BAG1 Antibody
- Known as:
- BAG1 Antibody
- Catalog number:
- 32161
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- BAG1 Antibody
Related genes to: BAG1 Antibody
- Gene:
- BAG1 NIH gene
- Name:
- BCL2 associated athanogene 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 9p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-06-19
- Date modifiied:
- 2016-10-05
Related products to: BAG1 Antibody
Related articles to: BAG1 Antibody
- Heat shock proteins of the HSP70 family and their BAG co-chaperones regulate responses to oxidative stress, inflammation, apoptosis, and ischemia, all central to coronary artery disease (CAD) pathogenesis. The contribution of genetic variants within HSP70-family and BAG co-chaperone genes to CAD susceptibility remains unclear. Thus, we sought to evaluate associations of HSP70- and BAG-related SNPs with CAD risk and to characterize their potential regulatory effects using comprehensive bioinformatic analyses. A case-control cohort of 834 CAD patients and 1328 controls of Russian ethnicity was genotyped for 13 SNPs. Associations with CAD susceptibility and traits were tested using log-additive regression with adaptive permutation. Loci underwent functional annotation. The C allele of BAG1 rs706121 was associated with increased CAD risk overall (OR = 1.24, p = 0.019), in males (OR = 1.39, p = 0.002), and in smokers (OR = 1.39, p = 0.020). BAG3 rs196329 was associated with lower risk in males (A allele: OR = 0.82, p = 0.040), whereas HSPA6 rs753856 was associated with reduced risk in physically active individuals (G allele: OR = 0.61, p = 0.008). Additional associations involved clinical or biochemical traits. Functional annotation identified potential regulatory effects, including eQTL associations, overlap with histone marks, and allele-dependent changes in transcription factor binding. HSP70 and BAG variants may contribute to CAD susceptibility and support sex- and lifestyle-informed risk assessment. - Source: PubMed
Publication date: 2026/08/15
Polshvedkina OlgaKobzeva KseniaOrlov Yuriy LBushueva Olga - In immunocompromised individuals, infection can disseminate rapidly, causing severe cerebral and visceral complications. This study aimed to synthesize gold nanoparticles (AuNPs) via green synthesis and evaluate their therapeutic efficacy and mechanisms in immunosuppressed murine models of toxoplasmosis. - Source: PubMed
Masoori LeilaKhazaal Ruaa MajidRashidipour MarziehSepahvand MaryamMahmoudvand Hossein - This investigation was conducted to assess the effects and potential mechanisms of action of phellandrene (PR) and pyrimethamine (PYM) combination therapy in the context of chronic cerebral toxoplasmosis in immunocompromised (ICM) murine models. - Source: PubMed
Publication date: 2026/07/30
Alasmari Saeed M NAlatawi Aishah - Endocrine therapy (ET) selection in estrogen receptor-positive breast cancer (ER + BC) is guided by menopausal status and tolerability rather than tumor biology, despite substantial heterogeneity in recurrence. We hypothesized that baseline gene expression differentially associates with recurrence depending on initial ET class. In a retrospective cohort of 74 ER+/HER2- patients treated with adjuvant ET, we profiled baseline tumor RNA and fitted adjusted Cox models for gene and ET interactions on time-to-recurrence and time-to-switch. Among selective estrogen receptor modulators-initiated patients, higher expression of , , , , and was associated with markedly increased recurrence, while no comparable association was observed among aromatase inhibitors-initiated patients. Forty-one percent of patients switched ET at least once, predominantly due to intolerance (joint pain, unspecified side effects); switching was not consistently associated with tumor biology. These hypothesis-generating findings identify candidate gene and ET interactions and motivate validation in larger, independent cohorts. - Source: PubMed
Publication date: 2026/06/30
Jones VeronicaWang YongzheQuinones ChristineAljaber DanaNelson EvaNath AritroKang IreneRugo HopeYee LisaSeewaldt VictoriaMortimer Joanne - The purpose of this study was to evaluate the effect of bioactive glasses containing a small proportion of fluoride and zinc in lower (BAG1) and higher ratios (BAG2) on the Vickers microhardness (VHN), surface morphology and chemical composition of high-viscosity glass ionomer cement and glass hybrid cement. - Source: PubMed
Šošić AntonelaŠalinović IvanMiletić IvanaSauro SalvatoreKekez IvanaIvanišević Ana