IL1B & A2M Protein Protein Interaction Antibody Pair
- Known as:
- IL1B & A2M Protein Protein Interaction Antibody Pair
- Catalog number:
- DI0035
- Product Quantity:
- 1 Set
- Category:
- -
- Supplier:
- Abno
- Gene target:
- IL1B & A2M Protein Interaction Antibody Pair
Related genes to: IL1B & A2M Protein Protein Interaction Antibody Pair
- Gene:
- CASP1 NIH gene
- Name:
- caspase 1
- Previous symbol:
- IL1BC
- Synonyms:
- ICE
- Chromosome:
- 11q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-05-07
- Date modifiied:
- 2016-10-05
- Gene:
- IL1B NIH gene
- Name:
- interleukin 1 beta
- Previous symbol:
- -
- Synonyms:
- IL1F2, IL-1B, IL1-BETA
- Chromosome:
- 2q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 1989-03-31
- Date modifiied:
- 2016-10-05
Related products to: IL1B & A2M Protein Protein Interaction Antibody Pair
Related articles to: IL1B & A2M Protein Protein Interaction Antibody Pair
- Paracoccidioidomycosis (PCM) is an endemic systemic mycosis in Latin America with marked clinical heterogeneity, suggesting a role for host immunogenetic factors. The NLRP3 inflammasome and IL-1β signaling are important in antifungal immunity, but human genetic evidence remains limited. We evaluated whether single-nucleotide variants (SNVs) in inflammasome-related genes (NLRP1, NLRP3, CARD8, CASP1, and IL1B) are associated with PCM susceptibility, clinical form, and disease severity, including gene-gene interactions. - Source: PubMed
Publication date: 2026/09/09
da Silva Coelho SandersonAmorim Bárbara CasellaRamos Jeferson Vidartda Costa Marques Ana Paulade Oliveira Sandra Maria do Valle LeonePereira-Latini Ana Carlade Souza Vânia Nieto Britode Rezende Romera Grazielli Rochade Melo Dayane Alvesde Albuquerque Viviane LimaPontillo AlessandraSoares Pereira Beatriz Aparecidade Souza Cavalcante RicardoMendes Rinaldo PoncioPaniago Anamaria Mello MirandaFava Wellington SantosVenturini James - Pararamosis, or pararama-associated phalangeal periarthritis, is a neglected tropical disease affecting rubber tappers in the Amazon, caused by contact with the urticating bristles of the caterpillar. This condition leads to chronic synovitis and progressive cartilage degradation, key features shared with other osteoarticular conditions such as osteoarthritis. - Source: PubMed
Publication date: 2026/08/25
Pohl Paula CZapotoski Luiza N KSardinha Luiz RVillas-Boas Isadora MPidde GiselleTambourgi Denise V - Neuroinflammation plays an important role in the pathobiology of Progressive Supranuclear Palsy Syndrome (PSP-S). However, it is not adequately known whether peripheral inflammation correlates to neuroinflammation in PSP-S. This study aimed to examine a link between peripheral and brain inflammation in PSP-S by integrating blood and cerebrospinal fluid (CSF) inflammatory profile and Positron Emission Tomography (PET)-Magnetic Resonance Imaging (MRI) (PET-MRI). - Source: PubMed
Publication date: 2026/07/23
Dey SaikatKumar AishwaryaKumar PardeepKavya Paranthaman VMondal SandipanHolla Vikram VKamble NitishMahale RohanPal Pramod KYadav RaviDebnath Monojit - Fibroblasts are linked to stress responses in a broad number of diseases. Here, we used immortalized mouse embryonic fibroblasts (iMEFs) to elucidate their signaling behavior in response to proinflammatory lipopolysaccharides (LPS) and angiotensin II (Ang-II). To test for the role of the mitochondrial electron transport chain (ETC), iMEFs were cultured in glucose- and galactose-containing media promoting glycolysis and mitochondrial oxidative phosphorylation, respectively. In addition, we used alternative oxidase (AOX), a ubiquinol oxidoreductase that serves as a naturally evolved rescue mechanism in case of ETC disruption. We found that within 24 h of treatment, LPS upregulated a number of proinflammatory genes, namely Tlr4, Il6, Tgfb1, Nlrp3, Casp1, and Il1b; largely, the effect was more pronounced in galactose-containing media and attenuated by AOX. The increase in transcripts resulted partly in elevated cytokine secretion. Twenty-four hours of Ang-II treatment also induced these genes, albeit to a lesser degree and less sensitive to AOX. Cellular oxygen consumption rates (OCRs) were higher in galactose media but remained unaffected by either stimulus. Our results suggest that fibroblasts undergo a similar proinflammatory phenotypic shift in response to different stressors. This response is shaped by ETC activity, which, surprisingly, is not reflected in altered OCRs. - Source: PubMed
Publication date: 2026/08/05
Mühlon Marie MSchenkl ChristinaHarder LukasGiordano LucaVoll Julian MFranke ChristianDudziak DianaDoenst TorstenClaus Ralf ASzibor Marten - Melanoma is an aggressive form of skin cancer characterized by high metastatic potential and increasing incidence and mortality worldwide. Although significant advances have been achieved with immune checkpoint inhibitors and targeted therapies, effective preventive and long-term therapeutic strategies remain limited. Bacillus Calmette-Guérin (BCG), widely used in bladder cancer immunotherapy, exhibits potent immunostimulatory properties and has emerged as a promising platform for recombinant cancer vaccines. Among the candidate antigens, Antigen 85A (Ag85A), derived from Mycobacterium bovis, is notable for its strong immunogenicity and ability to induce robust Th1-mediated cellular immune responses. In this study, recombinant BCG strains overexpressing efficacy was evaluated in melanoma models in vitro and in vivo. Gene expression analysis by RT-qPCR revealed that rBCG-Ag85A induced systemic immune activation, characterized by increased Il1B and Trl4 expression in splenocytes. In tumor tissues, rBCG-Ag85A significantly upregulated genes associated with apoptosis (Bax, Bcl2), oxidative stress (Sod1, Cat), inflammatory and immune signaling pathways (Tlr4, Nfkb, Il12, Il1b, Casp1), and modulation of pathways involved in cellular metabolism (Mtor) indicating enhanced modulation of the tumor microenvironment. Functionally, these molecular and immunological effects were associated with reduced tumor progression, slower tumor growth, and improved survival in B16F10 melanoma-bearing mice. Collectively, these findings demonstrate that rBCG-Ag85A promotes multifaceted antitumor activity through the modulation of apoptosis, inflammation and oxidative stress-related gene expression, highlighting its potential as a promising prophylactic vaccine strategy to prevent cutaneous malignant melanoma and supporting future studies aimed at elucidating the immune cell populations involved and optimizing combinatorial therapeutic approaches. - Source: PubMed
Publication date: 2026/08/05
Lanius Suzana LemkePacheco Bruna SilveiraSousa Fernanda Severo SabedraNeto Amilton Clair Pinto SeixasScholl Nicole RamosCardozo Stella Julli FariasEhlert Maria EduardaFerreira Valentina GessingerCollares Tiago VeirasBorsuk SibeleDellagostin OdirBohn Thais Larre OliveiraSeixas Fabiana Kömmling