APOH Antibody
- Known as:
- APOH Antibody
- Catalog number:
- 32237
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- APOH Antibody
Related genes to: APOH Antibody
- Gene:
- APOH NIH gene
- Name:
- apolipoprotein H
- Previous symbol:
- B2G1
- Synonyms:
- BG
- Chromosome:
- 17q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 1987-09-11
- Date modifiied:
- 2015-12-17
Related products to: APOH Antibody
Related articles to: APOH Antibody
- PEG-lipid interfaces influence LNP nano-bio interactions, yet conventional PEG-lipid formulations differ simultaneously in several molecular features that complicate attribution of ion-dependent effects. Here, using structurally defined DMA-PEG-OMe as a discrete PEG-lipid model and conventional DMA-PEG-OMe as a comparator, we show that Zn addition produces a concentration-dependent redistribution of organ-associated LNP-mediated mRNA expression from the liver toward the spleen. This redistribution was most pronounced in the PEG formulation and was not observed to the same extent in the conventional PEG formulation, supporting PEG-lipid interfacial architecture as an important determinant of the Zn-dependent response. Mechanistically, Zn is associated with protein-corona remodeling, including enrichment of apolipoprotein H (ApoH; β-glycoprotein I), a corona component previously linked to splenic tropism, together with reduced inflammatory transcriptional activation. In a prophylactic B16F10-OVA-luc challenge model, Zn@PEG-LNP treatment was associated with improved tumor control, higher total serum IgG and IgG1 signals, and stronger SIINFEKL-responsive CD8 T-cell responses. Together, these findings identify PEG-lipid interfacial architecture and Zn incorporation as a simple formulation strategy for spleen-directed mRNA delivery. - Source: PubMed
Publication date: 2026/09/21
Shao BingChen MinglongYou ChengyingZhang LinLiang TianzhuZhang GuoyingCen JieTan JiajiaLiu Shiyong - The immunosuppressive tumor microenvironment (TME) represents a major barrier to effective hepatocellular carcinoma (HCC) therapy. While interleukin-11 (IL-11) has been implicated in cancer progression, its immunomodulatory functions and underlying mechanisms in HCC remain poorly understood. - Source: PubMed
Publication date: 2026/09/17
Gao YangYao XijuanHuang XingWang LianWang YongZhu GuangyuWang ZhenLi LuGuo JinheLu Jian - Iodine-125 (I) seed therapy is recognized for treating abdominal solid tumors with minimal adjacent tissue damage but may induce radiation colitis when its implantation near colonic tissues, leading to a poor prognosis. Nevertheless, the underlying pathogenesis is not well understood. - Source: PubMed
Liu PingpingZeng XiongLiu WenjingXie HuichaoFang YongkunYang ErwanTang XiaoqiFan ChenglinChen Yihui - Acute liver failure (ALF) is a serious clinical disease. Immune infiltration and oxidative stress (OS) play an important role in ALF, but the combination of oxidative stress and immune infiltration in ALF has not been explored. - Source: PubMed
Publication date: 2026/09/09
Dai LuTan JungangZhou ZhiminChen ChengcongHu GuoxinGuo Ling - Anti-β2-glycoprotein I (anti-β2GPI) antibodies are central to antiphospholipid syndrome. The APOH locus has been associated with anti-β2GPI, but the causal variant and thrombotic risk implications remain unclear. - Source: PubMed
Publication date: 2026/09/07
Lalaurie ChristopheLiu LiliKhan AtlasWang ChenRich Stephen SBarr R GrahamBernstein Elana JKiryluk KrzysztofMcDonnell ThomasLuo Yiming