Gab2 (Phospho-Ser623) Antibody
- Known as:
- Gab2 (Phospho-Ser623) Antibody
- Catalog number:
- 11803
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- Gab2 (Phospho-Ser623) Antibody
Related genes to: Gab2 (Phospho-Ser623) Antibody
- Gene:
- GAB2 NIH gene
- Name:
- GRB2 associated binding protein 2
- Previous symbol:
- -
- Synonyms:
- KIAA0571
- Chromosome:
- 11q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-01-24
- Date modifiied:
- 2015-11-18
Related products to: Gab2 (Phospho-Ser623) Antibody
Related articles to: Gab2 (Phospho-Ser623) Antibody
- Despite expanding therapeutic options, the prognosis of lung squamous cell carcinoma (LUSC) remains poor. Immune checkpoint inhibitors benefit only a subset of patients, and epithelial-mesenchymal transition (EMT) has been implicated in invasion, metastasis, treatment resistance, and immune heterogeneity. Therefore, EMT-related biomarkers may offer improved risk stratification. - Source: PubMed
Publication date: 2026/05/01
Zhang AnqiHe JinpingLin Qiang - Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality. Although targeted therapies and immunotherapies have improved outcomes, many patients exhibit limited responses due to primary or acquired resistance, underscoring the need to identify novel molecular targets. The Gab family of scaffolding adaptors, including GAB1 and GAB2, are recognized oncogenic regulators, whereas the role of GAB3, implicated in immune cell activation, is poorly defined in solid tumors. Here, we identify GAB3 as a novel tumor suppressor in LUAD. Pan-cancer analysis revealed frequent GAB3 downregulation, and high GAB3 expression was associated with favorable prognosis. Functionally, GAB3 overexpression suppressed LUAD cell proliferation, migration, invasion, and tumor growth in vitro and in vivo. Mechanistically, GAB3 interacted with LYN kinase to inhibit the MAPK signaling pathway and reverse epithelial-mesenchymal transition (EMT). In addition, GAB3 remodeled the tumor immune microenvironment, enhanced CXCL10 secretion, increased CD8 T cell infiltration and effector function, and potently sensitized tumors to anti-PD-1 therapy. Our findings support a dual tumor-suppressive mechanism for GAB3 and propose it as a promising prognostic biomarker and therapeutic target in LUAD. - Source: PubMed
Publication date: 2026/04/22
Wang DiXiao ChuFan TaoDeng ZiqinYin HongfeiLiu YixiaoLi JiaJi YuCai WenpengLiao TianleLi JiayanLi ChunxiangHe Jie - Glioma, the most common primary intracranial tumor, exhibits high recurrence and mortality rates. Ginsenoside-Rh2 (GS-Rh2), an active compound from , has shown anti-tumor potential. Gab2, a tyrosine kinase substrate, is implicated in glioma pathogenesis; however, the mechanism by which GS-Rh2 might inhibit glioma cell migration and invasion via the Gab2/Akt2 pathway remains unexplored. - Source: PubMed
Publication date: 2026/04/01
Sun WeiLi RuifangWang LinjuanHan WenjieLi JiakeXu ShuangliSun Xiuning - Antibiotic-resistant bacteria (ARB) and their associated antibiotic resistance genes (ARGs) represent a growing threat in clinical settings. ARB and ARGs from environmental ecosystems can persist in their native habitats and potentially transfer to human and animal pathogens. spp. has emerged as a notable nosocomial pathogen and is increasingly recognized as a bioindicator of antibiotic resistance in aquatic environments. Thus, spp. may play a pivotal role in the mobilization and dissemination of ARGs. This review synthesizes current literature on the presence and diversity of integrons, genetic elements that facilitate the horizontal transfer of resistance genes, within spp. isolated from aquatic ecosystems. Class 1 integrons are the most frequently reported in , although class 2 integrons have also been detected across various species and geographic regions. A substantial proportion of integron-positive isolates exhibit multidrug resistance (MDR). Moreover, diverse gene cassettes arrays have been identified in different strains, reflecting a high level of genetic variability. In conclusion, spp. represent a significant reservoir and vector for ARGs in aquatic systems, with the potential to transfer these resistance determinants to other pathogenic bacteria through drinking water and the food chain, thereby posing a public health risk. - Source: PubMed
Publication date: 2026/03/24
Hassen BilelAbbassi Mohamed Salah - Chemotherapy-induced ncRNA-mediated plasticity is an emerging concept in cancer research. To that end, we observed a cisplatin-responsive regulatory program centered on piRNA activation. OSCC cells exposed to cisplatin markedly promoted the piRNA expression, with piR-hsa-30937 showing the most prominent upregulation. Mechanistically, cisplatin disrupts the OCT1-DNMT1 repressive complex that mediates DNA methylation of transcription factor binding sites of piR-hsa-30937, to derepress its expression. Functionally, piR-hsa-30937 targets GAB2 and sensitizes OSCC cells to cisplatin by suppressing proliferation, enhancing apoptosis, and γ-H2AX accumulation. Furthermore, GAB2 overexpression reversed these effects and desensitized OSCC cells to cisplatin by activating NF-κB-mediated JNK suppression. Overall, cisplatin actively remodels the OCT1-DNMT1-piR-hsa-30937 axis regulating piRNA expression, which in turn potentiates cisplatin cytotoxicity by attenuating GAB2-mediated survival signaling in OSCC. - Source: PubMed
Publication date: 2026/02/02
Lalruatfela AnthonyBiswal PriyajitBehera Subham KumarBiswal SrutiBehera Deepak KumarDash Jiban JyotiMallick Bibekanand