility, renal acidosis, and cancers. Foxi1 was predominantly studied in the context of ISC specification, however, reports indicate additional functions in early and ectodermal development. Here, we re-investigated the functions of Foxi1 in Xenopus laevis embryonic mucociliary epidermis developpment and found a novel function for Foxi1 in the generation of Notch-ligand expressing mucociliary multipotent progenitors (MPPs). We demonstrate that MPPs are a distinct sub-population of epidermal cells in which Foxi1 has two concentration-dependent functions: At low levels, Foxi1 maintains ectodermal competence in MPPs through transcriptional and epigenetic mechanisms, while at high levels, Foxi1 induces a multi-step process of ISC specification and differentiation in cooperation with Ubp1 and Dmrt2. We further describe how foxi1 expression is affected through auto- and Notch-regulation, and how this developmental program affects mucociliary patterning. Together, we reveal novel functions for MPPs and Foxi1 in Xenopus mucociliary epidermis formation, relevant to our understanding of vertebrate development and human disease. - Source: PubMed
Publication date: 2026/01/05
Bowden SarahBrislinger-Engelhardt Magdalena MariaHansen MonaAndricek AishaTemporal-Plo AfricaWeber DamianHägele SandraLorenz FabianLitwin TimKreutz ClemensWalentek Peter - As an important tropical and subtropical fruit, litchi's inflorescence size and the number of florets per inflorescence are crucial factors affecting fruit set rate and yield. This study extensively collected a total of 219 litchi germplasm resources, including those from China and 11 other countries worldwide, systematically evaluating eight core phenotypic traits: inflorescence length (IL), inflorescence width (IW), number of secondary lateral inflorescences (NSLI), number of inflorescence internodes (NII), base to main axis length (BMAL), inverted 5th internode length (I5IL), number of female flowers per inflorescence (NFFI), and fertilization rate (FR). The research findings indicated significant correlations between these agronomic traits and fruit set rate, particularly with high fruit set rate litchi varieties showing notably lower trait expressions in IL, NSLI, NFFI, and NII compared to low fruit set rate varieties. Furthermore, through genome-wide association studies (GWAS), significant SNP loci were successfully identified for the two key traits, NSLI and NFFI, while other traits did not show significant associations. Transcriptome results revealed that differentially expressed genes between two typical inflorescence litchi varieties were mainly enriched in molecular function categories such as catalytic activity and transferase activity, affecting metabolic pathways and secondary metabolite synthesis. Joint analysis of GWAS and transcriptomics suggested that the NSLI-associated gene LITCHI016073 (UBP1-associated proteins) might regulate inflorescence development by influencing gibberellin signaling, while NFFI -associated genes LITCHI019855 (Solute carrier family), LITCHI011125 (SEC3A), LITCHI025977 (Acid phosphatase), and LITCHI023264 (Enolase) affected the development and number of female florets. The functions of these genes were further validated by transcriptome results. qRT-PCR analysis showed that in the Houxian variety (dense inflorescence), the expression levels of LITCHI016073, LITCHI011125, LITCHI025977, and LITCHI023264 during the three critical flowering stages were significantly higher than those in the Edanli variety, while the expression level of the LITCHI019855 gene was significantly lower, strongly demonstrating the important roles of these genes in inflorescence development and fruit set rate regulation. By employing large-scale sample analysis and multi-omics technologies, this study systematically unraveled the intrinsic relationships between litchi inflorescence traits and fruit set rate, providing a solid scientific basis and novel insights for litchi breeding practices. - Source: PubMed
Publication date: 2025/07/26
