Gab2 (Phospho-Tyr643) Antibody
- Known as:
- Gab2 (Phospho-Tyr643) Antibody
- Catalog number:
- 11802
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- Gab2 (Phospho-Tyr643) Antibody
Related genes to: Gab2 (Phospho-Tyr643) Antibody
- Gene:
- GAB2 NIH gene
- Name:
- GRB2 associated binding protein 2
- Previous symbol:
- -
- Synonyms:
- KIAA0571
- Chromosome:
- 11q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-01-24
- Date modifiied:
- 2015-11-18
Related products to: Gab2 (Phospho-Tyr643) Antibody
Related articles to: Gab2 (Phospho-Tyr643) Antibody
- Chlamydia trachomatis (Ct) is an obligate intracellular bacterium that can cause severe reproductive complications, including infertility and pelvic inflammatory disease. Its pathogenicity depends on intracellular maturation, which involves differentiation between infectious elementary (EB) and replicative reticulate bodies within inclusion vacuoles. Ct is known to modulate host PI3K-AKT signaling during this process; however, the molecular basis of this regulation remains unclear. To elucidate this mechanism, we screened host factors linked to the PI3K-AKT axis using a PI3K-AKT-mTOR compound library comprising 319 inhibitors, and identified the adaptor protein Gab2 (GRB2-associated binding protein 2) as a new target molecule of Ct. Gab2 protein levels decreased during the late phase of infection, and Gab2 silencing impaired intracellular replication without affecting EB formation. These findings demonstrate that Ct infection modulates the host adaptor Gab2 during intracellular development and provide new insights into host-pathogen interactions underlying chlamydial maturation. - Source: PubMed
Publication date: 2026/07/01
Kuroiwa SoraDeguchi TaikiOkubo TorahikoNakamura ShinjiHigashi HideakiYamaguchi Hiroyuki - Immunosuppressive tumor-associated macrophages (TAMs) in the malignant ascites contribute to Poly (ADP-ribose) polymerase inhibitor (PARPi) resistance in ovarian cancer (OC). - Source: PubMed
Publication date: 2026/06/18
Liu QingbaoTang QinYe WeiChen BingZhong YanSong YonghongWang ShengZhou KechengJiang XiangxiangWang Jing - While the molecular characteristics of cutaneous melanomas (CMs) in individuals with light skin have been extensively studied, less is known about acral melanoma (AM), a non-ultraviolet radiation-induced melanoma more frequently found in individuals with darker skin. Exome and whole genome sequencing of 25 AMs from South African patients with a range of ancestral backgrounds were performed. While close to 50% in CMs, only one AM in a patient of European ancestry harbored an alteration at p.V600 in BRAF. 76% of tumors were triple wild-type. There were hotspot mutations in KIT, mutations in genes encoding components of the MAPK pathway (K57N in MAP2K1 and Y71H in HRAS), and novel candidate driver mutations in genes including PROS1, RGPD3, and SF3A3. Copy number gains included regions with TERT, CDK4, PAK1/GAB2, and DAD1 (chr14q11.2). Gain of chr17q25.1 harboring CDK3 was seen in samples with African ancestry. Eleven significantly deleted regions included chr1q43 (MAP1LC3C) and homozygous deletions of HLA-DRB1, PHF10 (chr6q27), and ATMIN (chr16q23). Mutational signatures included chromosomal instability and chromothripsis. There was a robust ancestry-related difference in tumor evolutionary dynamics where African ancestry was correlated with more genome doubling and clonality with less evolutionary branching. - Source: PubMed
Tod BiancaNam YoonheeKaya Deniz EceKotze MarithaSchneider JohannSanderson-November MichellineVisser Willem IBegani PriyaZhao JunfeiZhu AllenJanuszewski Adamde Wet JohannWedge David CRabadan RaulBowcock Anne M - Facial morphology is a highly heritable human trait, yet its underlying genetic architecture remains largely unresolved despite recent progress from genome-wide association studies (GWAS). Here, we integrated univariate and multivariate analyses of 230 facial phenotypes with GWAS and epigenome-wide association studies to identify genomic and epigenomic markers influencing facial variation in Chinese populations. Univariate analyses identified 144 single nucleotide polymorphisms (SNPs) and 34 CpG methylation sites, whereas multivariate canonical correlation analyses detected an additional 80 SNPs and 734 CpG sites across four key facial regions (eyebrow-eye complex, nose, mouth, and facial contour), with 50 SNPs overlapping those from the univariate analysis. In total, 174 SNPs and 768 CpG sites were associated with facial morphology, with 70.1% of SNPs and 57.5% of CpG sites linked methylation quantitative trait loci validated in a replication cohort. Functional mapping and annotation of GWAS prioritized 42 lead SNPs near genes such as SOX9, VPS13B, GAB2, and DOCK9, emphasizing their roles in craniofacial development. Notably, CpG sites accounted for more phenotypic variance in facial morphology (mean 8.83%, max 13.68%) than SNPs alone (mean 2.85%, max 6.63%). Integrating both genomic and epigenomic markers further enhanced the explainable variance (mean 9.85%, max 16.57%). This study represents the first comprehensive analysis of both genomic and epigenomic influence on facial morphology in Chinese populations. Our findings demonstrate that CpG methylation, alongside SNPs, contributes substantially to facial variation, explaining an even greater proportion of morphological variance and underscoring the importance of epigenetic regulation in shaping facial morphology. - Source: PubMed
Publication date: 2026/06/09
Kong YongqiangZou LixinZhao YiruJi PengchaoChen XuanzhuWu ShaoyuanZhao WentingWei YiliangLi Caixia - The buffalo is an important agricultural species due to its many productive characteristics, which encourage its use worldwide. Uncovering the processes of selective sweeps is critical for a comprehensive understanding of genomic mechanisms that influence phenotypic differentiation in buffalo. This study aims to refine signatures of selection in Bulgarian (BUL), Hungarian (HUN), and Romanian (ROM) buffalo breeds using runs of homozygosity (ROHs), the integrated haplotype score (iHS), the standardized log-ratio of the integrated site-specific extended haplotype homozygosity (EHH) between pairs of breeds test (Rsb), and cross-population EHH (XP-EHH) approaches. The SNP dataset of 160 genotypes from BUL, HUN, and ROM buffalo breeds was genotyped using the Axiom Buffalo Genotyping Array 90K from Affymetrix. By combining the ROH, iHS, Rsb, and XP-EHH methods, we identified many important genomic regions and candidate genes associated with milk production (, , and ), reproduction (, , , , and ), growth (, , and ), immune response (, , , and ), and adaptation () in BUL, HUN, and ROM buffalo breeds. Our findings highlighted selection signals and genes related to important economic traits in the BUL, HUN, and ROM buffalo breeds, providing promising candidate genes for further research and inclusion in conservation and selection plans for these breeds. - Source: PubMed
Publication date: 2026/05/16
Saleh Medhat SZaghloul Abdelfatah RCarpio Mayra GómezPierini ClaudiaDe Palo PasqualeLandi Vincenzo