NFKBIA Antibody
- Known as:
- NFKBIA Antibody
- Catalog number:
- 32213
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- NFKBIA Antibody
Related genes to: NFKBIA Antibody
- Gene:
- NFKBIA NIH gene
- Name:
- NFKB inhibitor alpha
- Previous symbol:
- NFKBI
- Synonyms:
- IKBA, MAD-3, IkappaBalpha
- Chromosome:
- 14q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-02-13
- Date modifiied:
- 2019-04-23
Related products to: NFKBIA Antibody
Related articles to: NFKBIA Antibody
- Liver transplantation is the standard treatment for end-stage liver disease, but donor organ shortage has increased the use of marginal donor livers (eg, steatotic grafts). These livers are highly sensitive to liver ischemia/reperfusion injury (LIRI), worsening transplant outcomes, with unclear molecular mechanisms limiting targeted therapies. - Source: PubMed
Publication date: 2026/09/03
Lu KaiZhao Yi-MingChai Kui-YuanLyu YiZhang Xu-Feng - Glioma constitutes approximately 50% of primary brain tumors. This study aimed to analyze the mechanism by which TRIM38 contributes to the progression of glioma. - Source: PubMed
Yang PengxiangLi Huiyong - Glutaric acidemia type 1 (GA I) is caused by deficient activity of glutaryl-CoA dehydrogenase, leading to predominant accumulation of glutaric acid (GA) in the brain. GA I patients present progressive neurological deterioration whose pathophysiology is only partially elucidated. We investigated whether intracerebral GA administration, alone or combined with quinolinic acid (QA), a pro-inflammatory intermediate of the kynurenine pathway, could alter the expression of genes associated with inflammatory signaling, endoplasmic reticulum (ER) stress, and neurotrophic support in cerebral cortex of wild-type (WT) and Gcdh mice. We also tested the effects of L-carnitine (Carn) on these parameters. GA alone increased mRNA levels of the genes encoding NF-κB (NFKB1), COX-2 (PTGS2), iNOS (NOS2), and TLR2 (TLR2) in both genotypes, while reducing those of IL-10 (IL10) and VEGF-A (VEGFA) only in Gcdh mice. Combined QA + GA treatment produced a larger response, including increased TNF-α (TNF), IL-1β (IL1B), IL-6 (IL6), NLRP3 (NLRP3), CHOP (DDIT3) and PERK (EIF2AK3) mRNA levels in the Gcdh mice, besides reducing IκBα (NFKBIA), IL-10 (IL10) and BDNF (BDNF) expression in both genotypes, and VEGF-A (VEGFA) in the Gcdh mice. We also found that lysine (Lys) and QA treatment elevated TNF-α, IL-1β, and IL-6 protein levels in Gcdh mice. Carn prevented or attenuated most transcriptional alterations induced by QA + GA and reduced cytokine protein elevations elicited by Lys + QA administration. These findings indicate that Carn modulates acute molecular responses related to inflammation, ER stress, and neurotrophic factors in the cerebral cortex of the GAI mouse model. - Source: PubMed
Publication date: 2026/09/05
Castro Ediandra TissotZanatta ÂngelaCarvalho Andrey Vinicios Soaresde Moraes Amanda UggeriNetto Carlos AlexandreLeipnitz GuilhianAmaral Alexandre UmpierrezVargas Carmen ReglaRibeiro Rafael TeixeiraWajner Moacir - Declining laying performance and egg quality during the late laying period are closely associated with intestinal barrier dysfunction, chronic inflammation, and gut microbiota dysbiosis. In our previous study, dietary supplementation with 15 g/kg ultrafine powder (SMUP) exhibited the greatest improvement in laying performance and egg quality of hens during late laying period. However, the underlying mechanisms remain unclear. Therefore, the present study further investigate the effects of dietary SMUP on ileal morphology, barrier function, immune response, and gut microbiota, combined with analyses to elucidate the potential molecular mechanisms. - Source: PubMed
Publication date: 2026/08/20
Meng ChengwenAzad Md Abul KalamLin WenchaoGui JueCui YadongLan WeiKong Xiangfeng - Somatostatin receptor 2 is expressed in nasopharyngeal carcinoma (NPC). We report genomic and transcriptomic analysis results of 163 NPC cases, demonstrating that somatostatin receptor 2 (SSTR2) gene expression in EBV-positive and in EBV-negative NPC correlated with genomic alterations and an inflamed microenvironment. Median SSTR2 expression was 6.52 transcripts per million (TPM), ranging from 0.59 TPM (Quartile 1 [Q1], 18.2% EBV-positive) to 35.79 TPM (Q4, 82.9% EBV-positive). PIK3CA (20.51%) and CYLD (10.53%)/NFKBIA (12.82%) mutations were enriched in SSTR2-Q1 versus -Q4. Tumor mutation burden was negatively correlated (R = -0.27, p < 0.001) with SSTR2, while PD-L1 tumor proportion score (2% vs. 92.5% [SSTR2:Q1 vs. Q4], p < 0.001) and T-cell inflamed score correlated with SSTR2 expression (R = 0.53, p < 0.001). B-cells, M1 macrophages, CD8+ T-cells, Treg cells, and dendritic cells were enriched in SSTR2-Q4, while neutrophils were prominent in SSTR2-Q1. These results demonstrate a significant positive correlation between SSTR2 expression and an inflamed tumor microenvironment in NPC. This suggests that SSTR2 expression in NPC may be a clinically useful biomarker, correlating with the tumor microenvironment (including, potentially, sensitivity to immunotherapy) and its genetic profile. - Source: PubMed
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