MAPK3 Antibody
- Known as:
- MAPK3 Antibody
- Catalog number:
- 32027
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- MAPK3 Antibody
Related genes to: MAPK3 Antibody
- Gene:
- MAPK3 NIH gene
- Name:
- mitogen-activated protein kinase 3
- Previous symbol:
- PRKM3
- Synonyms:
- ERK1, p44mapk, p44erk1
- Chromosome:
- 16p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-05
- Date modifiied:
- 2015-09-03
Related products to: MAPK3 Antibody
Related articles to: MAPK3 Antibody
- Emamectin benzoate (EMB) is a highly effective and widely detected environmental insecticide whose potential to induce severe cardiotoxicity and localized myocardial inflammation has raised substantial biomedical concerns. Quercetin (Que), a ubiquitous plant-derived natural antioxidant, has shown promise in mitigating exogenous chemical-induced toxicities, yet its precise immunopharmacological mechanism against EMB-induced cardiotoxicity remains to be fully elucidated. This study investigated the protective effects and mechanisms of Que. against EMB-induced cardiotoxicity by integrating network toxicology, transcriptomics, and in vivo/in vitro experimental validation. Multi-omics analysis identified MAPK8, MAPK3, and CASP3 as key responsive targets conserved across species. Functional enrichment revealed that these targets are predominantly involved in the MAPK/NF-κB signaling pathway and mitochondrial organization. Molecular docking and targeted intervention experiments confirmed that Que. potentially targets and binds to JNK (encoded by MAPK8), thereby blocking the EMB-activated signaling axis. This molecular interaction effectively restored mitochondrial dynamics and prevented mitochondrial DNA leakage into the cytoplasm, ultimately alleviating myocardial PANoptosis. Collectively, our findings demonstrate that Que. serves as a natural antagonist against chemical-induced cardiotoxicity by modulating the MAPK/NF-κB axis, offering a promising therapeutic strategy for mitigating pesticide-related immunotoxicological risks. - Source: PubMed
Publication date: 2026/09/05
Liu YongHe BaiLi LiWang ChunhuaZhang LipingMu QingchunCai De - Neutrophil extracellular traps (NETs) participate in thrombosis, inflammation, and cardiovascular remodeling, yet whether NET-related genes (NRGs) are associated with atrial fibrillation (AF) risk across multiple molecular layers remains unclear. This study used a multiomics Mendelian randomization framework to prioritize NRGs supported by methylation, expression, and protein quantitative trait loci (QTL) data. - Source: PubMed
Publication date: 2026/08/21
Zhou RuyaZhang PengzhaoZhu FeiyuLian TingtingWu Xianjun - Systemic lupus erythematosus (SLE) is a chronic autoimmune condition characterized by immunological dysregulation, inflammation, and oxidative stress, affecting multiple organs. The need for safer therapeutic alternatives is highlighted by the substantial side effects and inconsistent effectiveness of current treatments. The current study employed integrated computational and experimental methods to examine the potential effects of β-sitosterol against pristane induced SLE. - Source: PubMed
Publication date: 2026/08/31
Gibo RikngamChetia PurbajitKom George HmangteTalukdar Apurba - Considering that periodontitis is a chronic immunoinflammatory disease, the use of agents to modulate the host response has been investigated. Lycopene is a carotenoid hydrocarbon that exerts anti-inflammatory and antioxidant effects. This study aimed to evaluate whether the systemic lycopene administration reduces the harmful effects of induced periodontitis in rat molars. 108 male Holtzman rats were distributed into 3 groups: Control group (CG), Periodontitis group (PG), and Periodontitis group treated daily with 20 mg/kg of lycopene (PLG). Periodontitis was induced by ligature placement on the first upper molars. After 7, 35, and 70 days following periodontitis induction and lycopene treatment, the rats were anaesthetised and blood was collected to measure serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Maxillary and liver fragments were processed for morphological analysis, while gingival samples were collected to evaluate the gene expression of Il1b, Tnf, Tnfsf11, Tnfrsf11b, Mmp9, Nfkb1, and Mapk3 by RT-qPCR. Statistical differences were evaluated using a two-way ANOVA followed by Tukey's post-test, with significance level set at p < 0.05. Serum AST was significantly higher in PG samples than CG at all time points, and significantly lower in PLG than in PG at 35 and 70 days. In contrast, serum ALT concentrations showed no significant differences among groups or over time. No hepatic morphological changes were observed in the HE-stained sections in any of the groups. PLG specimens showed lower Tnf, Nfkb1, and Mapk3 mRNA levels at all time points and reduced Il1b expression at days 7 and 35, compared to the PG. Additionally, compared to the PG group, PLG specimens exhibited significantly reduced bone loss, junctional epithelium migration, inflammatory infiltrate in the gingiva, osteoclast counts, and RANKL/OPG ratio, alongside lower MMP-9 and cathepsin K immunoexpression in osteoclasts. These results demonstrated that lycopene mitigates periodontitis by reducing inflammation and attenuating alveolar bone loss via suppression of osteoclastogenesis and resorptive enzymes, representing a promising therapeutic agent. - Source: PubMed
Publication date: 2026/08/29
Silva Arles Naisa Amaralde Oliveira Gabriellade Andrade Rodrigues LucasMingatto Maria Eduarda FernandesGouvea Lays CristinaSasso-Cerri EstelaCerri Paulo Sérgio - circRNA plays a key regulatory role in various human tumors. This study was carried out to investigate the molecular mechanism of circBIRC6 in regulating cisplatin (DDP) resistance in choroidal melanoma. - Source: PubMed
Publication date: 2026/08/28
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