MMP9 Antibody
- Known as:
- MMP9 Antibody
- Catalog number:
- 29091
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- MMP9 Antibody
Related genes to: MMP9 Antibody
- Gene:
- MMP9 NIH gene
- Name:
- matrix metallopeptidase 9
- Previous symbol:
- CLG4B
- Synonyms:
- -
- Chromosome:
- 20q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1990-03-14
- Date modifiied:
- 2015-02-23
Related products to: MMP9 Antibody
Related articles to: MMP9 Antibody
- Gastric cancer (GC) remains a leading cause of cancer-related mortality, with progression driven largely by the tumor microenvironment (TME). Tumor-associated macrophages (TAMs), the most abundant immune cells in the GC stroma, drive immune evasion, angiogenesis, metastasis, and chemoresistance through polarization toward an M2-like phenotype. - Source: PubMed
Publication date: 2026/08/20
Zhuang XiaodongYang QiangHuang LiangjiuLiu RishengMa TingGuan LiwenZheng Yana - Rosacea is a chronic inflammatory skin disorder with limited therapeutic options. Puhuaiyin (PHY), a traditional Chinese medicinal formula, shows clinical efficacy, but its multi-component mechanisms remain unclear. - Source: PubMed
Publication date: 2026/08/21
Sun DanYang NanaZhao YidingLi WenbinLiu JingZeng WeihuiLi Youbao - Disseminated acanthamoebiasis is a rare but severe opportunistic infection that can involve multiple organs, including the liver, causing fatal outcomes. This study provides new insights into hepatic pathogenesis and possible relationship with angiogenesis activity and the therapeutic role of quercetin conjugated silver nanoparticles (Q-AgNPs). Sixty BALB/c mice were divided into four groups: uninfected control, uninfected treated with Q-AgNPs, infected group and infected treated with Q-AgNPs. The Q-AgNPs were synthesised and characterised by spectrophotometry, electron microscope, zeta potential and dynamic light scattering. Hepatic tissues were examined histopathologically for granulomas (classified as caseating/non-caseating and immature/mature) and vascular changes. Hypoglycaemia and expression of angiogenic markers (CD31, CD34 and MMP9) were assessed. Acanthamoeba polyphaga infection induced significant hepatic granulomatous inflammation, hypoglycaemia, vascular remodelling and upregulation of CD31, CD34 and MMP9, indicating active angiogenesis. Granulomas exhibited necrotic cores in some cases and progressed from immature to mature stages. Q-AgNPs treatment markedly attenuated granuloma numbers, suppressing angiogenic marker expression, mitigating inflammation, capillary permeability and liver lesions. This study provides novel evidence linking Acanthamoeba infection to hepatic granuloma formation and angiogenesis-driven pathology which may serve as useful biomarkers for extracerebral acanthamoebiasis. Further studies are needed to evaluate long-term outcomes and host-parasite interaction. - Source: PubMed
Fadladdin Yousef Abdal JalilAbdel-Samiee Mahmoud Abdel-ZaherKhalaf Mona Mohamed AliAbed Gamal HassanRamadan Nancy KAbdel-Hakeem Sally SalahAbdel-Hakeem Sara Salah - Chlorine dioxide (ClO) is a potent oxidative disinfectant with potential use in bacterial disease control; however, its antibacterial mechanism and its influence on host redox-immune responses during Aeromonas salmonicida infection in rainbow trout (Oncorhynchus mykiss) remain unclear. Here, we evaluated the antibacterial activity of ClO against common bacterial pathogens, examined its thiol-targeting antibacterial mechanism, and characterized host toxicity, innate immune responses, oxidative stress, and hepatic transcriptomic regulation. ClO markedly inhibited Aeromonas hydrophila and A. salmonicida and reduced bacterial thiol contents in a concentration-dependent manner, indicating that thiol-associated oxidative damage contributes to its antibacterial action. Acute exposure revealed dose-dependent host responses: low-to-moderate ClO exposure activated antioxidant and innate immune responses, whereas higher concentrations caused mortality, liver and gill injury, glutathione depletion, lipid peroxidation, and immune disturbance. RNA-seq analysis showed that ClO exposure and A. salmonicida infection both affected xenobiotic metabolism, glutathione metabolism, lipid metabolism, and immune-related pathways. In the AsClO vs As comparison, 1,877 differentially expressed genes were identified and were mainly enriched in drug metabolism-cytochrome P450, cytochrome P450-mediated xenobiotic metabolism, glutathione metabolism, PPAR signaling, C-type lectin receptor signaling, and cytokine-cytokine receptor interactions. qRT-PCR confirmed the regulation of representative immune-metabolic genes, including mmp9, fmo5, cyp3a27, mgst1, fabp1, apoa-i-2, and bnip3. These findings indicate that ClO suppresses Aeromonas through thiol-associated oxidative damage while modulating hepatic redox-immune and metabolic networks during bacterial infection, providing new insight into host-pathogen-disinfectant interactions in rainbow trout. - Source: PubMed
Publication date: 2026/09/03
Cao BaoruiQin YanHuan TianqingTan JunranLiu EnhuiGu WeiWang GaochaoGe KaiboSun YunchaoLi DatianFan PengLiu MinXu Gefeng - Burn injuries, especially in diabetic patients, are difficult to treat because of persistent inflammation, impaired angiogenesis, and defective remodeling of the extracellular matrix (ECM). A hydrogel based on hyaluronic acid, chitosan, and alginate was developed to deliver adipose-derived mesenchymal stem cells (MSC) overexpressing SPARC (secreted protein acidic and rich in cysteine). SPARC is an ECM glycoprotein that promotes angiogenesis, collagen deposition, and matrix remodeling and whose activity is reduced in diabetic wounds - was overexpressed to restore these regenerative functions, and the therapeutic effect of the system was evaluated in diabetic and non-diabetic mice with deep thermal burns. The animals were treated with control (CMV) MSC, SPARC‑MSC, or SPARC‑MSC embedded in the hydrogel (SPARC‑HG). Wound healing was assessed by planimetry, histopathology, immunofluorescence, immunohistochemistry, qRT-PCR, and RNA sequencing. SPARC‑HG accelerated wound healing from day 9 and achieved near-complete re-epithelialization by day 21, even in diabetic mice. Histological analysis showed accelerated granulation-tissue formation, increased collagen deposition, and a more organized skin architecture. Immunofluorescence revealed an increased density of CD31 microvessels, activation of α-SMA myofibroblasts, proliferation of PCNA keratinocytes, and the involvement of CK15 hair-follicle stem cells. Immunohistochemistry confirmed decreased expression of the pro-inflammatory cytokines IL‑6, TNF‑α and IL‑1β. qRT-PCR and RNA-seq demonstrated the upregulation of angiogenic (CD31, Cdh5), matrix (Col1a1), and anti-inflammatory (IL-10) genes, together with the downregulation of Mmp9 and IL-6. Transcriptomic profiling revealed the enrichment of pathways related to ECM organization, collagen fibrillogenesis, endothelial integrity, and PI3K‑Akt signaling. SPARC-MSC and hydrogel in combination generated a synergistic regenerative environment with restoration of angiogenesis and matrix remodeling, promotion of epithelial proliferation and re-establishment of immune balance, resulting in superior healing outcomes. This platform can be a promising approach to treat severe burns, especially in diabetic patients. - Source: PubMed
Publication date: 2026/09/01
Merzlikin NikitaHan MiaoZhu WenlongZhang ZenyuLiu QianqiuTian HongKaiGerunova LiudmilaLi NaHua JinLian