PRKACA / PRKACB pThr197 antibody Ab
- Known as:
- PRKACA / PRKACB pThr197 (anti-) Antibody
- Catalog number:
- 1488027
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Acris antibodies
- Gene target:
- PRKACA / PRKACB pThr197 antibody
Related genes to: PRKACA / PRKACB pThr197 antibody Ab
- Gene:
- PRKACA NIH gene
- Name:
- protein kinase cAMP-activated catalytic subunit alpha
- Previous symbol:
- -
- Synonyms:
- PKACa
- Chromosome:
- 19p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-01-27
- Gene:
- PRKACB NIH gene
- Name:
- protein kinase cAMP-activated catalytic subunit beta
- Previous symbol:
- -
- Synonyms:
- PKACb
- Chromosome:
- 1p31.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
Related products to: PRKACA / PRKACB pThr197 antibody Ab
Related articles to: PRKACA / PRKACB pThr197 antibody Ab
- Carney complex (CNC) is an autosomal dominant multiple neoplasm syndrome, characterized by the presence of endocrine and non-endocrine tumors; it includes myxomas, lentigines and primary pigmented nodular adrenocortical disease, among other signs/symptoms. In CNC type 1, inactivating mutations of the PRKAR1A gene were identified as the main cause of the disease, although since 2015 variants in other genes, including PRKACA and PRKACB, have also been linked to this pathology. PKA is an enzyme involved in the G protein-coupled intracellular pathways and serves as a mediator of c-AMP actions that promote cell metabolism, proliferation and apoptosis. The penetrance of CNC due to pathogenic variants in the PRKAR1A gene is close to 100%. We present the case of a 33-year-old female patient with cutaneous and mucosal lentiginosis, blue nevus, malignant melanocytic psammomatous schwannoma, cutaneous myxoma and a novel variant in the PRKAR1A gene. - Source: PubMed
Publication date: 2026/04/15
Vázquez Ares María JoséRolón CamilaMercado Graciela - Late-life depression (LLD) with high prevalence accelerates cognitive impairment and becomes a risk factor for dementia, yet the pathogenesis of LLD is still largely unclear. Delineating the neuromolecular mechanism of LLD is of great significance to its etiology, early diagnosis, and precision treatment. - Source: PubMed
Publication date: 2026/04/16
Chen MeilingZhang HongjiangYu XiaohuiZhang JieZhong JingmeiChen KexuanZi RongWu ZheWang ZhiyuanWu KunhuaWang JiaojianShao HengZhao YingZhu Baosheng - Intraductal neoplasms of the pancreas encompass a spectrum of epithelial proliferations within the pancreatic ductal system and are broadly classified into flat-type and mass-forming lesions. Flat-type neoplasms, such as pancreatic intraepithelial neoplasia (PanIN), consist of microscopic epithelial changes, whereas mass-forming intraductal neoplasms-including intraductal papillary mucinous neoplasm (IPMN), intraductal oncocytic papillary neoplasm (IOPN), and intraductal tubulopapillary neoplasm (ITPN)-produce clinically or radiologically detectable ductal dilatation or cystic masses. Both categories represent important precursors to invasive pancreatic carcinoma, and accurate classification, grading, and distinction between pseudo-invasion and true invasion remain critical for patient management and prognostication. Gastric-type IPMNs, most often arising in branch ducts, tend to exhibit indolent behavior. Intestinal-type IPMNs, typically involving the main duct and characterized by MUC2 and CDX2 expression, carry a higher risk of progression to invasive colloid carcinoma, which generally has a more favorable outcome. Pancreatobiliary-type IPMNs frequently involve the main duct, express MUC1 and MUC5AC, and more commonly progress to tubular invasive carcinoma resembling pancreatic ductal adenocarcinoma. IOPN and ITPN constitute distinct mass-forming intraductal neoplasms. IOPN typically presents as a large cystic lesion with complex papillary architecture and demonstrates recurrent PRKACA or PRKACB fusions. ITPN is defined by its predominantly tubular growth pattern, mucin-poor phenotype, and absence of MUC5AC expression. Both entities are associated with favorable outcomes following complete resection. Recognition of these intraductal neoplasms is essential, as they must be distinguished from other cystic pancreatic lesions such as mucinous cystic neoplasm (MCN), which is defined by its characteristic ovarian-type stroma. - Source: PubMed
Publication date: 2026/03/03
Bakkaloglu Irem GuvendirAdsay VolkanBasturk Olca - Ubiquitylation is a vital post-translational modification involved in various biological processes, yet its role in the human hypothalamus remains largely unexplored. This study aims to profile the ubiquitinome of the human hypothalamus, uncovering the ubiquitylation landscape and its potential implications in hypothalamic function. - Source: PubMed
Publication date: 2025/11/09
Zhang Zhi-YiDing TaoKong JieWang Qiao-ChuZhang Xu-TongShi Chun-MeiYang Jun-TaoLiu Jiang-Feng - We reviewed recent advancements in the characterization of intraductal oncocytic papillary neoplasm (IOPN) of the pancreas, with a specific focus on developments in immunohistochemical markers, molecular pathology, and pathogenic mechanisms over the past ten years (2015-2024). Through comprehensive analysis of current literature, we aimed to elucidate the evolving understanding of IOPN's biological behavior and diagnostic features, while identifying potential areas for future research in this distinctive pancreatic neoplasm. - Source: PubMed
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