TYMP Antibody
- Known as:
- TYMP Antibody
- Catalog number:
- 32154
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- TYMP Antibody
Related genes to: TYMP Antibody
- Gene:
- TYMP NIH gene
- Name:
- thymidine phosphorylase
- Previous symbol:
- MNGIE, ECGF1
- Synonyms:
- -
- Chromosome:
- 22q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1991-06-27
- Date modifiied:
- 2019-04-23
Related products to: TYMP Antibody
Related articles to: TYMP Antibody
- Cellular heterogeneity in sepsis complicates the identification of cell-specific therapeutic targets. We aimed to identify genetically supported candidate immunogenetic regulators associated with sepsis through integrative multi-omics analyses. - Source: PubMed
Publication date: 2026/09/22
Wang YananZhao JianglinZhang YushiShen JiShi YuanLiu QingxiangZhang Xuefeng - Intracellular nucleotide imbalance between ribonucleotides and deoxyribonucleotides can trigger cytosolic mitochondrial DNA (mtDNA) release and subsequent activation of the cGAS-STING pathway. However, fluoropyrimidine-induced nucleotide imbalance is constrained by their metabolic instability. Here, we leverage ribonucleotides to amplify floxuridine (FUDR)-induced mtDNA release and cGAS-STING activation for enhanced cancer chemoimmunotherapy. We identified that cytidine monophosphate (CMP) significantly enhances FUDR-mediated activation of the mtDNA-driven cGAS-STING pathway, inducing over 300-fold upregulation of the interferon gene Ifnb1 and initiating STING-dependent antitumor immunity. Genome-wide CRISPR-Cas9 screening identified five pyrimidine-metabolizing enzymes (CMPK1, CMPK2, TYMP, UPP1, and UPP2) that are responsible for the metabolic instability of floxuridine monophosphate (FdUMP). CMP and its intracellular metabolites can metabolically block these enzymes, thereby increasing the peak intracellular concentration of FdUMP by over 500-fold and extending its half-life by more than 20-fold, which in turn promotes sustained intracellular nucleotide imbalance. To translate this mechanism into therapy, we co-encapsulated FdUMP and CMP into hybrid lipid nanoparticles (FC-NPs). FC-NPs robustly activated STING-dependent antitumor immunity, achieving remarkable therapeutic efficacy in multiple murine colorectal cancer (CRC) models. Our study not only addresses the long-standing issue of fluoropyrimidine metabolic instability but also reveals a novel ribonucleotide-mediated immunomodulatory mechanism, providing a promising strategy to potentiate chemoimmunotherapy in CRC. - Source: PubMed
Publication date: 2026/09/21
Wang ChaoZhao ChenxuanYao YesongZou ZhiwenShi AnxinFeng ZhuoYang MingkangYu YueLiu YangRui XuehuiWu Jinhui - This study systematically explored immune targets in gastric adenocarcinoma (GAC) suitable for mRNA vaccine development. Based on multi-omics data from public databases, we first screened a set of potential tumor-associated antigen genes. Subsequently, using ten machine learning algorithms, we constructed 101 prognostic models and, through optimization and comparison, selected the Random Survival Forest (RSF) method to establish a clinical prognostic model for GAC consisting of seven genes (TYMP, IFGN, ITGAX, GBP5, GBP4, STAT1, CD84). At both the genetic and protein levels, these genes were closely associated with the antigen presentation process, suggesting the potential functional role of this model in antigen presentation. Further analysis of the immune infiltration characteristics in GAC preliminarily revealed its possible immune evasion mechanisms. Building on this, we designed candidate mRNA vaccine templates for GAC using the mRNAdesigner platform. Additionally, this study investigated the potential roles of the above seven genes in GAC progression and screened small-molecule compounds targeting these genes. Molecular dynamics simulations (MD) were performed to verify the binding stability between these compounds and their corresponding proteins. This study comprehensively simulated the tumor microenvironment (TME) and antigen presentation process in GAC, evaluated the clinical translation potential of the neoantigen prognostic model and its predictive value for immunotherapy, and provided a preliminary design scheme for an mRNA vaccine against GAC. The findings offer new evidence for identifying immune therapy targets in GAC and are expected to advance the development of immunotherapy strategies for GAC. - Source: PubMed
Publication date: 2026/08/28
