MuSK (Phospho-Tyr755) Antibody
- Known as:
- MuSK (Phospho-Tyr755) Antibody
- Catalog number:
- 11837
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- MuSK (Phospho-Tyr755) Antibody
Related genes to: MuSK (Phospho-Tyr755) Antibody
- Gene:
- MUSK NIH gene
- Name:
- muscle associated receptor tyrosine kinase
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 9q31.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-04-10
- Date modifiied:
- 2016-10-05
Related products to: MuSK (Phospho-Tyr755) Antibody
Related articles to: MuSK (Phospho-Tyr755) Antibody
- Myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction caused by antibodies against the acetylcholine receptor (AChR) or muscle-specific kinase (MuSK). Although these antibodies enable diagnosis, they correlate poorly with disease activity and prognosis. Emerging data suggest that MG involves broader neuroimmune mechanisms beyond the peripheral synapse. Glial fibrillary acidic protein (GFAP), a marker of astroglial activation, and neurofilament light chain (NfL), a marker of neuroaxonal injury, have been proposed as circulating biomarkers in several neurological diseases. This study aimed to evaluate serum GFAP and NfL concentrations in MG patients and assess its potential diagnostic utility. - Source: PubMed
Publication date: 2026/05/02
Gambino Caterina MariaAgnello LuisaScazzone ConcettaTamburello MartinaMasucci AnnaVassallo RobertaDi Stefano VincenzoBrighina FilippoCiaccio Marcello - Myasthenia gravis is an autoimmune disorder characterized by muscle weakness due to impaired neuromuscular transmission. While antibodies against the acetylcholine receptor and muscle-specific kinase are commonly used for diagnosis, a subset of patients remains seronegative, necessitating alternative biomarkers. Low-density lipoprotein receptor-related Protein 4 antibodies have emerged as a potential diagnostic marker in seronegative myasthenia gravis cases. However, misleading positive results have obscured diagnosis and management. This study explores the clinical relevance of low-density lipoprotein receptor-related Protein 4 antibodies in myasthenia gravis through four patient case studies. Patients presenting with concern for myasthenia gravis underwent a comprehensive diagnostic evaluation, including antibody testing for acetylcholine receptor, muscle-specific kinase, and low-density lipoprotein receptor-related Protein 4. Volitional single-fiber electromyography was also performed. All tests were employed per standardized laboratory protocols. All four patients were initially evaluated for suspected myasthenia gravis; however, despite positive low-density lipoprotein receptor-related Protein 4 antibody results, comprehensive clinical and electrophysiological evaluation ultimately excluded the diagnosis of myasthenia gravis. These cases underscore the limitations of low-density lipoprotein receptor-related Protein 4 antibody testing. - Source: PubMed
Publication date: 2026/04/30
Kinnard Katherine RosellaKhalid Ehtesham - Lipopolysaccharide (LPS) induces inflammation and sepsis through Toll-like receptor 4 (TLR4) activation. Common laboratory animals do not exhibit emesis, but administration of LPS in piglets, cats, and dogs induces emesis via peripheral mechanisms. However, no studies have confirmed whether TLR4 is involved or whether TLR4 antagonists have clinical utility as anti-emetics. - Source: PubMed
Publication date: 2026/05/01
Liu LupingLu ZengbingLiu Julia Yuen HangNgan Man PiuTse Kai-HeiRudd John Anthony - Respiratory failure has various causes, including neuromuscular disorders. We report a case of myasthenic crisis requiring intensive care after a delayed diagnosis. - Source: PubMed
Publication date: 2026/04/26
Yamamoto YukiOnoe AtsunoriOno ShoheiNakamura YoshihiroOishi TakahiroNakamura FumikoNakajima MariSakuramoto KazuhitoMuroya TakashiKajino KentaroIkegawa HitoshiKuwagata Yasuyuki - - Source: PubMed
Publication date: 2026/04/27
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