CDKN1B Antibody
- Known as:
- CDKN1B Antibody
- Catalog number:
- 32066
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- CDKN1B Antibody
Related genes to: CDKN1B Antibody
- Gene:
- CDKN1B NIH gene
- Name:
- cyclin dependent kinase inhibitor 1B
- Previous symbol:
- -
- Synonyms:
- KIP1, P27KIP1
- Chromosome:
- 12p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1995-09-14
- Date modifiied:
- 2016-10-05
Related products to: CDKN1B Antibody
Related articles to: CDKN1B Antibody
- Palbociclib has shown survival benefits in hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer. At present, however, no genetic predictors of palbociclib-related hematological toxicity have been validated for clinical use. The aim of this study was to evaluate whether genetic variants are associated with palbociclib toxicity and patient prognosis. Multicenter study of 113 patients with HR-positive, HER2-negative locally advanced or metastatic breast cancer treated with palbociclib plus endocrine therapy. Genotyping of DNA from blood samples was performed to determine 18 variants in seven target genes (, , , , , , and ). Association analyses were performed to assess the relationship between the genetic variants and treatment-related toxicity and survival outcomes. Sixty-seven patients (59.3%) developed grade 3/4 neutropenia, 62 (54.9%) experienced disease progression, and 43 (38.1%) died. Although none of the univariate associations remained significant after Bonferroni correction, the multivariate analysis, adjusted for clinical variables, revealed several nominally significant associations. The gene variants rs6785049 ( = 0.01) and rs3732360 ( = 0.009) were associated with grade 3/4 neutropenia. The rs6785049 variant was associated with palbociclib treatment interruption ( = 0.03) and with worse progression-free ( = 0.003) and overall survival ( = 0.02). The findings of this exploratory study suggest potential associations between the rs6785049 variant and treatment toxicity and survival outcomes in patients with HR-positive, HER2-negative locally advanced or metastatic breast cancer treated with palbociclib. However, these hypothesis-generating findings need to be independently validated. - Source: PubMed
Publication date: 2026/09/18
Arqueros CristinaAndrés MartaServitja SòniaGiner JúliaTibau AriadnaBorrell MariaMartinez-Recio SergioBarnadas AgustíSalazar Juliana - Breast cancer progression is associated with dysregulation of cell survival, apoptosis, and cell-cycle control. Oleuropein (OL), a major secoiridoid constituent of olive-derived products, has attracted interest because of its diverse biological activities and potential relevance to cancer research. This study evaluated the cellular and molecular responses to OL in MDA-MB-231 triple-negative breast cancer cells and non-malignant human umbilical vein endothelial cells (HUVECs). Cell viability was assessed following exposure to 10-250 µg/mL OL for 24, 48, and 72 h. OL produced an exposure-time-dependent reduction in MDA-MB-231 cell viability, with estimated IC₅₀ values of >250 µg/mL at 24 h, 117.5 µg/mL at 48 h, and 26.42 µg/mL at 72 h. Based on the overall viability profiles of the two cell models, 100 µg/mL OL was selected for subsequent functional and molecular analyses. At this concentration, MDA-MB-231 viability progressively decreased with prolonged exposure, whereas HUVEC MTT-derived viability values were maintained. OL treatment reduced clonogenic capacity and wound closure in MDA-MB-231 cells, while increased clonogenic capacity and wound closure were observed in HUVECs. qRT-PCR analysis showed increased BAX and CDKN1B and reduced BCL2 expression in MDA-MB-231 cells, whereas HUVECs exhibited reduced BAX and increased BCL2 and CDKN1B expression. Western blot analysis revealed time-dependent changes in BAX, BCL-2, and p27 protein abundance, with partial directional correspondence to the transcriptional findings, particularly at later exposure times. Collectively, these findings indicate that OL elicits distinct cell type-dependent responses in malignant breast cancer and non-malignant endothelial cells. The coordinated viability, clonogenic, wound closure, and molecular expression profiles observed in MDA-MB-231 cells support further investigation of OL in breast cancer models, while the distinct HUVEC response highlights the need to clarify its endothelial and angiogenesis-related effects. - Source: PubMed
Publication date: 2026/09/25
Okuyan DeryaAvcıkurt Ayla Solmaz - To investigate the role of histone lactylation in chronic constriction injury (CCI)-induced neuropathic pain and elucidate its mechanism. - Source: PubMed
Ou Xiao-JingZhu Feng-TingZhang Man-YanLi LangZhao Wei-ChengWen Xian-Jie - In regenerative species, such as teleost fish, Müller glia (MG) autonomously re-enter the cell cycle after injury and give rise to functional retinal neurons. In contrast, the loss of retinal neurons in mammals is irreversible due to the limited proliferative and regenerative ability of MG. Various strategies have been developed to induce proliferation of mature mouse MG with or without injury, yet most MG daughter cells retain glial cell fate. Here, we found that MG progenies maintain high Notch signaling, which may constrain their neurogenic potential. Conditional deletion of , the central transcriptional effector of Notch, induced limited MG-to-neuron conversion in mature MG without proliferation. However, deletion, combined with forced MG proliferation by overexpressing and suppressing , significantly promoted MG dedifferentiation and ectopic expression of the neuronal marker Otx2 in MG daughter cells in uninjured mouse retina. Combining Notch inhibition with MG cell cycle re-activation not only increased the numbers of bipolar- and amacrine-like cells generated from MG but also promoted the further differentiation toward ON-cone, OFF-cone, and rod-bipolar subtypes. Single-nucleus RNA and ATAC sequencing data revealed that Notch inhibition facilitated the formation of MG-derived progenitor-like cells while MG proliferation increased chromatin accessibility of neurogenic genes. Notably, most MG-derived cells survived long term despite incomplete maturation. Together, our findings delineate how Notch inhibition and MG proliferation, alone or in combination, influence the regenerative potential of MG in the mammalian retina. - Source: PubMed
Publication date: 2026/09/17
Liao BaoshanLyu ChengshangJiang YuqingLiu ShanggongWong WaihoZhang JiadongTsang HoyinXie JunxiChen LingxiZhang QinrongXiong Wenjun - A combination of endogenous hypercortisolism and primary hyperparathyroidism (PHPT) occurs rarely, few clinical cases are described in the literature. The causes of the development of such combination are poorly investigated. - Source: PubMed
Publication date: 2026/09/08
Mamedova E OPrzhiyalkovskaya E GRozhinskaya L YaYanar E AChugunov I SKolodkina A AVasilyev E VTiulpakov A NBelaya Zh EMelnichenko G A