Liang JiaxiangXie ZhipengSun YingjieTang YuhengGul SaminaQi QiPang JianyuChen YongzhiWang HuiZhang JiehuiTang WenruZhou Xuhong - Cervical cancer (CC) affects women worldwide, and more than 95% of cases are caused by persistent infection with high-risk human papillomavirus (HR-HPV), such as type 16, which promotes the progression of precancerous lesions to cancer. This study aimed to identify differentially expressed proteins (DEPs) in biopsies from patients with HPV16+ low-grade squamous intraepithelial lesions (LSILs) and from patients with HPV16+ squamous cell carcinoma (SCC) compared with those from HPV-negative normal cervical tissue (NCT HPV-) controls. The samples were analyzed by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) using a data-independent acquisition (DIA) approach. Data processing and differential protein expression analysis were performed with the DIA-NN software (Data-Independent Acquisition Neural Networks), followed by bioinformatics analyses, including Venn diagrams, pathway enrichment, functional interactome, The Cancer Genome Atlas (TCGA)-SCC data integration, and Western blot detection. In total, 1607 DEPs associated with cell adhesion and extracellular matrix proteins were identified in LSILs, whereas 1516 DEPs associated with catalytic and transport activities were identified in SCC; the proteins overexpressed in LSILs (332) were enriched in processes such as metabolism, immune response activation, and stress and cell death responses. In contrast, proteins overexpressed in SCC (205) were associated with the cell cycle, DNA damage, drug metabolism, proteasome degradation, methylation, and immune response. Interaction analyses highlighted proteins related to early proteins 1,5,6 and 7 (E1, E5, E6, and E7). In terms of the two DEPs, S100 calcium binding protein A10 (S100A10/p11) and thymidine phosphorylase (TYMP) were detected in patients with LSIL, HSIL, and SCC at the protein level, consistent with their higher transcript levels in public datasets. Given the small, exploratory cohort, these findings are hypothesis-generating, and validation in a larger, balanced, independent cohort is required. In conclusion, this study identified DEPs associated with the progression of premalignant lesions to SCC that may represent candidate biomarkers and therapeutic targets warranting further investigation. - Source: PubMed
Publication date: 2026/07/26
Gonzalez-Tolentino Diana LauraGaribay-Cerdenares Olga LiliaEncarnación-Guevara SergioMartínez-Batallar Ángel GabrielAlonso-Bastida RamiroGil JeovanisOrganista-Nava JorgeAlarcón-Romero Luz Del CarmenLeyva-Vázquez Marco AntonioIllades-Aguiar Berenice - : B-cell acute lymphoblastic leukemia (B-ALL) is the most frequent malignancy of childhood; worldwide, 487,294 new cases and 305,405 deaths were reported in 2022, including more than 5000 new cases in Mexico. Chemotherapy, delivered in induction, consolidation and maintenance phases, remains the mainstay of treatment, yet 10-20% of patients relapse after induction because of chemoresistance, whose molecular basis is still incompletely understood. : This retrospective study aimed to identify proteins associated with resistance to vincristine (VCR) and methotrexate (MTX) administered during the induction phase, using LC-MS/MS proteomics and bioinformatic analysis of treatment-naive bone marrow aspirates from responders and nonresponders. : Nonresponders showed a distinct proteomic profile, with deregulated processes converging on cytoskeletal structure and dynamics, nucleic acid metabolism, DNA repair and RNA processing. Within these processes, thymidine phosphorylase (TYMP) and gelsolin (GSN) emerged as differentially expressed proteins, both consistently overexpressed in nonresponders at the individual-patient level. : We conclude that cytoskeletal remodeling and nucleotide metabolism are prominent features of intrinsic chemoresistance in pediatric B-ALL, and that TYMP and GSN represent candidate biomarkers of nonresponse to VCR- and MTX-based induction that warrant validation by orthogonal methods in independent, adequately powered cohorts. - Source: PubMed
Publication date: 2026/07/26
Flores-Palma Esli JanaiGonzalez-Tolentino Diana LauraEncarnación-Guevara SergioGil JeovanisAlonso-Bastida RamiroMartínez-Batallar Angel GabrielSaavedra-Herrera Mónica VirginiaIbarra-Sierra EloísaGómez-Gómez YazmínIllades-Aguiar BereniceGaribay-Cerdenares Olga LiliaLeyva-Vázquez Marco Antonio