GAB2 pSer159 antibody Ab
- Known as:
- GAB2 pSer159 (anti-) Antibody
- Catalog number:
- 1488202
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Acris antibodies
- Gene target:
- GAB2 pSer159 antibody
Related genes to: GAB2 pSer159 antibody Ab
- Gene:
- GAB2 NIH gene
- Name:
- GRB2 associated binding protein 2
- Previous symbol:
- -
- Synonyms:
- KIAA0571
- Chromosome:
- 11q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-01-24
- Date modifiied:
- 2015-11-18
Related products to: GAB2 pSer159 antibody Ab
Related articles to: GAB2 pSer159 antibody Ab
- Differentiating bipolar disorder (BD) from major depressive disorder (MDD) during major depressive episodes remains a significant challenge. EDIT-B is an in vitro diagnostic test based on machine learning (ML) method integrating clinical metadata with adenosine-to-inosine (A-to-I) RNA editing signatures in eight genes (, , , , , , , ) to differentiate BD from MDD. - Source: PubMed
Publication date: 2026/10/05
Weissmann DinahSalvetat NicolasCayzac ChristopherCheca-Robles FranciscoVetter DianaSantos Schneider FranciscoWalczer-Baldinazzo LaraRuggeri GiovannaFerrari MaurizioMiranda-Mendizabal AndreaChavarria VictorSoto-Angona OscarZambrano JuanZarp JeffGimenez-Palomo AnnaValenti MarcHaro Josep MariaKessing Lars VedelHenry ChantalVieta Eduard - Several activating mutations and gene fusions involving the mitogen-activated protein kinase (MAPK) pathway have appeared in the literature regarding histiocytic neoplasms. We identified a GAB2::BRAF fusion in a cutaneous lesion of a 36-year-old male who developed central diabetes insipidus and reddish-pink grouped papules on the bilateral axillary rims, inguinal region, and periocular skin. Skin biopsy obtained from an axillary lesion showed a CD68+, S100-, and CD1a- histiocytic proliferation with foamy histiocytes and multinucleated Touton giant cells, compatible with xanthogranuloma. Next-generation sequencing identified a GAB2::BRAF fusion involving Exon 2 of GAB2 and Exon 10 of BRAF. Our case further highlights this novel fusion in the MAPK signaling pathway as a possible driver of nonLangerhans cell histiocytosis (NLCH) and underscores the utility of performing molecular studies on skin biopsy specimens with NLCH to help identify potential targets for therapy. - Source: PubMed
Publication date: 2026/09/30
Xu Pauline CCushman-Vokoun Allison MD'Angelo Christopher RPradhan Dinesh - Not available. - Source: PubMed
Publication date: 2026/09/10
Li JuanjuanYue MeiYan YuchunZhang LeiHu TaoZhong DixiaoHu MengzeSong ZeliangShao DuanfangZhai MengnaCao JingLiu RongZheng Qinlong - Marine biofouling communities constitute a rich reservoir of microbial diversity and represent a promising source of bioactive metabolites. In this study, we investigated culturable epibiotic bacteria associated with fouling invertebrates from the Marina in northern Tunisia, with a focus on their enzymatic activities, antimicrobial potential, and antibiotic resistance profiles. A total of 52 bacterial isolates were recovered from 23 fouling invertebrate hosts and characterized using DNA barcoding and molecular identification. The epibiotic culturable bacterial community was dominated by members of the genera , , , and . Enzymatic screening revealed a high hydrolytic potential, with DNase (71.2%), lipase (65.4%), and gelatinase (59.6%) being the most prevalent activities. Antimicrobial assays showed that a substantial proportion of isolates exhibited inhibitory activity against at least one pathogenic indicator strain, whereas antibiotic susceptibility testing revealed frequent resistance, particularly to fosfomycin and cefoxitin. Together, these findings highlight the dual nature of epibiotic culturable bacteria in the Marina in northern Tunisia, acting both as a reservoir of biotechnologically valuable antimicrobial producers and as potential carriers of antibiotic resistance, underscoring their ecological relevance and public health significance in Mediterranean coastal ecosystems. - Source: PubMed
Publication date: 2026/06/29
Alouadi YosraHassen BilelJaouani ImenMraouna RadhiaBen Souissi JamilaEl Bour Monia - Chlamydia trachomatis (Ct) is an obligate intracellular bacterium that can cause severe reproductive complications, including infertility and pelvic inflammatory disease. Its pathogenicity depends on intracellular maturation, which involves differentiation between infectious elementary (EB) and replicative reticulate bodies within inclusion vacuoles. Ct is known to modulate host PI3K-AKT signaling during this process; however, the molecular basis of this regulation remains unclear. To elucidate this mechanism, we screened host factors linked to the PI3K-AKT axis using a PI3K-AKT-mTOR compound library comprising 319 inhibitors, and identified the adaptor protein Gab2 (GRB2-associated binding protein 2) as a new target molecule of Ct. Gab2 protein levels decreased during the late phase of infection, and Gab2 silencing impaired intracellular replication without affecting EB formation. These findings demonstrate that Ct infection modulates the host adaptor Gab2 during intracellular development and provide new insights into host-pathogen interactions underlying chlamydial maturation. - Source: PubMed
Publication date: 2026/07/01
Kuroiwa SoraDeguchi TaikiOkubo TorahikoNakamura ShinjiHigashi HideakiYamaguchi Hiroyuki