Shi FachaoHuang KanJiang YonghuaLiu HailunWen YingjieYan Qian - Upstream binding protein 1 (UBP1) is a transcription factor (TF) of the CP2/grainyhead family involved in various biological processes, including cancer cell proliferation, differentiation, and embryonic development. While other mammalian grainyhead-like TFs have been linked to different cancers, including breast cancer (BC), the role of UBP1 in BC remains unexplored. In this study, we provide a preliminary investigation into the novel functions of UBP1 in BC. Using online database screening, we first demonstrated that elevated UBP1 levels in breast carcinoma are associated with poor prognosis and adverse clinical outcomes. We further showed that UBP1 promotes epithelial-mesenchymal transition (EMT) and stemness in BC cells while regulating key signaling pathways, including the PI3K-Akt. Additionally, UBP1 modulates tumor metastasis by influencing tumor-associated macrophage (TAM) polarization, promoting an immunosuppressive macrophage phenotype, and driving tumor progression. Our findings highlight UBP1's pivotal role in BC progression through multiple mechanisms, including EMT induction, stemness maintenance, and macrophage polarization via activation of the NRG2/Akt axis. Moreover, higher UBP1 expression correlates with lower overall and recurrence-free survival, underscoring its potential as a prognostic marker and therapeutic target for aggressive BC. - Source: PubMed
Publication date: 2025/03/08
Jaiswal ApurvaNegi ManormaChoi Eun HaKaushik Nagendra KumarKaushik Neha - Stress granules (SGs) are transient, non-membrane-bound cytoplasmic condensates that form in response to environmental stresses, serving as protective reservoirs for mRNAs and proteins. In plants, SGs play a crucial role in stress adaptation, but their relationship with macroautophagy/autophagy, a key process for degrading damaged organelles and misfolded proteins, remains poorly understood. In a recent study, we revealed that key autophagy proteins, including components of the ATG1-ATG13 kinase complex, the class III phosphatidylinositol 3-kinase (PtdIns3K) complex, and the ATG8-PE system, translocate to SGs during heat stress (HS) in . Using biochemical, cell biological and genetic approaches, we demonstrated that ATG proteins accumulate on HS-induced SGs and are released to the cytosol upon SG disassembly during the post-HS recovery stage. This process facilitates rapid autophagy activation. Notably, a SG-deficient mutant () exhibits delayed autophagy activation and impaired clearance of ubiquitinated protein aggregates, highlighting the importance of SGs in regulating autophagy. Our findings uncover a novel mechanism by which SGs sequester autophagy proteins during stress, ensuring their rapid availability for stress recovery, and provide new insights into the interplay between SGs and autophagy in plant stress responses.: ATG, autophagy related; HS, heat stress; PtdIns3K, phosphatidylinositol 3-kinase; RBP47B, RNA-binding protein 47B; SG, stress granule; UBP1, ubiquitin-specific protease 1. - Source: PubMed
Publication date: 2025/02/19
Feng LeiLi XibaoShen WenjinGao Caiji - Proliferating cell nuclear antigen (PCNA) is essential for the faithful duplication of eukaryotic genomes. PCNA also orchestrates events necessary to address threats to genomic integrity, such as the DNA damage tolerance (DDT) response, a mechanism by which eukaryotic cells bypass replication-blocking lesions to maintain replisome stability. DDT is regulated by the ubiquitylation of PCNA and the consequent recruitment of specialized polymerases that ensure replication continuity. We have recently described that the deubiquitylases Ubp10 and Ubp12 modulate DDT events by reverting the ubiquitylation of PCNA in Saccharomyces cerevisiae. This study identifies Ubp1 as a novel PCNA deubiquitylase that cooperates with Ubp10 and Ubp12 in the regulation of DDT during DNA replication. Ubp1, previously known as a cytoplasmic protein, also localizes to the nucleus, where it associates with DNA replication forks. Additionally, Ubp1 interacts with and deubiquitylates PCNA. Here, we provide evidence that Ubp1 collaborates with Ubp10 and Ubp12 to facilitate DNA replication by efficiently reverting PCNAK164 ubiquitylation at replication forks under conditions free from exogenous perturbations. Consequently, the deletion of UBP1, UBP10, and UBP12 leads to persistent ubiquitylation of PCNAK164 and a marked delay in S phase progression. - Source: PubMed
Zamarreño JavierRodríguez SergioMuñoz SofíaBueno AvelinoSacristán María P