SERPINB5 Antibody
- Known as:
- SERPINB5 Antibody
- Catalog number:
- 32208
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- SERPINB5 Antibody
Related genes to: SERPINB5 Antibody
- Gene:
- SERPINB5 NIH gene
- Name:
- serpin family B member 5
- Previous symbol:
- PI5
- Synonyms:
- maspin
- Chromosome:
- 18q21.33
- Locus Type:
- gene with protein product
- Date approved:
- 1994-06-20
- Date modifiied:
- 2016-04-06
Related products to: SERPINB5 Antibody
Related articles to: SERPINB5 Antibody
- To identify the key molecular target and elucidate the underlying mechanism by which the histone deacetylase inhibitor trichostatin A (TSA) treats ulcerative colitis (UC). - Source: PubMed
Publication date: 2026/09/09
Gao JinlongLai XiangyuHe MeipingShi Rong - Maspin regulates cellular adhesion, migration, apoptosis, angiogenesis, and tumor suppression in a tissue and context-dependent manner. Its functional diversity is governed largely thorough extracellular matrix interactions, subcellular localization, and the reactive center loop (RCL), although the structural details are not well understood. To examine whether alternative splicing contributes to this heterogeneity, we analysed the SERPINB5 gene using a computational genomics approach and identified a novel 80 bp coding exon upstream of the first coding exon (E1). The alternatively spliced transcript was validated in human skin and esophagus by semi-nested touchdown PCR, quantitative real-time PCR, and Sanger sequencing. Recombinant B5N displayed a red-shifted fluorescence emission spectrum, indicating a more solvent-exposed conformation, which was supported by molecular dynamics simulations showing greater exposure of the nuclear localization signal (NLS) and the reactive center loop. Enzyme kinetic assays demonstrated concentration-dependent enhancement of tissue plasminogen activator (tPA) activity by both isoforms. In HaCaT cells, wildtype maspin produced stronger antiproliferative and anti-migratory effects, whereas B5N was only mildly antiproliferative. Annexin V/7-AAD staining revealed that wildtype maspin induced higher early apoptosis and cell death, while B5N produced lower overall cell death but a greater proportion of late apoptotic cells. RNA-seq of transfected HaCaT cells identified differentially expressed genes enriched in inflammatory, antiviral, and apoptotic pathways, which was validated by qPCR, and several of these were markedly upregulated in SARS-CoV-2 infected A549 cells. Thus, a novel N-terminally extended maspin isoform with differentially regulated gene profile is identified and validated in this study. - Source: PubMed
Publication date: 2026/09/12
Gupta SwatiFatima SanaAnsari Mohd ZamaAslam LubnaAhmad TanveerJairajpuri Mohamad Aman - Emphysema is a well-recognized risk factor for lung cancer; however, its influence on the immunologic tumor microenvironment in lung adenocarcinoma remains poorly defined. In this pilot, hypothesis-generating study, immune-related gene expression profiling was performed using archival formalin-fixed paraffin-embedded tumor specimens from 12 patients with lung adenocarcinoma, including the Never-smoker group (never-smokers without emphysema; = 4), the Smoker 1 group (smokers without emphysema; = 3), and the Smoker 2 group (smokers with CT-defined emphysema; = 5). Expression of 770 immune-related genes was analyzed using the nCounter PanCancer IO 360 Panel (NanoString Technologies, Seattle, WA, USA). Compared with the Never-smoker group, tumors from the Smoker 1 group showed marked upregulation of SFRP1, SERPINB5, and IL6, whereas tumors from the Smoker 2 group exhibited increased expression of KIR2DL3, BLK, and WNT2B. Relative to the Smoker 1 group, the Smoker 2 group demonstrated significant upregulation of MMP7, TDO2, and CCL18. Pathway enrichment analysis revealed cytokine-cytokine receptor interaction as the most prominently enriched pathway in both smoker groups, while the IL-17 signaling pathway was preferentially enriched in the Smoker 2 group. In addition, diffusing capacity for carbon monoxide showed significant correlations with immune-related genes including IL-6 and IL-6R. Collectively, these preliminary findings suggest that lung adenocarcinoma arising in emphysematous lungs may be characterized by a distinct pro-inflammatory immune microenvironment. Given the small sample size and potential confounders, these results should be regarded as hypothesis-generating. Emphysema-associated immune remodeling may nevertheless represent an important biological factor worthy of validation in larger, independent cohorts. - Source: PubMed
Publication date: 2026/04/29
Lim Jeong UkKim SeohyeonAn Tai JoonSa Young JoKim Hyo RimPark Chan KwonYoon Hyoung KyuKim Tae-Jung - - Source: PubMed
Pu TianFeng RanranWang ChunruZhao Ye - Invasive lobular carcinoma (ILC) accounts for 15% of breast cancers and presents challenges such as chemotherapy resistance and poorer survival outcomes compared to other subtypes. While often managed similarly to invasive ductal carcinoma (IDC), ILC requires tailored approaches due to its distinct biology. Ferroptosis, an iron-dependent form of cell death, shows potential in overcoming therapeutic resistance but remains unexplored in ILC. This study aimed to identify ferroptosis-related molecular subtypes, develop a robust gene signature using machine learning, construct an integrated prognostic model, and uncover potential therapeutic targets for ILC. - Source: PubMed
Publication date: 2026/02/25
Liu JunjieLi XiaoqianLi ZiyanZhang RuiLi XiaoduoFeng KexuanZhang WeiHe JianjunZhang Huimin