NCF2 Antibody
- Known as:
- NCF2 Antibody
- Catalog number:
- 32207
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- NCF2 Antibody
Related genes to: NCF2 Antibody
- Gene:
- NCF2 NIH gene
- Name:
- neutrophil cytosolic factor 2
- Previous symbol:
- -
- Synonyms:
- p67phox, NOXA2
- Chromosome:
- 1q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-05-25
- Date modifiied:
- 2019-04-23
Related products to: NCF2 Antibody
Related articles to: NCF2 Antibody
- Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease of the upper airway driven by diverse inflammatory cells and mediators. This study aimed to characterize the inflammatory landscape of CRSwNP and to identify and validate oxidative stress-related key genes in CRSwNP. - Source: PubMed
Publication date: 2026/08/26
Gu YuelongTang RuLiu ZhihanZhou JiayaoZhu YingMao SongLi ZhipengZhang WeitianLin Hai - Oxidative stress induced by inhaled oxidants, particularly cigarette smoke, contributes to the development of several acute and chronic respiratory diseases through oxidative damage and epigenetic alterations. Curcumin (CUR), a well-characterized natural polyphenol with potent antioxidant and anti-inflammatory properties, is considered a promising agent for modulating oxidative stress-related signaling pathways and epigenetic mechanisms; however, its poor aqueous solubility and bioavailability limit its clinical application. Therefore, in the present study, PEGylated curcumin (PEG-CUR) was investigated as a modified CUR formulation for subsequent incorporation into a dissolving microneedle-based intranasal delivery system. Exposure to cigarette smoke condensate (CSC) resulted in significant alterations in the expression of oxidative stress-related genes (SEPP1, NCF2, SFTPD, CCL5, and PTGS1) in nasal epithelial cells. However, pretreatment with CUR and PEG-CUR mitigated these gene expression changes. Both treatments also reduced global DNA methylation, with PEG-CUR showing a more pronounced effect than CUR. Following the demonstration of the beneficial effects of PEG-CUR, we developed PEG-CUR-loaded dissolving microneedle patches (PEG-CUR-DMNPs) as a localized intranasal delivery platform designed to facilitate PEG-CUR delivery through rapid dissolution of the microneedle tips. The mechanical robustness and penetration capability of the patches were initially evaluated using Parafilm® and ex vivo rat dorsal skin models. To further confirm their appropriateness for intranasal use, PEG-CUR-DMNPs were subsequently tested on ex vivo sheep nasal mucosa to evaluate microneedle penetration and dissolution kinetics. Overall, these results indicate that PEG-CUR-DMNPs represent a promising approach for localized intranasal drug delivery targeting oxidative stress-related respiratory diseases. - Source: PubMed
Publication date: 2026/09/05
Kilic BusraAkel Bilgic HayriyeUnal Bugra KaganMerdivenli OnurUzun CengizCakmak SonerAydin Halil MuratKaraaslan Cagatay - Hepatocellular carcinoma is a malignant tumor that ranks sixth in incidence and third in mortality globally. In this study, based on the principles of chemical splicing and prodrug synthesis strategies, a total of 26 new derivatives, including 17 cinnamic acid derivatives, 8 quinoline derivatives, and 1 triazole derivative, were designed and synthesized using terrein (1), isolated from the endophytic fungus Aspergillus terreus of Sphagneticola trilobata as the parent compound. Among these, the IC values for the proliferation-inhibitory effects of the cinnamic acid derivative 1i and the quinoline derivative 2a on liver cancer cells Hep G2 were 0.8 and 4.6 μM, respectively, which were 120 and 21-fold stronger than those of 1. In addition, 1i and 2a exhibited proliferation inhibition rates against Hep G2 cells were observed to be lower by factors of 14.4 and 9.65, respectively, compared to those against AML-12 cells, demonstrating that moderate selectivity and a certain therapeutic window are exhibited by these compounds. Molecular mechanism studies have shown that both 1i and 2a could induce apoptosis in Hep G2 cells by inhibiting the PI3K/Akt signaling pathway, arresting the cell cycle, and suppressing cell proliferation and migration. The difference is that 1i arrested the cell cycle in the S phase, while 2a arrested it in the G0/G1 phase. Further transcriptomic analysis, combined with molecular docking and isothermal titration calorimetry results, indicated that the likely target of 1i was NCF2, while the target of 2a was WNT9A. In vivo studies further confirmed that 1i demonstrated superior anti-tumor activity and safety compared to positive control Sorafenib. Overall, the findings of this study indicate that derivatives 1i and 2a are highly promising candidate drugs for the treatment of hepatocellular carcinoma. - Source: PubMed
Publication date: 2026/08/27
Li WenxingYi GuohuiHuang DanHui YangChen Wenhao - Mepolizumab, an anti-IL5 monoclonal antibody, effectively reduces exacerbations and improves disease control in severe eosinophilic asthma (SEA). While this treatment rapidly decreases blood eosinophil counts, some patients continue to experience asthma symptoms, suggesting that other features beyond eosinophil number contribute to disease persistence. In this work, we aim to characterize the molecular and functional signature of circulating eosinophils in SEA in response to mepolizumab therapy. - Source: PubMed
Publication date: 2026/08/26
Miguéns-Suárez PabloVázquez-Mera SaraMartelo-Vidal LauraAparicio Marina BlancoÁlvarez Uxío CalvoFernández Coral GonzálezAñón Mar MosteiroAbelaira Dolores CorbachoValverde Tamara HermidaHenríquez Christian CalvoBravo Susana BUller LenaNieto-Fontarigo Juan JSalgado Francisco JGonzález-Barcala Francisco J - This study describes a reproducible computational workflow for identifying endoplasmic reticulum stress (ERS)-related gene signatures in atrial fibrillation (AF) by integrating bulk transcriptomics, machine learning, immune infiltration analysis, and single-cell transcriptomics. Public bulk transcriptomic datasets were retrieved from the Gene Expression Omnibus (GEO), followed by phenotype harmonization, normalization, batch-effect correction, and differential expression analysis. Weighted gene co-expression network analysis (WGCNA) was combined with ERS-related gene sets to identify candidate ERS-associated genes. A multi-algorithm machine-learning framework was then used to compare feature-selection and model-fitting strategies. The selected model was evaluated in an independent external validation cohort (GSE115574) and further assessed in an additional cohort (GSE14975), with discriminatory performance quantified by receiver operating characteristic (ROC) analysis and the area under the curve (AUC). Using this workflow, 22 ERS-related core genes were identified, and an 18-gene Elastic Net (Enet) model showed the highest overall discriminatory performance across the training and validation cohorts. SHapley Additive exPlanations (SHAP) analysis highlighted the major contribution of genes such as RPS11, NCF2, and S100A4 to model prediction. Immune deconvolution and single-cell transcriptomic analysis further mapped the ERS-related signature predominantly to the monocyte-macrophage lineage, suggesting its potential involvement in AF-associated immune remodeling. This workflow provides a reproducible strategy for linking disease-associated transcriptomic signatures to specific immune cell populations and can be adapted to other disease contexts with suitable bulk and single-cell datasets. - Source: PubMed
Publication date: 2026/08/07
Li QingruiTeng FeiJi XiangyuXuan YuanxinTong SiyuBai FangfangWang Pengrui