STMN1 (Phospho-Ser62) Antibody
- Known as:
- STMN1 (Phospho-Ser62) Antibody
- Catalog number:
- 11722
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- STMN1 (Phospho-Ser62) Antibody
Related genes to: STMN1 (Phospho-Ser62) Antibody
- Gene:
- STMN1 NIH gene
- Name:
- stathmin 1
- Previous symbol:
- LAP18, C1orf215
- Synonyms:
- SMN, OP18, PR22, PP19, PP17, Lag, FLJ32206
- Chromosome:
- 1p36.11
- Locus Type:
- gene with protein product
- Date approved:
- 1990-12-17
- Date modifiied:
- 2014-11-19
Related products to: STMN1 (Phospho-Ser62) Antibody
Related articles to: STMN1 (Phospho-Ser62) Antibody
- The tumor microenvironment (TME) of gastric adenocarcinoma is exceptionally heterogeneous, and epithelial-mesenchymal transition (EMT) is a central mechanism promoting local invasion and metastatic spread. Even so, how EMT-programmed cells are spatially arranged within tumor tissue, how they interact with neighboring immune populations, and which molecular nodes might be exploited therapeutically remain incompletely defined. - Source: PubMed
Publication date: 2026/09/07
Li JianwenQin ZitongWang TingLi WeipingMa JinminGuan Quanlin - Paclitaxel is a cornerstone microtubule-stabilizing agent, but intrinsic and acquired resistance limit durable benefit. Resistance emerges from interacting changes in drug transport, tubulin composition, microtubule regulation, mitotic fate, apoptosis, autophagy, cellular plasticity and the tumor microenvironment. The stathmin family-STMN1, STMN2, STMN3 and STMN4-controls microtubule assembly through tubulin sequestration and catastrophe-promoting activity and therefore occupies a direct functional interface with paclitaxel pharmacodynamics. STMN1 has the strongest evidence: overexpression can reduce taxane sensitivity, whereas suppression restores microtubule stabilization and drug response in several experimental systems; clinical studies also associate high STMN1 with unfavorable outcome or reduced taxane benefit in selected cancers. Evidence for STMN3 is narrower but includes a mechanistically relevant ovarian-cancer study in which bisphosphorylated PEA-15 sensitized cells to paclitaxel by attenuating SCLIP/STMN3-mediated microtubule destabilization. By contrast, direct evidence for STMN2 and STMN4 in taxane response remains insufficient. This review develops a microtubule-centered resistance model, distinguishes established findings from context-dependent observations and testable hypotheses, and evaluates biomarker and therapeutic strategies targeting stathmin expression, phosphorylation, stability and protein interactions. We propose that stathmin activity is most likely to have clinical value as part of a composite taxane-response classifier that also incorporates intracellular drug exposure, tubulin isotypes and apoptotic competence. - Source: PubMed
Publication date: 2026/09/01
Li HaoyuShi LizhouWang QinghuaHan Wei - Gastric cancer is a heterogeneous disease in which cancer stem cell-associated properties may contribute to tumor heterogeneity and progression. This study aimed to establish paired normal and tumor gastric organoids, characterize stemness-related gene expression, and explore its association with organoid formation. - Source: PubMed
Publication date: 2026/08/31
Yoo Yie-RiJeong KyoungyunYoo JaeunKim Hyun MyongShin Ji-YeonKang Min KyuPark KyoyoungKim Sa-HongKim ChungyoonKim JeesunPark Young SukKong Seong-HoLee Hyuk-JoonYang Han-KwangPark Do Joong - Glioblastoma (GBM) is among the most aggressive primary brain tumors, marked by rapid proliferation, therapeutic resistance, and profound intratumoral heterogeneity. Epigenetic regulators such as lysine-specific demethylase 1A (KDM1A) and histone deacetylase 2 (HDAC2) are aberrantly expressed in resistant GBM subpopulations and strongly correlate with poor clinical outcomes. Here, we assessed the therapeutic potential of MPT0G521, a dual KDM1A/class I HDAC inhibitor, in disrupting epigenetic regulation and cell cycle progression. Bioinformatic analyses of resistance-associated gene profiles (temozolomide and 2 Gy radiation) and single-cell transcriptomic datasets from distinct tumor regions revealed enrichment of KDM1A and HDAC2 in high-cycling GBM clusters, particularly at invasive margins prone to recurrence. Functional assays demonstrated that MPT0G521 potently inhibited proliferation of both parental and temozolomide-resistant GBM cells, inducing G2/M arrest and apoptosis. Transcriptomic profiling further identified significant downregulation of centrosome integrity genes (FSD1, KIFC1), spindle regulators (TUBB, STMN1, KIF2C, KIF15), kinetochore components (AURKB, CDCA8, SPAG5), and G2/M checkpoint mediators (CENPF, MYBL2, CCNF, MYT1, CDC25A), resulting in disrupted mitotic progression. Mechanistically, MPT0G521 increased histone H3 methylation and acetylation, validating its dual inhibitory activity against KDM1A and class I HDACs. Collectively, these findings indicate that MPT0G521 disrupts the G2/M activation and mitotic machinery, thereby suppressing proliferative and resistant GBM subpopulations. This dual epigenetic strategy holds strong promise for overcoming GBM heterogeneity and reducing recurrence. - Source: PubMed
Publication date: 2026/09/02
Wu An-ChihChuang Jian-YingLiu Jr-JiunSalim Enrica AngelinaWu Ming-HsiaoJing Shih-WeiHsu Tsung-IChang Kwang-YuChang Wen-ChangThakur AmandeepLiou Jing-PingLo Wei-Lun - Skin is a highly specialized barrier organ, which serves essential barrier, immune, and sensory functions and exhibits conserved structure. In addition, each species exhibits a unique skin transcriptional profile for adapting distinct environmental conditions and physiological demands. However, these transcriptional profiles across mammals remain incompletely understood. In this study, we integrated 61 publicly available skin RNA-seq datasets from eight mammalian species: human (), macaque (), mouse (), sheep (), goat (), donkey (), rabbit (), and pig (). We identified a large number (2286 to 4588) of differentially expressed genes (DEGs) based on 10,504 one-to-one orthologous genes in all pairwise species comparisons. A total of 44 conserved genes were identified by integrating tissue specificity, expression variability, and mean expression level, which were enriched in epidermal development, keratinocyte differentiation, and desmosome organization. We also identified species-specific genes and transcription factors, such as (donkey), (goat), and (mouse), which are associated with the cell cycle, extracellular matrix, and muscle contraction pathways, respectively. WGCNA further revealed goat-associated module 2 (M2) enriched in the negative regulation of angiogenesis. Collectively, this study provides a comprehensive cross-species transcriptional profile resource for mammalian skin, providing a valuable resource for understanding the regulatory plasticity underlying skin evolution across mammals. - Source: PubMed
Publication date: 2026/08/21
Wei Wen-TianZhou ChenHuang Qi-XuanNing Zhong-HuaBai Yi-LinBai Yue-YuXu Song-Song