BID & RHOA Protein Protein Interaction Antibody Pair
- Known as:
- BID & RHOA Protein Protein Interaction Antibody Pair
- Catalog number:
- DI0472
- Product Quantity:
- 1 Set
- Category:
- -
- Supplier:
- Abno
- Gene target:
- BID & RHOA Protein Interaction Antibody Pair
Related genes to: BID & RHOA Protein Protein Interaction Antibody Pair
- Gene:
- RHOA NIH gene
- Name:
- ras homolog family member A
- Previous symbol:
- ARH12, ARHA
- Synonyms:
- RhoA, Rho12, RHOH12
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1990-03-19
- Date modifiied:
- 2019-04-23
Related products to: BID & RHOA Protein Protein Interaction Antibody Pair
Related articles to: BID & RHOA Protein Protein Interaction Antibody Pair
- The ubiquitin ligase E6AP, encoded by the UBE3A gene, plays a prominent role in human papillomavirus (HPV)-induced cancers. In complex with the HPV E6 oncoprotein, it targets inter alia the tumor suppressor p53 for degradation, thereby contributing to cellular transformation. Besides affecting the substrate spectrum of E6AP, E6 acts as a potent activator of the catalytic activity of E6AP. Here we report that RhoA and its subfamily members RhoB and RhoC serve as substrates of the E6-E6AP complex, but more strikingly, also act as strong inhibitors of the complex. We show that RhoA subfamily members potently inhibit E6-E6AP-mediated ubiquitination and degradation of p53 and that this inhibitory effect is not due to simple substrate competition. In addition to establishing RhoA subfamily members as the first known cellular regulators of the E6-E6AP complex, we provide evidence that RhoA binds to E6AP in the absence of E6. Notably, loss of functional E6AP is the cause of Angelman syndrome (AS), a neurodevelopmental disorder, and RhoA plays a critical role in maintaining synaptic structure and function. Thus, we propose that the interaction of RhoA subfamily members with E6AP is of significance for the development of both HPV-induced cancers and AS. - Source: PubMed
Publication date: 2026/08/25
Eichbichler DanielaJansen JasminEulich NadjaStengel FlorianScheffner Martin - Limb frostbite caused by cold exposure is a prevalent injury in winter. However, effective therapies remain limited, particularly for cold-induced edema. This study evaluated the therapeutic potential of DangGuiSiNi Decoction (DSD), QiShenYiQi Pills (QSYQ), and their combination in a rat model of cold-induced limb injury. - Source: PubMed
Li HuanChen Fan-KaiLi An-QingWeng Ding-ZhouPan Chun-ShuiYan LiSun KaiLiu JianHan Jing-Yan - Cancer hotspot mutations of unknown function often obscure the functional understanding of the molecular pathways underlying cancer formation and limit precision medicine progress. Here, we investigated unresolved driver functions of RHOA in head and neck squamous cell carcinoma (HNSCC). Our investigation reveals that RHOA E40Q is a partial loss-of-function allele which paradoxically promotes tumorigenesis only in the absence of wild-type RhoA. Therefore, mice expressing RHOA E40Q specifically in keratinocytes lacking wild-type RhoA spontaneously developed squamous cell carcinoma and showed defective hair shaft formation. Mechanistically, this is related to increased replication stress and genome instability caused by aberrant expression of cell cycle regulators and DNA repair genes, independent of the classical RhoA effectors ROCK and DIAPH. These data establish RHOA E40Q as an unusual, context-dependent oncogenic driver: a seemingly inactive variant that unleashes its tumor-promoting potential only when the wild-type allele is absent. - Source: PubMed
Publication date: 2026/08/25
Noujarède JustineWang QiuyueKokkinogenis Eleftherios PanagiotisLuo YuewanCudina IvonaWillaume SimonMooser ClémenceNguyen Lap PhuocPoulsen Mads FrederikHeijmerikx SimonLe Phan Thu HanHe XiubinAndersen Jesper BøjeSørensen Claus StorgaardBrakebusch Cord - - Source: PubMed
Wang YifanShou ZhexingFan HengXu MengChen QianyunTang QingLiu XingxingWu HuiZhang ManYu TingDeng ShuangjiaoLiu Yujin - Retinitis pigmentosa (RP) is the most common inherited neurodegenerative retinal disease. Mer receptor tyrosine kinase (MERTK) mutations are associated with severe RP and dysfunction of the RPE. Previous studies have shown that MERTK and the Rho-associated coiled-coil-containing kinases (ROCK) pathway are involved in phagocytosis. However, the specific role of the ROCK pathway in the context of MERTK-associated RP needs to be revealed. - Source: PubMed
Publication date: 2026/08/11
Feng LujiaZhang TingDu YongQin YingyanZhou LinbinBai BingyuPeng ManjuanChen LuMa JinZhang Shaochong