c-Jun (Phospho-Ser63) Antibody
- Known as:
- c-Jun (Phospho-Ser63) Antibody
- Catalog number:
- 11710
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- c-Jun (Phospho-Ser63) Antibody
Related products to: c-Jun (Phospho-Ser63) Antibody
Related articles to: c-Jun (Phospho-Ser63) Antibody
- - Source: PubMed
Amin FarhanZaman WajidAmin Adnan - This study included 232 patients with diabetic foot ulcers (DFUs) to construct and validate a linear regression model to predict pain during dressing changes and to evaluate the effectiveness of a model-based personalized analgesic care regimen. In stage 1,160 patients were divided into a training set (n = 113) and an internal validation set (n = 47); multivariable linear regression identified ulcer area, ulcer duration, duration of diabetes, and the Self-Rating Anxiety Scale (SAS) score as predictors of continuous dressing-change VAS. The model yielded an adjusted R of 0.458 and an RMSE of 1.719 in the training set, while the validation-set RMSE, calibration intercept, calibration slope, and AUC for identifying high pain were 2.058, 1.414, 0.721, and 0.913, respectively. In stage 2 (72 cases), subjects were assigned to a control group and an intervention group. The intervention group received a personalized analgesic regimen based on model-derived risk stratification, while the control group received conventional analgesic care. After 4 weeks, the intervention group had a lower dressing-change VAS score than the control group (3.83 ± 1.61 vs 4.94 ± 1.91, P = 0.010), together with a higher overall adherence rate (86.11% vs 63.89%, P = 0.029), a higher ulcer area reduction rate (41.84% ± 11.01% vs 26.22% ± 7.55%, P < 0.001), and a shorter wound-healing time (32.0 [29.0-35.0] vs 38.0 [34.0-43.5] days, P < 0.001). The model showed useful discrimination for dressing-change pain, and the model-based personalized analgesic regimen improved short-term pain, adherence, and wound-related outcomes; however, external validation and further refinement of model calibration are required before routine clinical implementation. - Source: PubMed
Publication date: 2026/08/21
Liping LiJunhong WangZhen ZhangHongyan XiaoXiaorong FuJun Xu - Antibiotics contaminating aquatic environments is a challenge for the ONE Health initiative as it poses a risk to biodiversity. Tetracyclines are toxic to a wide range of organisms. The objective of this study was to assess the growth, individual fitness and DNA damage following a short-term exposure to tetracycline in Daphnia magna. Additionally, the long-term effects of DNA damage on population growth rate and individual fitness parameters in the offspring for intergenerations were evaluated. The results indicated that D. magna has a significant effect on tetracycline-induced fertility impairment, resulting in reduced survival and reproductive capacity of the parental groups and impaired growth and development of the offspring. Furthermore, tetracycline treatment resulted in a significant reduction in individual fitness, as evidenced by the significant reduction in maximum body length of D. magna in both tetracycline-exposed generations. D. magna was exposed to concentrations of 25, 50, 100, 200, and 400 mg/L for periods of 24-72 h, with the objective of determining the concentrations that would not be lethal and yet would induce DNA damage. Tetracycline concentrations of 50 and 25 mg/L did not result in excessive levels of cytotoxicity within 72 h. P, F1, and F1 offspring born between 48 and 72 h were tested for DNA damage. D. magna appears to recover from DNA damage, but concerns have been raised about using tetracycline repeatedly in water, as it can lead to higher concentrations and longer exposure times for lots of organisms. - Source: PubMed
Öncel Buse CeydaPekşen Çiğdem AkınTunca BesteKavasoğlu Zeynepİşeri Özlem Darcansoy - High peritoneal transport status has traditionally been linked to adverse outcomes in peritoneal dialysis (PD). However, its clinical relevance in contemporary, individualized PD practice remains unclear. We therefore evaluated its association with long-term outcomes across three successive treatment eras. - Source: PubMed
Publication date: 2026/06/25
Yoon Ho-JoongLee SionKim Ji-HwanKim Sung-GyunKim Jwa-Kyung - COVID-19 vaccine uptake among children remains low. Bundling multiple strategies into a mobile health (mHealth) application (app) may be effective in promoting vaccine uptake. We aimed to determine the effectiveness of a caregiver-facing mHealth app on pediatric COVID-19 vaccine uptake. - Source: PubMed
Publication date: 2026/05/04
Kerns Ellen KOunpraseuth SongthipDarden PaulRoberts James RLee JeannetteNewcomer Sophia RCostello Lisa MHockett Christine WDehority WalterQueen KatieAlamarat ZainWatts Delma-JeanGreer MelodyPhan Ly TChang DiSnowden JessicaMcCulloh Russell J