CREB1 polyclonal antibody
- Known as:
- CREB1 pab (anti-)
- Catalog number:
- PAB9994
- Product Quantity:
- 100 uL
- Category:
- -
- Supplier:
- Abno
- Gene target:
- CREB1 polyclonal antibody
Related genes to: CREB1 polyclonal antibody
- Gene:
- CREB1 NIH gene
- Name:
- cAMP responsive element binding protein 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 1990-02-05
- Date modifiied:
- 2016-10-05
Related products to: CREB1 polyclonal antibody
Related articles to: CREB1 polyclonal antibody
- Triple-negative breast cancer (TNBC) harbors an immunosuppressive tumor microenvironment dominated by tumor-associated macrophages (TAMs). P2RY6, a UDP-sensitive purinergic receptor, is implicated in immune modulation, but its functional role in TNBC TAMs remains elusive. - Source: PubMed
Publication date: 2026/06/06
Wang XinMa MingyueZhang MingyuLu HanLiu YingZhou YangHan Bing - Cigarette smoke (CS) exposure disrupts bronchial epithelial redox homeostasis, serving as a primary etiology of chronic bronchitis; however, the specific mechanisms linking ion transport dysregulation to CS-induced cytotoxicity remain poorly understood. This study identifies a critical protective role for the voltage-gated chloride channel ClC-3, a Cl/H exchanger, in maintaining airway epithelial integrity against oxidative insult. We report significant downregulation of ClC-3 in the bronchial epithelium of chronic bronchitis patients and CS-exposed mice. Using transgenic overexpression and conditional knockout mouse models, we demonstrate that ClC-3 deficiency exacerbates, while its overexpression mitigates, CS-induced airway inflammation, systemic oxidative stress (SOD/MDA), and lung injury. Mechanistically, we show that CS exposure suppresses AKT phosphorylation, leading to the inactivation of the transcription factor CREB1. We validate that CREB1 acts as a direct transcriptional activator of CLCN3 by binding to its promoter; thus, the CS-mediated inhibition of the AKT/CREB1 axis results in transcriptional silencing of ClC-3. At the cellular level, loss of ClC-3 disrupts lysosomal acidification, resulting in a blockade of autophagic flux. This impairment prevents the effective clearance of oxidative damage, thereby promoting epithelial cell death and amplifying inflammatory responses. Collectively, these findings delineate a novel "CS-AKT/CREB1-ClC-3-Lysosome" axis, suggesting that restoring ClC-3-mediated lysosomal function represents a promising therapeutic strategy to restore redox balance in chronic bronchitis. - Source: PubMed
Publication date: 2026/06/01
Zhang XiaotingYe DongXiong ZixianQiu XiaofengYu JingweiYu JieLi MenggeHuang YufangYin HuaGuo XinminXu BinMao Jianwen - Atrophic macular degeneration comprises dry age-related macular degeneration (AMD) and autosomal recessive Stargardt disease (STGD1). These disorders lead to irreversible blindness and still lack effective therapies. The rise of all-trans-retinal (atRAL) brought on by visual cycle disruption closely links to retinal atrophy in both conditions, yet the key downstream targets remain obscure. Exendin-4 (EX-4) is a natural glucagon-like peptide-1 receptor (GLP-1R) agonist. Recent clinical retrospective studies indicate that GLP-1R agonists such as exenatide (synthetic EX-4) can markedly lower the 5-year risk of developing dry AMD. Here, we sought to clarify the protective effect of natural EX-4 against retinal degeneration in atrophic macular degeneration linked to impaired clearance of atRAL. - Source: PubMed
Publication date: 2026/05/30
He BeitingChen YulingCai PeixinXi RuitongShen XiaoqingGuo ShutingChen JingmengLi ShiyingWu Yalin - Sleep is a vital process for restoring brain function and is recognized as a fundamental aspect of both physical and mental health. This study aims to assess the molecular mechanisms of insomnia disorder and identify the key dysregulated genes associated with it. - Source: PubMed
Publication date: 2025/09/01
Mansouri VahidArjmand BabakAsri NastaranRazzaghi ZahraRezaei-Tavirani MostafaRazi FaridehBandarian FatemehRobati Reza MRezaei Mitra - To determine whether sleep architecture is associated with heterogeneity in serum biomarkers of neuronal injury, astroglial stress, tau-related pathology, and neuroplasticity in adults with obstructive sleep apnea (OSA). - Source: PubMed
Publication date: 2026/05/22
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