SIRT2 Antibody
- Known as:
- SIRT2 Antibody
- Catalog number:
- 32057
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- SIRT2 Antibody
Related genes to: SIRT2 Antibody
- Gene:
- SIRT2 NIH gene
- Name:
- sirtuin 2
- Previous symbol:
- SIR2L
- Synonyms:
- -
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-10-14
- Date modifiied:
- 2016-10-05
Related products to: SIRT2 Antibody
Related articles to: SIRT2 Antibody
- To evaluate morphologic and quantitative MRI features associated with seromucinous and mucinous ovarian tumors of benign and borderline histology, with emphasis on their complementary role within structured preoperative imaging assessment. - Source: PubMed
Publication date: 2026/09/18
Özyılmaz SafaKulalı Fatma - Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of hepatocellular carcinoma (HCC), but how metabolic zonation drives regional transformation remains unclear. We identify sirtuin 2 (SIRT2) as a zonated cholesterol sensor that initiates reprogramming to drive MASLD-HCC. Lineage tracing establishes zone 1 hepatocytes as the cellular origin of tumors. SIRT2 overexpression in zone 1 triggers HCC, whereas its deletion prevents carcinogenesis by restoring cholesterol and bile acid metabolism and CD8 T cell recruitment. Mechanistically, cholesterol binds and activates SIRT2, which deacetylates sterol carrier protein 2 (SCP2) at Lys546, thereby blocking peroxisome proliferator-activated receptor α (PPARα) recruitment to the Cyp7b1 promoter, suppressing alternative bile acid synthesis, and permitting 27-hydroxycholesterol accumulation. SIRT2 inhibition reverses this cascade in mice and human hepatic organoids. Patient specimens confirm zonal SIRT2 and cytochrome P450 7B1 (CYP7B1) dysregulation. Our findings establish spatially compartmentalized cholesterol sensing as a new regulatory layer and identify SIRT2 as a druggable target in liver cancer. - Source: PubMed
Publication date: 2026/09/17
Zhang YingtingLong XidaiFu YinkunTang XinxinLuo HaoZou ZhihuiHe WeiHan LongchuanLi YueLuo JingTian LihongLu YuhengChen YiPan RimingBao XinyuLuo YuruiHuang ZonglinZhang ZhenwuLiu YonghuiFeng LiHuang YingLin Chao-PoZhang JianChen GuoqiangHe Ming - Aspirin, as the most widely used drug in the world, has been reported to exert antiplatelet, anti-inflammatory, and anti-tumor effects. However, apart from the hydrolyzed acetyl group acetylating proteins, and salicylic acid functioning as a classic COX enzyme inhibitor, it is unknown whether the salicylic group of aspirin could participate in the salicylation of histone lysine. Herein, we discover and characterize lysine salicylation (Ksa) in histone and 39 Ksa sites of histone were mapped in 3 cell lines. Ksa could be stimulated by aspirin via direct action and conversion to salicyl-CoA, and regulated by CBP and SIRT2 in vivo. Multi-omics analyses reveal associations between histone Ksa enrichment and transcriptional changes in physiologically relevant genes. Moreover, immunohistochemistry of Ksa levels in bladder cancer tissues are associated with aspirin exposure and show a preliminary correlation with recurrence-related outcomes. Collectively, we discover a new histone mark with potential physiological relevance and may reveal a previously unrecognized mechanism underlying the non-canonical functions of aspirin. - Source: PubMed
Publication date: 2026/09/16
Zhang FacaiZhou ChuanzanHe JiaoyanHuang PengpengZhang RongHu HuanJiao MengHu LinyiLiu FengQi XiaolongHe XiangYang YunkaiChinn Y EugeneFeng DechaoZhang DahongZhang Qi - Along with being a significant disease in dairy cattle which incurs economic loss, mastitis also affects a wide range of parameters that involve milk yield and quality. However, the role of long non-coding RNAs (lncRNAs) in the regulation of mastitis in distinct stages of the disease in Sahiwal cows is yet to be understood. This study characterised lncRNA expression profiles and competing endogenous RNA (ceRNA) networks across healthy, subclinical, and clinical mastitis stages using RNA-Seq data from milk somatic cells. Five biologically relevant ceRNA modules were identified: Five ceRNA modules were identified that are biologically relevant: MSTRG.21615.2, is predicted to sponge bta-miR-760-3p and bta-miR-212, and involved in co-regulation of OAT and SIRT2, leading to dysregulation of urea-cycle and NAD ⁺ -metabolism; MSTRG.19791.1-bta-miR-2382-5p, which activates an extracellular antioxidant network (SOD3, CAT, GPX family, PARK7); MSTRG.1150.15-bta-miR-92b, which regulates the PTEN/PI3K-AKT signalling axis; MSTRG.19363.1-bta-miR-1296, involved in the nuclear import machinery (KPNA7, RCC1, RANBP1, NUP50), with reduced expression in clinical versus subclinical mastitis; and MSTRG.25768.1-bta-miR-2425-5p, linked to extracellular matrix remodelling via the ADAMTS. The binding prediction of all six lncRNA-miRNA pairs were favourable, with the highest predicted affinity observed for MSTRG.1150.15-bta-miR-92b (-15.4 ± 6.9 kcal/mol) and moderate but biologically relevant binding for MSTRG.19363.1-bta-miR-1296 (-7.8 ± 4.2 kcal/mol). Molecular dynamics over 50 ns revealed that the MSTRG.19363.1-bta-miR-1296 complex was the most stable, exhibiting lowest RMSD and radius of gyration values, suggesting that it may be a viable regulator of nuclear transport during the progression of mastitis. These results shed light on the underlying mechanisms of lncRNA-regulated networks associated with dairy cattle mastitis. - Source: PubMed
Publication date: 2026/09/15
Pandey BharatiTyagi Chetna - The clinical efficacy of osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), in EGFR-mutant non-small cell lung cancer (NSCLC) is limited by the inevitable acquired resistance. Drug-tolerant persister (DTP) cells, which survive initial therapy, are considered a key reservoir for this resistance. Understanding the molecular characteristics of DTPs is essential for developing strategies to prevent relapse. - Source: PubMed
Publication date: 2026/09/15
Han JuneKyuJung EuitaekShin Soon Young