MAP2K7 pSer271 antibody Ab
- Known as:
- MAP2K7 pSer271 (anti-) Antibody
- Catalog number:
- 1488150
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Acris antibodies
- Gene target:
- MAP2K7 pSer271 antibody
Related genes to: MAP2K7 pSer271 antibody Ab
- Gene:
- MAP2K7 NIH gene
- Name:
- mitogen-activated protein kinase kinase 7
- Previous symbol:
- PRKMK7
- Synonyms:
- MKK7, Jnkk2
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-04-28
- Date modifiied:
- 2016-10-05
Related products to: MAP2K7 pSer271 antibody Ab
Related articles to: MAP2K7 pSer271 antibody Ab
- The c-Jun N-terminal kinase (JNK) pathway is a central driver of fibrosis, inflammation, and neurodegeneration. While direct JNK inhibitors have shown therapeutic promise, achieving high isoform selectivity remains a significant medicinal chemistry challenge. Furthermore, targeting the upstream 'gatekeepers' MKK4 and MKK7 offers a distinct mechanism to modulate pathway output with greater precision. Consequently, medicinal chemistry efforts have shifted upstream to the dual-specificity kinases MKK4 and MKK7. This review critically evaluates the structural biology and pharmacological evolution of small-molecule inhibitors targeting these nodes. We contrast the distinct therapeutic landscapes of the two kinases: while MKK4 inhibition has emerged as a breakthrough strategy for unlocking liver regeneration (exemplified by the first-in-class clinical candidate HRX215), MKK7 inhibition is primarily pursued for its anti-fibrotic and anti-inflammatory potential. Special attention is given to structure-based design strategies, including the exploitation of the unique hinge-region cysteine (Cys218) for MKK7-specific covalent targeting and the optimization of scaffold selectivity against off-targets like BRAF. Finally, we discuss emerging modalities, such as PROTACs and dual inhibitors, outlining a roadmap for the next generation of precision therapeutics targeting the MKK-JNK axis. - Source: PubMed
Publication date: 2026/02/15
Zhao MinLi BaojianGao YingLiang YanShao NanqiShi XinboLi Jie - The development of anti-inflammatory drugs is a research focus. Acute lung injury (ALI) is a life-threatening inflammatory syndrome that currently lacks effective pharmacotherapies. Here, we report a potential therapy for ALI by targeting c-Jun N-terminal kinase 2 (JNK2), a key regulator of MAPK pathway-driven inflammatory responses. Through structure-based virtual screening and systematic structural optimization, we identified compound , which potently inhibited the secretion of IL-6 in THP-1 (IC = 0.14 μM) and TNF-α in J774A cells (IC = 0.55 μM). Mechanistic studies revealed that functioned through the dual inhibition of JNK2 kinase activity and the protein-protein interaction between MKK7 and JNK2, thus inhibiting the phosphorylation of c-Jun and thereby attenuating the LPS-induced inflammatory cytokine overexpression. Furthermore, showed potent therapeutic effects on both LPS- and CLP-induced ALI in mice and exhibited favorable pharmacokinetics and safety profiles, establishing as a promising candidate for ALI treatment. - Source: PubMed
Publication date: 2026/02/23
Chen QiDong KeZhan YapingHuang NanChen PanJiang MiaoZhu LuxiaoZhang KaixinLv YuehuaZou YuChen ZhichaoGuo MiSun ChenhuiCho Young-ChangZeng RuifengWu DiLiang GuangTang Qidong - This study investigated whether alterations in the expression of genes integral to the c-Jun N-terminal kinase (JNK) signaling pathway play a role in the pathogenesis of colorectal cancer (CRC). It analyzed the expression of genes encoding two JNK isoforms (MAPK8 and MAPK9) and the JNK-activating kinases (MAP2K4 and MAP2K7). Gene expression patterns in CRC tissue were compared with existing data in public online databases to provide an integrated understanding of their potential role in tumorigenesis. The material consisted of 55 cancer tissue fragments collected intraoperatively from patients with histopathologically confirmed CRC. Total RNA isolated from these tissues was used to determine the relative expression of the selected genes using quantitative PCR. Additionally, data from publicly accessible bioinformatics databases were utilized. gene expression was significantly elevated in tumor specimens with higher histological grades. Conversely, gene expression tended to be higher in tumor tissues with lower histological grades. Moreover, elevated MAPK8 gene expression was linked to an increased incidence of regional lymph node metastasis. Furthermore, bioinformatics analysis confirmed that and appear to promote tumor aggressiveness and metastasis, whereas and may have a protective or regulatory role in early stages of the disease. - Source: PubMed
Publication date: 2025/12/22
Wosiak AgnieszkaWodziński DamianŚwiechowski RafałPietrzak JacekMik MichałBalcerczak Ewa - Psoriasis is a chronic autoimmune disorder characterized by immune dysregulation and excessive keratinocyte proliferation. The mitogen-activated protein kinase (MAPK) signaling pathway plays a key role in driving inflammation in psoriatic skin. - Source: PubMed
Publication date: 2026/01/07
Plata-Babula AleksandraWójcik MichałGłowaczewska AmeliaZmarzły NikolaChalcarz MichałKaminiow KonradMitka-Krysiak ElżbietaKuraszewska BernadetaWieczorek WeronikaGrabarek Beniamin Oskar - Early age of onset is a major predictor of poor disease course in Bipolar Disorder (BD) and Schizophrenia (SCZ), often associated with greater symptom severity, cognitive decline, and worse outcomes. However, the biological mechanisms that shape age- and sex-specific vulnerability remain unclear, limiting progress toward early identification and intervention. To address this gap, we conducted an integrative transcriptomic study of 369 postmortem dorsolateral prefrontal cortex samples from the CommonMind Consortium. Differential gene expression, Weighted Gene Co-Expression Network Analysis, and gene set enrichment analysis were applied to identify pathways associated with age of onset, complemented by sex-stratified models and cellular deconvolution. To assess predictive signals, we applied a rigorous two-stage machine-learning framework using nested cross-validation, with Lasso feature selection followed by L2-regularized logistic classification. Performance was evaluated solely on held-out test folds. Genes and modules linked to earlier onset showed consistent enrichment for calcium signaling, with downregulation of and multiple adenylate-cyclase-related transcripts, while female-specific analyses revealed selective dysregulation of cyclase-associated pathways. Network analysis identified a calcium-enriched module associated with onset and sex, and diagnosis-specific modeling highlighted in early-onset BD. The predictive model achieved an AUC of 0.63, and the top 50 machine-learning features were significantly enriched in calcium signaling pathway. These findings converge on calcium-cAMP signaling networks as key drivers of early psychiatric vulnerability and suggest biomarkers for precision-targeted interventions. - Source: PubMed
Publication date: 2025/12/16
Afjeh Sara SadatDey SohomKiss DanielSanches MarcosDos Santos FernandaPouget Jennie GAkbarian NikiTripathy ShreejoyGonçalves Vanessa FKennedy James L