GAB2 pSer159 antibody Ab
- Known as:
- GAB2 pSer159 (anti-) Antibody
- Catalog number:
- 1488202
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Acris antibodies
- Gene target:
- GAB2 pSer159 antibody
Related genes to: GAB2 pSer159 antibody Ab
- Gene:
- GAB2 NIH gene
- Name:
- GRB2 associated binding protein 2
- Previous symbol:
- -
- Synonyms:
- KIAA0571
- Chromosome:
- 11q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-01-24
- Date modifiied:
- 2015-11-18
Related products to: GAB2 pSer159 antibody Ab
Related articles to: GAB2 pSer159 antibody Ab
- Not available. - Source: PubMed
Publication date: 2026/09/10
Li JuanjuanYue MeiYan YuchunZhang LeiHu TaoZhong DixiaoHu MengzeSong ZeliangShao DuanfangZhai MengnaCao JingLiu RongZheng Qinlong - Marine biofouling communities constitute a rich reservoir of microbial diversity and represent a promising source of bioactive metabolites. In this study, we investigated culturable epibiotic bacteria associated with fouling invertebrates from the Marina in northern Tunisia, with a focus on their enzymatic activities, antimicrobial potential, and antibiotic resistance profiles. A total of 52 bacterial isolates were recovered from 23 fouling invertebrate hosts and characterized using DNA barcoding and molecular identification. The epibiotic culturable bacterial community was dominated by members of the genera , , , and . Enzymatic screening revealed a high hydrolytic potential, with DNase (71.2%), lipase (65.4%), and gelatinase (59.6%) being the most prevalent activities. Antimicrobial assays showed that a substantial proportion of isolates exhibited inhibitory activity against at least one pathogenic indicator strain, whereas antibiotic susceptibility testing revealed frequent resistance, particularly to fosfomycin and cefoxitin. Together, these findings highlight the dual nature of epibiotic culturable bacteria in the Marina in northern Tunisia, acting both as a reservoir of biotechnologically valuable antimicrobial producers and as potential carriers of antibiotic resistance, underscoring their ecological relevance and public health significance in Mediterranean coastal ecosystems. - Source: PubMed
Publication date: 2026/06/29
Alouadi YosraHassen BilelJaouani ImenMraouna RadhiaBen Souissi JamilaEl Bour Monia - Chlamydia trachomatis (Ct) is an obligate intracellular bacterium that can cause severe reproductive complications, including infertility and pelvic inflammatory disease. Its pathogenicity depends on intracellular maturation, which involves differentiation between infectious elementary (EB) and replicative reticulate bodies within inclusion vacuoles. Ct is known to modulate host PI3K-AKT signaling during this process; however, the molecular basis of this regulation remains unclear. To elucidate this mechanism, we screened host factors linked to the PI3K-AKT axis using a PI3K-AKT-mTOR compound library comprising 319 inhibitors, and identified the adaptor protein Gab2 (GRB2-associated binding protein 2) as a new target molecule of Ct. Gab2 protein levels decreased during the late phase of infection, and Gab2 silencing impaired intracellular replication without affecting EB formation. These findings demonstrate that Ct infection modulates the host adaptor Gab2 during intracellular development and provide new insights into host-pathogen interactions underlying chlamydial maturation. - Source: PubMed
Publication date: 2026/07/01
Kuroiwa SoraDeguchi TaikiOkubo TorahikoNakamura ShinjiHigashi HideakiYamaguchi Hiroyuki - Immunosuppressive tumor-associated macrophages (TAMs) in the malignant ascites contribute to Poly (ADP-ribose) polymerase inhibitor (PARPi) resistance in ovarian cancer (OC). - Source: PubMed
Publication date: 2026/06/18
Liu QingbaoTang QinYe WeiChen BingZhong YanSong YonghongWang ShengZhou KechengJiang XiangxiangWang Jing - While the molecular characteristics of cutaneous melanomas (CMs) in individuals with light skin have been extensively studied, less is known about acral melanoma (AM), a non-ultraviolet radiation-induced melanoma more frequently found in individuals with darker skin. Exome and whole genome sequencing of 25 AMs from South African patients with a range of ancestral backgrounds were performed. While close to 50% in CMs, only one AM in a patient of European ancestry harbored an alteration at p.V600 in BRAF. 76% of tumors were triple wild-type. There were hotspot mutations in KIT, mutations in genes encoding components of the MAPK pathway (K57N in MAP2K1 and Y71H in HRAS), and novel candidate driver mutations in genes including PROS1, RGPD3, and SF3A3. Copy number gains included regions with TERT, CDK4, PAK1/GAB2, and DAD1 (chr14q11.2). Gain of chr17q25.1 harboring CDK3 was seen in samples with African ancestry. Eleven significantly deleted regions included chr1q43 (MAP1LC3C) and homozygous deletions of HLA-DRB1, PHF10 (chr6q27), and ATMIN (chr16q23). Mutational signatures included chromosomal instability and chromothripsis. There was a robust ancestry-related difference in tumor evolutionary dynamics where African ancestry was correlated with more genome doubling and clonality with less evolutionary branching. - Source: PubMed
Tod BiancaNam YoonheeKaya Deniz EceKotze MarithaSchneider JohannSanderson-November MichellineVisser Willem IBegani PriyaZhao JunfeiZhu AllenJanuszewski Adamde Wet JohannWedge David CRabadan RaulBowcock Anne M