MAP2K3 & TAOK2 Protein Protein Interaction Antibody Pair
- Known as:
- MAP2K3 & TAOK2 Protein Protein Interaction Antibody Pair
- Catalog number:
- DI0513
- Product Quantity:
- 1 Set
- Category:
- -
- Supplier:
- Abno
- Gene target:
- MAP2K3 & TAOK2 Protein Interaction Antibody Pair
Related genes to: MAP2K3 & TAOK2 Protein Protein Interaction Antibody Pair
- Gene:
- MAP2K3 NIH gene
- Name:
- mitogen-activated protein kinase kinase 3
- Previous symbol:
- PRKMK3
- Synonyms:
- MEK3, MKK3, MAPKK3
- Chromosome:
- 17p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-11-11
- Date modifiied:
- 2016-10-05
- Gene:
- TAOK2 NIH gene
- Name:
- TAO kinase 2
- Previous symbol:
- -
- Synonyms:
- TAO1, KIAA0881, PSK, PSK1, TAO2, MAP3K17
- Chromosome:
- 16p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-10-20
- Date modifiied:
- 2015-08-26
Related products to: MAP2K3 & TAOK2 Protein Protein Interaction Antibody Pair
Related articles to: MAP2K3 & TAOK2 Protein Protein Interaction Antibody Pair
- Previous studies demonstrated that in vitro the protein kinase TAO2 activates MAP/ERK kinases (MEKs) 3, 4, and 6 toward their substrates p38 MAP kinase and c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK). In this study, we examined the ability of TAO2 to activate stress-sensitive MAP kinase pathways in cells and the relationship between activation of TAO2 and potential downstream pathways. Over-expression of TAO2 activated endogenous JNK/SAPK and p38 but not ERK1/2. Cotransfection experiments suggested that TAO2 selectively activates MEK3 and MEK6 but not MEKs 1, 4, or 7. Coimmunoprecipitation demonstrated that endogenous TAO2 specifically associates with MEK3 and MEK6 providing one mechanism for preferential recognition of MEKs upstream of p38. Sorbitol, and to a lesser extent, sodium chloride, Taxol, and nocodazole increased TAO2 activity toward itself and kinase-dead MEKs 3 and 6. Activation of endogenous TAO2 during differentiation of C2C12 myoblasts paralleled activation of p38 but not JNK/SAPK, consistent with the idea that TAO2 is a physiological regulator of p38 under certain circumstances. - Source: PubMed
Publication date: 2001/03/08
Chen ZCobb M H