MMP7 & FASLG Protein Protein Interaction Antibody Pair
- Known as:
- MMP7 & FAS ligand Protein Protein Interaction Antibody Pair
- Catalog number:
- DI0182
- Product Quantity:
- 1 Set
- Category:
- -
- Supplier:
- Abno
- Gene target:
- MMP7 & FASLG Protein Interaction Antibody Pair
Related genes to: MMP7 & FASLG Protein Protein Interaction Antibody Pair
- Gene:
- FASLG NIH gene
- Name:
- Fas ligand
- Previous symbol:
- APT1LG1, TNFSF6
- Synonyms:
- FasL, CD178
- Chromosome:
- 1q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-09
- Date modifiied:
- 2019-04-23
- Gene:
- MMP7 NIH gene
- Name:
- matrix metallopeptidase 7
- Previous symbol:
- MPSL1
- Synonyms:
- PUMP-1
- Chromosome:
- 11q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-15
- Date modifiied:
- 2015-08-25
Related products to: MMP7 & FASLG Protein Protein Interaction Antibody Pair
Related articles to: MMP7 & FASLG Protein Protein Interaction Antibody Pair
- In high-income countries, inflammation has been associated with increased morbidity and mortality in human immunodeficiency virus (HIV)-infected individuals despite treatment with antiretroviral therapy (ART). However, these findings may not be generalizable to low-income settings. - Source: PubMed
Letizia AndrewEller Michael APolyak ChristinaEller Leigh AnneCreegan MatthewDawson PeterBryant ChristopherD KimCrowell Trevor ALombardi KaraRono EricRobb Merlin LMichael Nelson LMaswai JonahAke Julie A - To assess the predictive value of pre-chemotherapy matrix metalloproteinase 7 (MMP-7), soluble Fas (sFas) and Fas ligand (FasL) serum levels, as well as their changes during therapy. - Source: PubMed
Publication date: 2018/06/20
Szarvas TiborSevcenco SabinaMódos OrsolyaKeresztes DávidNyirády PéterCsizmarik AnitaRistl RobinPuhr MartinHoffmann Michèle JNiedworok ChristianHadaschik BorisMaj-Hes AgnieszkaShariat Shahrokh FKramer Gero - Membrane Fas-FasL binding triggers apoptosis, enhanced in chronic kidney disease (CKD). However, the role of soluble forms, sFas and sFasL, remains unclear. Matrix metalloproteinases (MMPs) are known converters of sFasL from the membrane-bound form, but there are no data on relations between sFas/sFasL, MMPs, their tissue inhibitors (TIMPs) or inflammatory/endothelial factors in CKD patients. We aimed to evaluate correlations between sFas, sFasL, MMP-2, MMP-7, MMP-9, TIMP-1, TIMP-2, and the role of sFas/sFasL as markers of inflammation and endothelial dysfunction. - Source: PubMed
Publication date: 2012/08/07
Musiał KingaZwolińska Danuta - The system of membrane receptor Fas and its ligand FasL compose one of the main pathways triggering apoptosis. However, the role of their soluble forms has not been clarified yet. Although sFasL can be converted from the membrane-bound form by matrix metalloproteinases (MMPs), there are no data on relations between sFas/sFasL, MMPs and their tissue inhibitors (TIMPs) in patients on chronic dialysis--neither children nor adults. The aim of our study was to evaluate serum concentrations of sFas, sFasL, and their potential regulators (MMP-2, MMP-7, MMP-9, TIMP-1, TIMP-2), in children and young adults chronically dialyzed. Twenty-two children on automated peritoneal dialysis (APD), 19 patients on hemodialysis (HD) and 30 controls were examined. Serum concentrations of sFas, sFasL, MMPs and TIMPs were assessed by ELISA. Median values of sFas, sFasL, sFas/sFasL ratio, MMP-2, MMP-7, MMP-9, TIMP-1 and TIMP-2 were significantly elevated in all dialyzed patients vs. controls, the highest values being observed in subjects on HD. A single HD session caused the decrease in values of all parameters to the levels below those seen in children on APD. Regression analysis revealed that MMP-7 and TIMP-1 were the best predictors of sFas and sFasL concentrations. Children and young adults on chronic dialysis are prone to sFas/sFasL system dysfunction, more pronounced in patients on hemodialysis. The correlations between sFas/sFasL and examined enzymes suggest that MMPs and TIMPs take part in the regulation of cell death in the pediatric population on chronic dialysis, triggering both anti- (sFas) and pro-apoptotic (sFasL) mechanisms. - Source: PubMed
Musiał KingaZwolińska Danuta - At angle of cell apoptosis, the excessive less of hematopeitic cell apoptosis is a reason of hematopoietic cell accumulation. The Fas/FasL system as an important pathway inducing cell apoptosis participates in occurrence and development of leukemia. Leukemia cells generally are not sensitive or are resistant to Fas/FasL-mediated apoptosis, while it is one of important reasons resulting in immunoescape and unsensitivity of leukemia cells to chemotherapy. In recent years studies related to mechanisms of leukemia cell resistance to Fas/FasL-mediated apoptosis such as Fas and FasL mutation and expression abnormality, Fas signaling transduction pathway abnormality, and regulatory affect of apoptotic regulatory genes on Fas/FasL system, as well as strategies replying to antiapoptosis of leukemia cells including NF-kappab, XIAP, membrane receptor CD28 and matrix metalloproteinase 7 obtained some progresses. The above-mentioned issues were reviewed in this article. - Source: PubMed
Wang Li