CD44 (Phospho-Ser706) Antibody
- Known as:
- CD44 (Phospho-Ser706) Antibody
- Catalog number:
- 11911
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- CD44 (Phospho-Ser706) Antibody
Related genes to: CD44 (Phospho-Ser706) Antibody
- Gene:
- CD44 NIH gene
- Name:
- CD44 molecule (Indian blood group)
- Previous symbol:
- MIC4, MDU2, MDU3
- Synonyms:
- IN, MC56, Pgp1, CD44R, HCELL, CSPG8
- Chromosome:
- 11p13
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2019-04-23
Related products to: CD44 (Phospho-Ser706) Antibody
Related articles to: CD44 (Phospho-Ser706) Antibody
- Spontaneous ovarian hyperstimulation syndrome (OHSS) is closely associated with follicle stimulating hormone receptor (FSHR) functional mutations. We observed that estrildid finches naturally carry the gain-of-function FSHR p.Thr449Ala mutation found in humans, yet do not develop OHSS, thereby providing a novel and system to study aspects of OHSS prevention. Cross-species single-cell analysis revealed that macrophages, the most abundant immune cells in ovaries, play a pivotal role in OHSS progression. Macrophage depletion exacerbates the manifestations of OHSS in both birds and rats. Pharmacological activation of the G protein-coupled receptor 183 (GPR183) in ovarian macrophages, significantly alleviates OHSS symptoms. Mechanistically, GPR183 activation in macrophages maintains ovarian immune homeostasis by downregulating inflammatory factors (Interleukin 1 alpha: IL1A, Interleukin 6: IL6, Interleukin 1 beta: IL1B) and upregulating immune regulators responsive to external stimuli (sphingomyelin phosphodiesterase acid like 3A: Smpdl3a, Macrophage-expressed gene 1: Mpeg1, Epithelial stromal interaction 1: Epsti1, Unc-93 homolog B1: Unc93b1, Apolipoprotein B mRNA editing enzyme catalytic subunit 1: Apobec1). It markedly altered CD44 molecule (CD44)/Syndecan-4 (SDC4) -mediated intercellular communication between macrophages and endothelial/stromal cells, thereby modulating the ovarian microenvironment. This study identifies ovarian macrophages as a key therapeutic target for OHSS and proposes GPR183 as a novel receptor target for precision macrophage-based interventions. - Source: PubMed
Publication date: 2026/05/05
Yan XiaofeiHuang YongjieYang JiabaoMa SuLiu SongsongHuang XuanBrosius JuergenZheng HuapingYao BingChen LiLai ShanshanDeng Cheng - The fat mass and obesity-associated protein (FTO), an N6-methyladenosine (m6A) demethylase, plays a crucial role in various cancers. This study investigates its expression and functional role in bladder cancer (BCa). Analysis of TCGA data and validation in BCa cell lines revealed that FTO is significantly overexpressed in bladder cancer tissues and is associated with poor overall and disease-free survival. Functional assays demonstrated that knockdown of FTO markedly increased global m6A RNA methylation and suppressed the proliferation, migration, invasion, and colony formation of BCa cells in vitro. Furthermore, FTO depletion significantly inhibited tumor growth and experimental liver colonization in nude mouse xenograft models. Mechanistically, transcriptomic analysis of FTO-high patient tissues and FTO-knockdown cells revealed a strong association between FTO and epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) pathways. Consequently, FTO knockdown impaired the self-renewal capacity of BCa cells and downregulated the expression of key stemness genes (CD133, CD44, Nanog, OCT4). These findings suggest FTO is a critical oncoprotein that promotes bladder cancer progression and stemness-associated phenotypes, highlighting its potential as a therapeutic target and prognostic marker. - Source: PubMed
Publication date: 2026/05/02
Wu NapingHe Xiaozhou - This study aims to examine the role of exosomes derived from human urine-derived stem cells (hUSCs-Exo) in the construction of a composite structure comprising hUSCs and a porcine urethral decellularized matrix. hUSCs-derived exosomes were isolated and characterized, and hUSCs were treated with varying exosome concentrations to assess migration using scratch and Transwell assays. Dio-labeled hUSCs were seeded onto porcine urethral decellularized matrices and grouped by exosome concentration (0, 50, 100 μg/mL). Cell proliferation and distribution were examined under a fluorescence inverted microscope on days 1, 3, and 7. On day 7, samples were paraffin-embedded for histological analysis of cell integration. hUSCs with mesenchymal stem cell (MSC) properties were successfully isolated, and exosomes extracted via centrifugation. hUSCs-exosome (Exo) enhanced cell migration but did not significantly affect proliferation. Dio-labeling and H&E staining confirmed hUSC presence and attachment to the urethral matrix, while CD44 immunohistochemistry confirmed the presence and attachment of hUSCs within the scaffold. Exosomes derived from hUSCs did not significantly enhance cell proliferation in the construction of the porcine urethral decellularized matrix-hUSC complex. The specific exosomal cargo responsible for these differential effects on migration versus proliferation was not examined in this study and will be the focus of future investigations. - Source: PubMed
Publication date: 2026/05/04
Zhang Kai-YueZhong HaoMa Wei-DeYang Xiao-YanHan Li-ZhongLiu Zhi-Zhong - Chromoblastomycosis (CBM) is a chronic, neglected tropical fungal infection. Its immunopathogenesis, particularly the mechanism underlying its chronicity, remains poorly understood. - Source: PubMed
Publication date: 2026/04/17
Lei KexinTian JieZhang LuGong ZhuoqingLiu WenjieWan ZheWang YangLi RuoyuDong BilinWang Xiaowen - Injectable sodium hyaluronate (NaHA) is extensively utilized in aesthetic medicine as a dermal hydrating agent. However, there are few standardized, human-relevant preclinical methods that can reliably evaluate the moisturizing performance of those products. Existing animal and simplified cell-based models show restricted physiological relevance and insufficient sensitivity. To address this gap, we established a depot-mimicking reconstructed human full-thickness skin (RhFS) platform incorporating an inclusion-based intradermal delivery strategy. Instead of conventional mixing, this strategy mimics the clinical 'depot effect' of intradermal injection, allowing for the simultaneous assessment of cellular responses and tissue-level hydration dynamics. It forms a localized NaHA depot within the dermal compartment of RhFS and preserves spatial hydration gradients, which are lost when NaHA is mixed homogenously. The platform integrates physicochemical characterization of polymer-bound water states with cellular and tissue-level functional readouts. By quantifying key biomarkers, including CD44, aquaporin-3 (AQP3) and natural moisturizing factors (NMFs), our results demonstrate that the inclusion-based delivery strategy significantly outperforms conventional mixing approaches in activating epidermal hydration pathways. Crucially, this platform effectively distinguished the moisturizing efficacy of multiple commercial NaHA formulas, thereby revealing a structure-activity relationship between water-binding states and biological outcomes. Overall, this study presents a reproducible, mechanism-informed and human-relevant framework for preclinical performance evaluation of NaHA-based injectable biomaterials and provides a sensitive alternative to conventional animal-based approaches. - Source: PubMed
Publication date: 2026/02/09
Shi JianfengXu WennaLiu HongfuShan FengjuanWang RuiKe LinnanHan QianqianLu Yong