FCGR1A Antibody
- Known as:
- FCGR1A Antibody
- Catalog number:
- 32221
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- FCGR1A Antibody
Related genes to: FCGR1A Antibody
- Gene:
- FCGR1A NIH gene
- Name:
- Fc fragment of IgG receptor Ia
- Previous symbol:
- -
- Synonyms:
- CD64, CD64A
- Chromosome:
- 1q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-12-03
- Date modifiied:
- 2019-04-23
Related products to: FCGR1A Antibody
Related articles to: FCGR1A Antibody
- Standardized molecular methods to assess the host response to breast implants are lacking. Mass spectrometry-based proteomics offers an unbiased approach to characterize the capsule proteome and the foreign-body response. - Source: PubMed
Publication date: 2026/09/10
Larsen AndreasØstergaard OleWeltz Tim KongsmarkTran John Vinh QuangBak Erik Eiler FrydshouGuðjónsdóttir Linda RegínaHemmingsen Mathilde NejrupØrholt MathiasVester-Glowinski PeterWoetmann AndersOlsen Jesper VelgaardHerly Mikkel - Whole-blood gene expression has the potential to become an affordable alternative for the diagnosis of pulmonary tuberculosis (TB). Through an immune-based gene expression profile via the NanoString platform, we previously identified 12 genes from whole blood that distinguished active TB from other pulmonary diseases. Here, we performed a three-phase diagnostic test evaluation to determine the scientific validity and analytical and clinical performance of these 12 previously identified genes in accurately diagnosing active TB. We further employed binary classification machine learning models to assess and evaluate transcriptional signatures. Samples from 175 adults were included in the study. During phase one, we assessed the expression of 12 genes in 10 TB patients and 9 healthy controls. Elevated expression of FCGR1A, GBP5, PDCD1LG2, and IRAK3 was observed in TB patients compared with healthy controls (p value < 0.05). The analytical performance of these four genes was evaluated in a cohort of 100 symptomatic respiratory volunteers screened for TB, comprising 35 tuberculosis patients and 65 non-tuberculosis controls. The expression of FCGR1A, PDCD1LG2, and GBP5 consistently distinguished patients from both groups, with an area under the ROC curve (AUC) ≥ 0.75. These genes were combined into three transcriptional signatures (FCGB-2TB, FPG-3TB, and FCPD-2TB), which demonstrated good performance in a pilot clinical validation study phase (N = 56; sensitivity > 77%, specificity > 94%). The present analysis allowed the discovery of RT‒qPCR-based signatures for TB diagnosis. These signatures could serve as affordable alternatives for TB diagnosis at primary care centers. - Source: PubMed
Publication date: 2026/09/04
Horta ThaináHipólito CamillyAraújo Luana EPimentel CamilaSokolowskei DimitriCerqueira SilvaniaOliveira Flávia Marília FonsecaOliveira CarlosPetrilli JéssicaQueiroz AdrianoArruda Sérgio - The red-spotted grouper nervous necrosis virus (RGNNV) exhibits high pathogenicity in larval , yet the immune molecular mechanism remains unclear. Non-coding RNAs (ncRNAs) are vital in the host's immune responses during viral infection. However, there has been no study on ncRNA research for this species to date. We systematically identified 105 DE microRNAs (miRNAs), 157 DE long non-coding RNAs (lncRNAs) and 31 DE circular RNAs between the infection group and control group. Functional enrichment analysis revealed that these differentially expressed genes were significantly enriched in pathways associated with innate immune defense, inflammatory, and cell death, such as JAK-STAT signaling pathway, NF-κB signaling pathway, apoptosis, and necroptosis. Furthermore, the lncRNA-miRNA-mRNA interaction network involving miR-93 was constructed, which may represent a promising candidate therapy target for future investigations. This study presents the first comprehensive ncRNA transcriptome dataset of infected with RGNNV, identifies key antiviral defense and cell death-related genes and hub pathways, and thereby identifies miR-93-involved lncRNA-miRNA-mRNA network and key targeted genes () as hub molecular regulators in immune response of this species. - Source: PubMed
Publication date: 2026/08/12
Guo XiaoliGao ChengbinChen ZhangfanLu ShengWang LeiLi WenshengHe XinleiYang ChuanjunLi JianweiChen Songlin - Behçet's disease (BD) is a rare chronic systemic vasculitis of unknown etiology. The heterogeneity of peripheral blood immune cells and the dysregulation of intercellular communication in BD remain insufficiently characterized. The present study employs single-cell transcriptomics to comprehensively delineate the peripheral blood immune cell atlas of BD, identify candidate diagnostic biomarkers, and dissect the remodeling patterns of intercellular communication networks. - Source: PubMed
Publication date: 2026/08/04
Yang YanfeiChen Yuexin - Kawasaki disease (KD) is a multisystemic vasculitis of unknown aetiology in children. KD with coronary artery lesion (CAL) is now the leading acquired heart disease in children. Peripheral blood mononuclear cells (PBMCs) play roles in KD. We identified hub genes based on RNA sequencing data and validated them in PBMCs and human umbilical vein endothelial cells (HUVECs) co-culture with PBMCs. Expression profiling by high throughput sequencing (RNA-seq data) PBMCs from 12 acute KD patients and 12 healthy controls was performed to screen differentially expressed mRNAs (DE-mRNAs). We selected 20 KD with CAL, 20 KD patients without CAL and 40 healthy controls for validation, and established HUVECs co-culture with PBMCs. Real time-PCR was finally conducted to confirm the reliability and validity of the expression level of DE-mRNAs from PBMC-HUVECs co-cultures. A total of 6039 DE-mRNAs were found (2267 upregulated, 3772 downregulated). Thirty hub genes were selected. KD PBMCs significantly impaired HUVECs viability and migration. IL1R2 was downregulated, FCGR1A, and CD177 mRNAs were upregulated in acute KD and KD with CAL. IL1R2 was elevated, FCGR1A and CD177 mRNAs were downregulated in convalescence and KD without CAL. And the real-time PCR and ELISA results showed IL1R2 was downregulated in acute KD PBMC-HUVECs co-cultures and elevated in convalescence. These findings may improve our understanding of PBMCs and PBMC-HUVECs co-cultures with PBMCs in KD. - Source: PubMed
Publication date: 2026/06/30
Hong XiaofengWang QianwenLan TianXu JianxinZhan YiShi Jiandong