GP1BA & F12 Protein Protein Interaction Antibody Pair
- Known as:
- GP1BA & F12 Protein Protein Interaction Antibody Pair
- Catalog number:
- DI0173
- Product Quantity:
- 1 Set
- Category:
- -
- Supplier:
- Abno
- Gene target:
- GP1BA & F12 Protein Interaction Antibody Pair
Related genes to: GP1BA & F12 Protein Protein Interaction Antibody Pair
- Gene:
- GP1BA NIH gene
- Name:
- glycoprotein Ib platelet subunit alpha
- Previous symbol:
- GP1B
- Synonyms:
- CD42b, GPIbalpha
- Chromosome:
- 17p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1990-09-10
- Date modifiied:
- 2019-04-23
Related products to: GP1BA & F12 Protein Protein Interaction Antibody Pair
Related articles to: GP1BA & F12 Protein Protein Interaction Antibody Pair
- Investigating the genetic basis of adaptation to environmental stresses, such as hypoxia, can enhance our understanding of human biology and resilience. High-altitude adaptation provides a valuable model for studying the genetic mechanisms of the hypoxic response. Indeed, most known loci associated with hypoxic adaptation have been identified in indigenous mountain populations; however, research on elite climbers remains limited. In our previous study, we conducted exome sequencing of experienced mountaineers and identified two pathogenic variants in the and genes, both of which are linked to respiratory failure. These findings encouraged this study, which conducted exome sequencing to explore genetic variation in a larger cohort. - Source: PubMed
Maksiutenko Evgeniia MMerkureva Valeriia АBarbitoff Yury AAseev Mikhail VLazareva Tatyana EGlotov Andrey SGlotov Oleg S - To address the forensic diagnostic challenge of distinguishing Anaphylactic Sudden Death (ASD) from Sudden Death from Coronary Heart Disease (SD-CHD), this study established mouse models of Atherosclerosis (AS) and ovalbumin-induced Anaphylaxis (AP). LC-MS/MS-based serum proteomic analysis of Atherosclerosis (AS) and Anaphylaxis (AP) mice identified fibronectin 1 (FN1), platelet glycoprotein Ibα chain (GP1BA), and platelet factor 4 (PF4) as candidate biomarkers. These candidates were validated by parallel reaction monitoring (PRM), enzyme-linked immunosorbent assay (ELISA), and immunohistochemistry (IHC) in a combined AS + AP mouse model and in post-mortem human cardiac and bronchiolar epithelial tissue. In mice, serum FN1, GP1BA, and PF4 levels were significantly elevated in the AS group, whereas only FN1 was markedly downregulated in AP mice. In human tissues, FN1, GP1BA, and PF4 were all upregulated in Sudden death from coronary heart disease (SD-CHD) myocardial samples, with FN1 showing the greatest increase. In airway epithelium, FN1 was upregulated in anaphylactic sudden death (ASD) and anaphylactic sudden death (ASD) with Coronary Atherosclerosis (ASD + CAS) groups, while GP1BA was downregulated. These results indicate that FN1 serves as a key differential mouse serum biomarker, while PF4 and GP1BA aid in Sudden death from coronary heart disease (SD-CHD) diagnosis. Collectively, this multimarker, multilevel framework provides a molecular diagnostic strategy for the forensic identification of complex sudden death. - Source: PubMed
Publication date: 2026/02/25
Fan Zhi-HaoYue Zi-QiLiu Zi-KangJin Zhan-FengZhang Wei-HuaChen He - We performed a label-free quantitative plasma proteomic analysis on samples from eight astronauts who completed a 6-month mission aboard the International Space Station, using an Orbitrap Fusion Lumos mass spectrometer (MS). Blood samples were collected from each astronaut at different times, i.e., pre-flight, in-flight, and post-flight. We found that the abundance levels of 16 proteins were significantly altered (p ≤ 0.05), particularly in the in-flight samples. The functions of these 16 proteins are associated with four major pathways that pose health risks to astronauts: impairment of the immune system, reorganization of the cytoskeleton, coagulation disorders, and abnormal metabolism. Following the spaceflight, the levels of certain proteins, such as Apolipoprotein L1 (APOL1) and inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2), returned to or close to their preflight levels. While the abundance levels of some proteins involved in the actin cytoskeleton (e.g., pleckstrin or PLEK) and coagulation (e.g., platelet glycoprotein 1b alpha chain or GP1BA) decreased, others such as Brain acid soluble protein 1 (BASP1) and Insulin-like growth factor-binding protein 4 (IGFBP4) increased postflight. Although the mechanisms underlying the upregulation or downregulation of these proteins are not yet fully understood, they may play functional roles in response to spaceflight or in re-adjusting to Earth. This may impact cellular and tissue integrity as well as homeostasis, potentially leading to long-term health risks. Our findings have important implications for developing strategies to mitigate the adverse effects of spaceflight on human health. - Source: PubMed
Publication date: 2025/09/09
Rithidech KanokpornMohallem RodrigoAryal Uma KPeanlikhit TanatCrucian Brian - Neutrophil extracellular traps (NETs) have been implicated in rheumatoid arthritis (RA) pathogenesis, yet their effects on fibroblast-like synoviocytes (FLS) remain unclear. This study aims to investigate the role of NETs in RA FLS migration, proliferation, and invasion, as well as the underlying molecular mechanisms. - Source: PubMed
Publication date: 2025/11/21
Zhang YongqiangWu YingyiYang HuiLiu XuanqiPan BingDing CongzhuSun YueSun Lingyun - Considering the distinct etiological pathways and molecular characteristics of different lung cancer subtypes, it is crucial to develop subtype-specific prevention strategies and therapeutic targets. This study aimed to identify protein biomarkers and potential therapeutic targets for specific subtypes of lung cancer by integrating population-based observational studies and Mendelian randomisation (MR) analyses. The cohort study was conducted in the UK Biobank, including about 47,000 participants whose blood samples were measured for 2,923 unique proteins and who were followed for the development of lung cancer. Two-sample MR was performed leveraging publicly available data from genome-wide association studies (GWAS) and protein quantitative trait loci (pQTL). Proteins were prioritised based on consistent associations across logistic regression, MR, transcriptomic validation and sensitivity analyses. Tier 1 proteins passed all evaluations, including GP1BA (squamous cell carcinoma) and ACADSB (small cell carcinoma). Tier 2 proteins, supported by transcriptomic evidence but not sensitivity analyses, included AGRN, ITGB2, SEPTIN3 (adenocarcinoma) and DPP10 (squamous cell carcinoma). Tier 3 proteins, supported by logistic regression and MR only, included CD5L, GNPDA, ACAN, C7, DMP1, HEPH, CEACAM6, COX6B1, CPXM2 and IL12RB2. Druggability evaluation suggests that existing drugs targeting ITGB2, GP1BA, ACADSB and COX6B1 could potentially be repurposed for the treatment of specific lung cancer subtypes. - Source: PubMed
Sun WenLiu JingyangLi JiayanLi NingZhang XiaoyuLi ChangweiZhang LiHe YanWu LijuanWang XiaoJi JianguangZheng Deqiang