FABP4 Antibody
- Known as:
- FABP4 Antibody
- Catalog number:
- 32030
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- FABP4 Antibody
Related genes to: FABP4 Antibody
- Gene:
- FABP4 NIH gene
- Name:
- fatty acid binding protein 4
- Previous symbol:
- -
- Synonyms:
- A-FABP, aP2
- Chromosome:
- 8q21.13
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-06
- Date modifiied:
- 2016-01-18
Related products to: FABP4 Antibody
Related articles to: FABP4 Antibody
- Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal, with a 5‑year survival of only 13%. Its aggressive biology and late diagnosis often lead to metastatic spread at presentations. This review examines how metabolic reprogramming regulates angiogenesis in PDAC and explores the therapeutic implications of this coupling. We systematically analyzed published studies on glucose, amino acid, and lipid metabolic alterations and their interconnection with neovascularization through hypoxia-inducible factor-1α (HIF-1α), oncogenic signaling, and metabolite-mediated pathways. Based on a synthesis of the current literature, metabolic-angiogenic coupling appears to operate through at least three interconnected mechanisms: the HIF‑1α/pyruvate kinase M2 (PKM2)-driven glycolytic-vascular endothelial growth factor (VEGF) axis; lactate acting as a signaling molecule that promotes M2‑polarized tumor‑associated macrophages and stabilizes HIF‑1α; and lipid metabolites--including eicosanoids and fatty acid‑binding protein 4 (FABP4)-that modulate endothelial function and survival. In addition, glutamine-derived intermediates support endothelial sprouting and extracellular matrix remodeling, while tryptophan and serine pathways influence the immune-angiogenic balance. Importantly, compensatory pathways (e.g., HIF-1α-independent angiogenesis via glycogen accumulation and protease-activated receptor‑2 activation) limit the efficacy of single‑agent interventions, highlighting the need for combination strategies. Understanding these metabolic-angiogenic networks provides a rationale for biomarker‑guided therapies that simultaneously target tumor metabolism and vascularization. Integrating metabolic and angiogenic biomarkers (e.g., VEGF, lactate dehydrogenase A) with imaging-based metabolic profiling may improve patient stratification and treatment monitoring in PDAC. - Source: PubMed
Publication date: 2026/10/01
Ye XinWang ZihanWang Ping - Reproductive efficiency in yaks is limited by the poor developmental competence of their oocytes during in vitro maturation (IVM). Magnolol (MAG), a natural polyphenolic compound with potent antioxidant activity, has been reported to regulate cellular metabolism and oxidative stress; however, its role in oocyte maturation and early embryonic development remains unclear. Therefore, this study investigated the effects and molecular mechanisms of MAG on yak oocyte maturation and developmental competence. - Source: PubMed
Publication date: 2026/10/02
Zuo QiyongZhang HuiZhong DonglanLi TianhaoLiao YuejiaoPan YangyangWang LibinYu SijiuCui Yan - Limosilactobacillus fermentum is a promising probiotic species with reported benefits for gastrointestinal health and host metabolism. In this study, a novel L. fermentum strain, DX2034, isolated from the feces of a healthy Korean infant, was characterized through phenotypic and genomic analyses, and its anti-adipogenic activity was evaluated in differentiated 3T3-L1 adipocytes. DX2034 exhibited high tolerance to simulated gastric and bile conditions and showed stronger adhesion to Caco-2 cells than the reference strain L. fermentum CECT5716. The strain showed no hemolytic activity and was susceptible to most tested antibiotics. Whole-genome sequencing revealed a single circular chromosome of 2 160 171 bp with no acquired antibiotic resistance genes, virulence-associated factors, or concerning secondary metabolite biosynthetic gene clusters. Comparative genomic analysis identified genomic regions showing low similarity to reference strains, including a putative glycosyltransferase-associated locus, and genes associated with stress adaptation, gastrointestinal persistence, surface modification, and quorum sensing. Heat-killed DX2034 significantly reduced lipid accumulation, intracellular triglyceride content, and expression of adipogenesis-related genes, including C/EBPα, PPARγ, FABP4, LPL, and FASN. These effects were attenuated by the TLR2 inhibitor C29, suggesting involvement of TLR2-associated signaling. Collectively, DX2034 exhibits favorable probiotic-associated characteristics, genomic safety, and TLR2-associated anti-adipogenic activity, supporting its potential as a functional probiotic or postbiotic candidate. - Source: PubMed
Publication date: 2026/09/30
Park Do-WonKim Ji HyungPark Do-Young - Paris polyphylla Smith var. yunnanensis (Franch.) Hand.-Mazz., a traditional heat-clearing and detoxifying Chinese herb, has been extensively used in cancer therapy as a key constituent of Chinese patent medicines. Although the antitumor activities of individual steroidal saponin monomers have been extensively investigated, the therapeutic potential and molecular targets of the total saponins from Paris polyphylla var. yunnanensis (TPP) in breast cancer have not yet been reported. - Source: PubMed
Publication date: 2026/09/29
Huang Hua-TingZhou Li-PengChen QiWang Wen-QiYao Shu-ChangZhang Hua-JuanLi Ya-XuanQu Chang-HaiYin Xing-BinNi JianDong Xiao-Xv - Fatty infiltration of the supraspinatus muscle following rotator cuff tear (RCT) is a major pathological factor leading to poor functional outcomes, yet effective treatments are lacking. The kinase mammalian Sterile 20-like kinase 1 (MST1) has been implicated in metabolic disorders, but its role in RCT-associated muscle steatosis remains unexplored. - Source: PubMed
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