RARA Antibody
- Known as:
- RARA Antibody
- Catalog number:
- 32074
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- RARA Antibody
Related genes to: RARA Antibody
- Gene:
- RARA NIH gene
- Name:
- retinoic acid receptor alpha
- Previous symbol:
- -
- Synonyms:
- RAR, NR1B1
- Chromosome:
- 17q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1988-06-09
- Date modifiied:
- 2019-04-23
Related products to: RARA Antibody
Related articles to: RARA Antibody
- Acute promyelocytic leukemia (APL) is a hematologic emergency in which prompt diagnosis is essential to reduce early hemorrhagic mortality. Although oral manifestations are well recognized in acute myeloid leukemia, gingival infiltration is distinctly uncommon in APL, and concomitant central nervous system (CNS) involvement at presentation is exceptionally rare. As gingival lesions may be sampled during their diagnostic evaluation, recognition of characteristic cytomorphology on fine-needle aspiration cytology (FNAC) can provide an early clue to the underlying hematologic malignancy. - Source: PubMed
Publication date: 2026/10/03
Radhakrishnan AravindAdhikari KaustabhSharma PraveenMallik NabhajitJain ArihantGupta Parikshaa - A 69-year-old man with acute promyelocytic leukemia in molecular remission and no detectable PML::RARA transcripts in his peripheral blood cells developed acute otitis media. After 10 months, tympanomastoidectomy was performed for suspected secondary cholesteatoma. A histological examination confirmed extramedullary relapse with PML::RARA-positive cell infiltration. The patient achieved a second molecular remission after treatment with arsenic trioxide. Our findings suggest that (1) a diagnostic sample may be obtained from mastoid air cells rather than from the middle ear cavity, (2) molecular remission does not preclude extramedullary relapse, and (3) all-trans retinoic acid and arsenic trioxide combination therapy may reduce the risk of extramedullary relapse. - Source: PubMed
Publication date: 2026/09/29
Tsuge NorikoKobayashi TaisukeKomori MasahiroMurakami IchiroNegishi TatsuyaShigeto ShoheiTsunaga YutaOhara KeitoWatanabe ShinichiroYoshida ShoheiKojima Kensuke - Acute promyelocytic leukemia (APL) is a hematologic emergency characterized by a high risk of coagulopathy that can manifest with both severe bleeding and thrombotic events, including ischemic stroke. However, its initial presentation as large vessel arterial thrombosis is infrequent and potentially lethal. We report the case of a previously healthy 15-year-old female referred for suspected left frontal ischemic stroke with right spastic hemiplegia and expressive aphasia. One week earlier, she had presented with headache, nausea and transient episodes of paresthesias and weakness of the right hand and foot. Laboratory studies revealed bicytopenia (leukopenia and anemia), hypofibrinogenemia and elevated D-dimer. Imaging studies showed a subacute infarct in the left caudate nucleus and recent ischemia in the frontal cortex with complete occlusion of the left internal carotid artery. Bone marrow aspirate showed blast cells with Auer rods and strong positivity for myeloperoxidase. Flow cytometry revealed 41,2 % of cells with a phenotype compatible with promyelocytes, PML::RARA fusión gene was confirmed by molecular and cytogenetic studies. Immediate treatment with all-trans retinoic acid (ATRA), corticosteroids, and hemostatic support was initiated. Subsequently, the patient presented with a new occipital infarction and was started on anticoagulant therapy. She did well with motor and speech recovery. This case highlights the importance of considering APL as an underlying etiology of arterial thrombotic events in adolescents with cytopenias and coagulopathy, especially in the presence of major vessel occlusion, where early diagnosis and timely treatment are essential to reduce morbidity and mortality. - Source: PubMed
Publication date: 2026/08/24
Tarchini MalenaHerrera Andino María LauraHollmann Carlos HernanLópez Orozco MilagrosMás María EmiliaLlorens AldanaBrochero NatachaRivoire Juan ManuelArgüello Zamarbide María LourdesAballay Andrea MilagrosRicchi Brenda NidiaFiora María BelénSalazar Florencia CelesteColussi Yuliana SofíaEckhardt Andrea AlejandraSaad Emanuel José - Acute myeloid leukemia (AML) is characterized by high genotypic and immunophenotypic heterogeneity. We collected an extensive dataset containing 5366 flow cytometry files from 885 AML patients, stained with the EuroFlow acute leukemia orientation tube (ALOT) and AML/MDS panel, acquired in a standardized way at eight centers over a period of 10 years. Unsupervised clustering identified groups of patients based on FlowSOM-derived cell population percentages. In addition, we investigated immunophenotypic patterns in World Health Organization (WHO) patient classes and NPM1 subclasses, both at the cell population and the individual marker level. Some WHO classes, for example, AML with t(8;21)(q22;q22)/RUNX1::RUNX1T1 or t(15;17)(q24;q21)/PML::RARA, showed homogeneous immunophenotypes. Characterization of maturation arrest using FlowSOM confirmed maturation arrest at early stages in distinct WHO classes. Finally, a machine learning model was trained to predict WHO genetic classes from immunophenotypic data. The model allowed accurate prediction in 77% of cases, reproducible in an independent validation cohort. In conclusion, we show that EuroFlow standardized protocols allow analysis of multi-centric data measured over an extended period of time. Computational analysis demonstrated inter- and intrapatient immunophenotypic heterogeneity and allowed prediction of genetic abnormalities. - Source: PubMed
Publication date: 2026/09/29
Bonte SarahOlsman RosanVan Gassen SofieMatarraz SergioVillamor NeusNierkens StefanFernandez Paulada Costa Elaine SobralAanei Carmen-MarianaOrfao Albertovan Dongen Jacques J MSaeys YvanHofmans Mattiasvan der Velden Vincent H J - - Source: PubMed
Publication date: 2026/09/22
Wu Hsin ChiehLaplantine EmmanuelEsnault CécileNiwa-Kawakita MichikoZhang YiDe Almeida Bastos VivianeGeoffroy Marie-Claudede Thé Hugues