MMP9 Antibody
- Known as:
- MMP9 Antibody
- Catalog number:
- 29091
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- MMP9 Antibody
Related genes to: MMP9 Antibody
- Gene:
- MMP9 NIH gene
- Name:
- matrix metallopeptidase 9
- Previous symbol:
- CLG4B
- Synonyms:
- -
- Chromosome:
- 20q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1990-03-14
- Date modifiied:
- 2015-02-23
Related products to: MMP9 Antibody
Related articles to: MMP9 Antibody
- This study aimed to identify bioactive constituents of Jingtong Granules (JTG), a traditional Chinese medicine for cervical spondylotic radiculopathy (CSR), characterize their in vivo exposure, and explore pharmacological targets and pathways. Chemical constituents were characterized by LC-MS with GNPS-based molecular networking, and key compounds were prioritized via molecular docking; pharmacokinetic analysis was characterized in vivo exposure, and anti-inflammatory activity was evaluated via NO production in LPS-stimulated BV2 cells. Network pharmacology with GO and KEGG enrichment identified potential targets and pathways. Seventy-three components were identified in vitro and 10 in vivo. Albiflorin, puerarin, and ginsenoside Rg1 were rapidly absorbed and reduced NO production dose-dependently. Network analysis suggested MMP9 and PTGS2 as key targets, involving TNF and PI3K-AKT signaling pathways. JTG and its exposed constituents exert anti-inflammatory effects by modulating inflammatory targets and pathways. Albiflorin, puerarin, and ginsenoside Rg1 are prioritized as candidate bioactive constituents; MMP9, PTGS2, TNF, and PI3K-AKT pathways are putative mechanistic nodes requiring further validation. - Source: PubMed
Liu JieLi RenhuQiu JunjieLi ChenDou XixiCheng HeliJiang YujuanWang BingCui YueChen YongXu Tengfei - Oral squamous cell carcinoma (OSCC) remains an important cause of cancer morbidity and mortality, and new multi-target approaches are required to increase therapeutic options. Drug repurposing offers a promising strategy to identify new anticancer applications for clinically approved drugs with established safety profiles. An integrative in silico workflow was designed to identify overlapping targets between selected antifungal drugs and OSCC-associated genes based on network pharmacology and protein-protein interaction analysis. Network pharmacology identified 144 common targets for antifungals and OSCC, and EGFR and MMP9 were selected as druggable hubs based on their contributions to cancer progression. Molecular Docking revealed promising binding, with fluconazole (-8.5 kcal/mol) and itraconazole (-8.2 kcal/mol) showing better binding than the reference inhibitors tanomastat (-8.3) and erlotinib (-6.9) against MMP9 and EGFR, respectively. However, 200 ns molecular dynamics simulations and MM-PBSA calculations showed a different reality. Erlotinib and tanomastat showed the dynamic signature of specific binding, including persistent hydrogen bonds, restricted PCA clusters, and deep free energy minima. In contrast, fluconazole-EGFR showed thermodynamically unfavorable binding (+20.249 kJ/mol), fluconazole-MMP9 showed transient contacts mediated through zinc, and itraconazole-EGFR did not form persistent hydrogen bonds. Notably, the highest RMSD (0.31 ± 0.11 nm), protein destabilisation and unreliable binding energy (±101.005 kJ/mol) were shown by itraconazole-MMP9. The results imply that fluconazole and itraconazole are not specific and direct inhibitors of EGFR or MMP9, and their docking scores are artifacts from zinc chelation and hydrophobic overestimation. This study provides a cautionary computational framework emphasizing that rigorous MD and MM-PBSA validation is indispensable for reliable drug repurposing. - Source: PubMed
Publication date: 2026/07/14
Mayadevi Nair AnjuRao Bounika EsvanthAnand Kumar Abhi VenkatshreeKondaveeti Satish SrinivasRamanathan GnanasambandamRamshankar VijayalakshmiCatakapatri Venugopal Divyambika - Matrix metalloproteinases (MMP-9) play a vital role in extracellular matrix remodeling in metabolic-associated steatotic liver disease (MASLD) and cardiovascular diseases such as atherosclerosis. This study assesses MMP-9 levels in conjunction with non-invasive scoring systems (BAAT, BARD, FIB-4, NAFLD Fibrosis Score, and the ALT/AST ratio) aiming to enhance early diagnosis and disease monitoring. - Source: PubMed
Publication date: 2026/06/23
Salum Ghada MAbd El Meguid MaiFotouh Basma EMokhles MohamedSiddik Reham IbrahimElwan Sherif HassanSaleh AhmedDawood Reham M - Intracerebral hemorrhage (ICH) induces severe neurological injury, and the glymphatic system plays a critical role in post-ICH brain recovery. This study investigated the role of neural precursor cell expressed developmentally down-regulated protein 4 (NEDD4), an E3 ubiquitin ligase, in modulating glymphatic function and neuroprotection after ICH. - Source: PubMed
Publication date: 2026/09/16
Tan CongZheng XiaobinPeng LiChen WeimingWang ChuangHan JiangliGao Ling - Vaccines delivered via the nasal route have attracted increasing attention for their capacity to engage the mucosal immune system at the primary site of pathogen entry. However, the early innate mechanisms that shape local immune responses following nasal immunisation remain poorly defined. Here, we identified previously uncharacterised tissue-derived mediators induced during vaccination. Using an intranasally administered whole-cell pertussis (wP) vaccine that recapitulates key features of Bordetella pertussis infection and elicits long-lasting immunity, we show that nasal delivery triggers neutrophil recruitment along with a marked upregulation of secretory leukocyte protease inhibitor (SLPI). Employing SLPI- and neutrophil-deficient mouse models, we demonstrate that SLPI and neutrophils influence the production of key mediators associated with coagulation (PAI-1) and tissue remodelling (MMP-3 and MMP-9) within the airway. Notably, neutrophils also modulate early local total IgA release. Together, these findings suggest a coordinated and context-dependent interplay between cellular and soluble innate components that shape early mucosal immune responses. Furthermore, identified mediators may represent candidate biomarkers in the development of intranasal vaccines against B. pertussis and other pathogens. - Source: PubMed
Osiecka OktawiaTyshchenko MariiaSinkevich IvanPocałuń NataliaCichy JoannaKwiecinski Jakub MOleszycka EwaWilk Mieszko M