MAP2K3 (Phospho-Thr222) Antibody
- Known as:
- MAP2K3 (Phospho-Thr222) Antibody
- Catalog number:
- 11741
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- MAP2K3 (Phospho-Thr222) Antibody
Related genes to: MAP2K3 (Phospho-Thr222) Antibody
- Gene:
- MAP2K3 NIH gene
- Name:
- mitogen-activated protein kinase kinase 3
- Previous symbol:
- PRKMK3
- Synonyms:
- MEK3, MKK3, MAPKK3
- Chromosome:
- 17p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-11-11
- Date modifiied:
- 2016-10-05
Related products to: MAP2K3 (Phospho-Thr222) Antibody
Related articles to: MAP2K3 (Phospho-Thr222) Antibody
- 1. Egg production is a primary economic driver in the poultry industry, determining the total yield of commercial layers. However, the complex polygenic mechanism remains largely elusive. This study investigated the phase-specific genetic mechanisms of egg production using a high-precision genomic approach.2. A genome-wide association study (GWAS) was conducted on a layer population ( = 3,587). Egg numbers were recorded across four distinct production phases: onset to 300 days, 301 to 560 days, 561 to 651 days and the cumulative onset to 651 days period. Following whole-genome SNP genotyping, GWAS signals were integrated with functional enrichment analyses to prioritise key loci and candidate genes associated with egg‑number traits.3. A total of 425 significant SNP were identified across the evaluated phases. Functional annotation revealed significant enrichment in 47 GO terms and four KEGG pathways, primarily involved in cell cycle regulation, cytoskeleton assembly and reproductive development. , and were highlighted as compelling candidate genes. Potential genetic markers were identified, including rs14072717 within , a cluster of nine SNP within the locus and three variants within .4. These findings elucidated the dynamic genetic regulation of egg production throughout the laying cycle and highlight , and as genomic targets. These markers provide a foundation for marker-assisted selection to enhance egg yield and production persistency in poultry. - Source: PubMed
Publication date: 2026/08/19
Ni YHuang SBai TKhurshid KZhao XLiu XQin SWang HLiu LZhao MGe JGeng TGong DGong H - Maturity Onset Diabetes of the Young (MODY) remains an underdiagnosed condition with remarkable genetic variability across populations. While diagnostic tools are based on Caucasian cohorts, Whole Exome Sequencing (WES) studies are needed to identify new genes in non-Caucasians, as up to 77% of patients do not harbor variants of significance in MODY-known genes. No WES studies have addressed the genomic landscape of MODY beyond its canonical genes in Latino populations. We aimed to characterize the genomic landscape of MODY through WES in a Mexican cohort, comparing cases with type 2 diabetes mellitus (T2DM) patients and healthy controls (HC). - Source: PubMed
Publication date: 2026/07/01
Moscona-Nissan AlbertoMarrero-Rodríguez DanielAndonegui-Elguera SergioLuna-Ávila Eduardo SalifMartínez-Mendoza FlorenciaVela-Patiño SandraRamírez-Ramos ItzelHinojosa-Alvarez SilviaHernandez-Perez JesusChavez-Santoscoy Rocio AMercado-Medrez SophiaLeón-Wu Kapy SDe Miguel-Ibáñez ReginaMercado MoisésTaniguchi-Ponciano KeikoFerreira-Hermosillo Aldo - Deoxynivalenol (DON), a widely prevalent mycotoxin in temperate climates, causes significant hepatic injury upon the consumption of contaminated cereals. However, the key targets and mechanisms underlying DON-induced inflammatory hepatic injury remain unclear, thus hindering the development of targeted therapeutics. - Source: PubMed
Publication date: 2026/06/06
Yang YaqinWu YueXu XiaoqingIhsan AwaisHan LiWang Xu - The perioperative period represents a critical window in cancer management, during which anesthetic choice may influence tumor biology. Sevoflurane, a volatile anesthetic widely used in neurosurgery, has been shown to modulate gene expression in glioblastoma (GBM). This study aimed to identify novel biomarkers in GBM and to investigate their functional roles and prognostic significance, thereby exploring the potential impact of this common perioperative agent on tumor behavior and patient outcomes. - Source: PubMed
Publication date: 2026/05/22
Tang RuiChen HuYan YaLei Xiaofeng - Pulmonary vascular remodeling (PVR) is primarily driven by the aberrant proliferation and migration of vascular cells, with pulmonary artery smooth muscle cells (PASMCs) playing a central role. High mobility group protein B1 (HMGB1), a damage-associated molecular pattern (DAMP) molecule, is released via apoptosis, necrosis, or inflammatory cell activation and contributes to the pathological progression of various cardiopulmonary diseases. However, the mechanism by which HMGB1 regulates PASMCs to participate in PVR remains to be elucidated. PASMCs were stimulated with recombinant HMGB1. Proliferation of PASMCs was detected using CCK-8 and EdU assays, and migration of PASMCs was assessed by cell scratch and Transwell experiments. RNA-Seq was performed to profile transcriptomic changes in HMGB1-treated PASMCs, followed by bioinformatic analysis to identify DEGs and associated signaling pathways. Validation of DEGs was conducted using qRT-PCR and Western blotting. Monocrotaline (MCT) constructs a rat pulmonary vascular remodeling model to verify protein expression levels. HMGB1 treatment upregulated MAP2K3 expression and activated p38 phosphorylation in PASMCs, driving cell proliferation and migration. Silencing MAP2K3 or administering the p38 inhibitor SB203580 reversed the HMGB1-induced cellular functional changes and downregulated the expression of inflammatory cytokines (IL-1β, IL-6, TNF-α). HMGB1 also upregulated the Bcl-2/Bax ratio, inducing apoptosis resistance, while the inhibitors restored apoptotic balance. In a rat model of MCT-induced pulmonary vascular remodeling, MAP2K3 expression and p38 phosphorylation levels were significantly elevated, accompanied by pathological changes such as vascular wall thickening and increased muscularization. In addition, intervention with the HMGB1 inhibitor glycyrrhizin or SB203580 blocked MAP2K3/p38 activation, alleviated pulmonary vascular remodeling, inhibited cell proliferation, and restored apoptotic balance. This study elucidates that HMGB1 may drive PASMC proliferation and migration via the MAP2K3/p38 signaling axis, thereby contributing to pulmonary vascular remodeling. These findings provide new ideas for the treatment of pulmonary vascular remodeling diseases. - Source: PubMed
Publication date: 2026/05/29
Wang Ya-MeiWang Wen-TingLiang Jia-YiXu Wen-JingLi Hao-YanGao Yu-TaoWang Huan-Liang